Journal of Clinical Oncology, Vol 10, 1014-1024, Copyright © 1992 by American Society of Clinical Oncology
Inflammatory breast cancer: a review
IA Jaiyesimi, AU Buzdar and G Hortobagyi
Department of Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston 77030.
PURPOSE: The natural history of inflammatory breast cancer and the recent
advances in its management were reviewed. DESIGN: The English medical
literature from 1924 to 1990 was reviewed using the Cancerline and Medline
retrieval systems, and through a manual review of bibliographies of
identified articles. RESULTS: The majority of patients with inflammatory
breast cancer treated only with local therapies died 18 to 24 months after
diagnosis. A combined modality approach with chemotherapy, surgery, and
radiation therapy has improved disease-free and overall survival rates for
inflammatory breast cancer. Approximately 35% to 55% of patients treated
with combined modality regimens remain disease-free and alive at 5 years.
CONCLUSION: Induction combination chemotherapy administered with radiation
therapy, mastectomy, both, or with additional chemotherapy favorably alters
the natural history of inflammatory breast cancer. New drug combinations
and high-dose chemotherapy with autologous bone marrow support are being
evaluated to improve further patient survival.

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