Table 2. No. of Lung Cancer Patients and Lung Cancer AAIR Per 100,000 Person-Years Among Adults Age 40 to 79 Years, Percentage of Patients With Adenocarcinoma Histology, and Median Age at Diagnosis by Smoking Status in the Cohorts

Cohort Smoking Status
Never Former Current
NHS, female
    Incident lung cancer patients, No. 168 711 938
    Age-truncated AAIR 15.2 76.9 293.3
        95% CI 9.1 to 24.5 63.7 to 93.2 266.7 to 322.9
    Adenocarcinoma, % 70 50 42
        95% CI 62 to 78 46 to 54 39 to 46
    Median age at diagnosis, years 64 68 64
HPFS, male
    Incident lung cancer patients, No. 43 312 173
    Age-truncated AAIR 11.2 67.6 304.5
        95% CI 6.5 to 19.0 56.4 to 82.5 277.4 to 334.7
    Adenocarcinoma, % 54 51 30
        95% CI 37 to 71 45 to 57 23 to 39
    Median age at diagnosis, years 67 71 68
CTS, female
    Incident lung cancer patients, No. 91 179 123
    Age-truncated AAIR 20.8 65.6 264.4
        95% CI 13.5 to 31.2 54.8 to 79.4 240.0 to 291.7
    Adenocarcinoma, % 64 54 34
        95% CI 53 to 74 46 to 61 26 to 43
    Median age at diagnosis, years 67 70 67
MEC, male*
    Incident lung cancer patients, No. 47 520 511
    Age-truncated AAIR 13.7 80.0 314.6
        95% CI 9.0 to 21.5 67.1 to 96.1 284.6 to 347.7
    Adenocarcinoma, % 53 42 31
        95% CI 38 to 68 37 to 46 27 to 36
    Median age at diagnosis, years 72 72 69
MEC, female*
    Incident lung cancer patients, No. 142 270 393
    Age-truncated AAIR 20.7 65.2 233.7
        95% CI 13.5 to 31.1 53.5 to 80.2 208.5 to 261.8
    Adenocarcinoma, % 58 46 32
        95% CI 49 to 66 40 to 52 28 to 37
    Median age at diagnosis, years 72 70 67
U/OLCR, male
    Incident lung cancer patients, No. 10 124 139
    Age-truncated AAIR 4.8 59.8 173.7
        95% CI 2.2 to 10.6 48.1 to 74.5 153.4 to 197.0
    Adenocarcinoma, % 67 36 34
        95% CI 30 to 93 28 to 45 26 to 42
    Median age at diagnosis, years 64 71 64
U/OLCR, female
    Incident lung cancer patients, No. 37 68 145
    Age-truncated AAIR 14.4 51.4 149.4
        95% CI 8.2 to 23.6 39.9 to 66.0 129.4 to 172.4
    Adenocarcinoma, % 64 46 38
        95% CI 46 to 79 33 to 58 30 to 46
    Median age at diagnosis, years 67 66 63
NHEFS, male{dagger}
    Incident lung cancer patients, No. 4 45 111
    Age-truncated AAIR 12.7 141.4 362.7
        95% CI 10.2 to 18.2 124.9 to 161.0 334.8 to 393.6
    Median age at diagnosis, years 78 72 69
NHEFS, female{dagger}
    Incident lung cancer patients, No. 15 10 50
    Age-truncated AAIR 19.3 69.1 168.8
        95% CI 14.2 to 27.5 57.2 to 84.1 146.1 to 194.5
    Median age at diagnosis, years 71 67 62

Abbreviations: AAIR, age-adjusted incidence rate for invasive lung cancer (per 100,000 person-years) standardized to US 2000 standard million population between age 40 and 79 years; NHS, Nurses’ Health Study; HPFS, Health Professionals Follow-Up Study; CTS, California Teachers Study; MEC, Multiethnic Cohort Study; U/OLCR, Swedish Uppsala/Örebro Lung Cancer Register; NHEFS, First National Health and Nutrition Examination Survey Epidemiologic Follow-Up Study.

* MEC participants and lung cancer patients were restricted to age 45 to 79 years; the incidence rate of lung cancer in those 40 to 44 years old was assumed to be half that among those 45 to 49 years old for calculation of AAIRs.

{dagger} The NHEFS lacked information on tumor histology.