Journal of Clinical Oncology, Vol 11, 2043-2049, Copyright © 1993 by American Society of Clinical Oncology
Effect of dietary counseling on food intake, body weight, response rate, survival, and quality of life in cancer patients undergoing chemotherapy: a prospective, randomized study
L Ovesen, L Allingstrup, J Hannibal, EL Mortensen and OP Hansen
Department of Medicine P, Bispebjerg University Hospital, Copenhagen, Denmark.
PURPOSE: This study examined the effect of frequent nutritional counseling
on oral intake, body weight, response rate, survival, and quality of life
in patients with cancer of the lung (small-cell), ovary, or breast
undergoing cyclic chemotherapy. PATIENTS AND METHODS: Of 105 assessable
patients, 57 were randomized to receive nutritional counseling, and 48 to
receive no nutritional counseling and consumption of an ad lib oral intake.
The intervention group was counseled to achieve a daily energy and protein
intake according to recommended dietary allowances. Counseling was
standardized and performed by a trained dietitian, and took place twice
monthly during a 5-month period from start of chemotherapy. RESULTS:
Dietary counseling increased daily energy intake by approximately 1 MJ and
protein intake by 10 g over the entire study period. There was no change in
the control group. Counseling led to an insignificant increase in body
weight, but triceps skinfold measurement increased significantly after 5
months. Response rate and overall survival did not differ between the
groups. Quality of life measured by the Quality-of-Life index (QL-index)
increased significantly in both groups, but did not differ between groups.
CONCLUSION: No clinical benefit could be demonstrated despite long-term and
continuous improved food intake in cancer patients with solid tumors
undergoing aggressive chemotherapy.
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