Journal of Clinical Oncology, Vol 13, 2688-2699, Copyright © 1995 by American Society of Clinical Oncology

ARTICLES

Paclitaxel by 3-hour infusion in combination with bolus doxorubicin in women with untreated metastatic breast cancer: high antitumor efficacy and cardiac effects in a dose-finding and sequence-finding study

L Gianni, E Munzone, G Capri, F Fulfaro, E Tarenzi, F Villani, C Spreafico, A Laffranchi, A Caraceni and C Martini
Division of Medical Oncology, Istituto Nazionale Tumori, Milano, Italy.

PURPOSE: To define the maximum-tolerated dose (MTD) and better tolerated sequence of paclitaxel by 3-hour infusion plus bolus doxorubicin (DOX) and to evaluate antitumor efficacy. PATIENTS AND METHODS: Thirty-five women with metastatic breast cancer (dominant visceral metastases in 56%, and involvement of > or = three sites in 67%) who never received chemotherapy of any type were studied. Paclitaxel every 3 weeks (125 mg/m2 starting dose) was increased by 25- mg/m2 steps in subsequent cohorts of patients. DOX (60 mg/m2 fixed dose) was administered 15 minutes before the start of or after the end of paclitaxel for a maximum of eight cycles. Subsequently, patients in continuous response could receive single-agent paclitaxel (175 to 200 mg/m2 every 3 weeks). The drug sequence was alternated in consecutive patients and in the first two cycles. RESULTS: Severe neutropenia that lasted greater than 7 days (n = 4), febrile neutropenia (n = 7) and grade III oral mucositis (n = 6) defined the MTD of paclitaxel at 200 mg/m2 in 34 assessable patients. Grade II peripheral neuropathy occurred in 33% of patients. Six women (18%) developed clinically reversible congestive heart failure (CHF) after a median of 480 mg/m2 total DOX. Drug sequence had no effect on toxicities. High efficacy on all metastatic sites in 32 assessable patients accounted for a 41% complete response (CR) rate (95% confidence interval [CI], 24% to 59%) and 94% overall-response rate (95% CI, 79% to 99%). After a median follow-up of 12 months (range 3 to 18), the median response duration is 8 months (range, 2+ to 18+) for complete responders and 11 months (range 1+ to 15+) for partial responders. CONCLUSION: The rate of CR and incidence of CHF may be an expression of therapeutic and toxic enhancement due to the schedule used in this trial. Until clarification of this possibility, this promising combination should be used in investigational trials.
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				M. Esposito, M. Venturini, M.O. Vannozzi, G. Tolino, G. Lunardi, O. Garrone, C. Angiolini, M. Viale, M. Bergaglio, L. Del Mastro, et al. Comparative Effects of Paclitaxel and Docetaxel on the Metabolism and Pharmacokinetics of Epirubicin in Breast Cancer Patients J. Clin. Oncol., April 1, 1999; 17(4): 1132 - 1132. [Abstract] [Full Text] [PDF]

				J. Feenstra, D. E. Grobbee, W. J. Remme, and B. H. C. Stricker Drug-induced heart failure J. Am. Coll. Cardiol., April 1, 1999; 33(5): 1152 - 1162. [Abstract] [Full Text] [PDF]

				C. Kouroussis, N. Androulakis, S. Kakolyris, J. Souglakos, T. Kotsakis, D. Mavroudis, K. Katsogridakis, N. Vardakis, D. Hatzidaki, G. Samonis, et al. Dose-Escalation Study of Docetaxel in Combination With Mitoxantrone as First-Line Treatment in Patients With Metastatic Breast Cancer J. Clin. Oncol., March 1, 1999; 17(3): 862 - 862. [Abstract] [Full Text] [PDF]

				J. A. Sparano, J. Speyer, W. J. Gradishar, L. Liebes, R. Sridhara, S. Mendoza, D. Fry, and M. J. Egorin Phase I Trial of Escalating Doses of Paclitaxel Plus Doxorubicin and Dexrazoxane in Patients With Advanced Breast Cancer J. Clin. Oncol., March 1, 1999; 17(3): 880 - 880. [Abstract] [Full Text] [PDF]

				S. E. Lipshultz, M. A. Grenier, S. D. Colan, A. D. Ginsburg, S. M. Swain, F. M. Muggia, J. L. Speyer, P. K. Singal, C. L.M. Olweny, and T. Li Doxorubicin-Induced Cardiomyopathy N. Engl. J. Med., February 25, 1999; 340(8): 653 - 655. [Full Text]

				S. G. Diab, S. D. Baker, A. Joshi, H. A. Burris, P. W. Cobb, M. A. Villalona-Calero, S. G. Eckhardt, G. R. Weiss, G. I. Rodriguez, R. Drengler, et al. A Phase I and Pharmacokinetic Study of Losoxantrone and Paclitaxel in Patients with Advanced Solid Tumors Clin. Cancer Res., February 1, 1999; 5(2): 299 - 308. [Abstract] [Full Text] [PDF]

				C. L. Vogel and J.-M. Nabholtz Monotherapy of Metastatic Breast Cancer: A Review of Newer Agents Oncologist, February 1, 1999; 4(1): 17 - 33. [Abstract] [Full Text]

				A. du Bois, H. J. Luck, T. Bauknecht, W. Meier, B. Richter, W. Kuhn, J. Quaas, and J. Pfisterer First-Line Chemotherapy With Epirubicin, Paclitaxel, and Carboplatin for Advanced Ovarian Cancer: A Phase I/II Study of the Arbeitsgemeinschaft Gynakologische Onkologie Ovarian Cancer Study Group J. Clin. Oncol., January 1, 1999; 17(1): 46 - 46. [Abstract] [Full Text] [PDF]

				L. R. Acuna, M. Langhi, J. Perez, J. R. Acuna, M. Machiavelli, J. Lacava, C. Vallejo, A. Romero, H. Fasce, E. Ortiz, et al. Vinorelbine and Paclitaxel as First-Line Chemotherapy in Metastatic Breast Cancer J. Clin. Oncol., January 1, 1999; 17(1): 74 - 74. [Abstract] [Full Text] [PDF]

				E. A. Perez Paclitaxel in Breast Cancer Oncologist, December 1, 1998; 3(6): 373 - 389. [Abstract] [Full Text]

				L. K Webster, D. M Woodcock, D. Rischin, and M. J Millward Review : Cremophor: Pharmacological activity of an "inert" solubiliser Journal of Oncology Pharmacy Practice, December 1, 1997; 3(4): 186 - 192. [Abstract] [PDF]

				C. A. Hudis and L. Norton Adjuvant Drug Treatment for Resectable Breast Cancer Oncologist, December 1, 1997; 2(6): 351 - 358. [Abstract] [Full Text] [PDF]

				M. Zambetti, A. Giacobone, M. Terenziani, P. Zucchinelli, R. Demicheli, S. Biasi, P. Piotti, C. Bartoli, P. Valagussa, and G. Bonadonna Sequential Adriamycin and CMF in Metastatic Breast Cancer Oncologist, August 1, 1997; 2(4): 223 - 227. [Abstract] [Full Text] [PDF]