Advertisement
Journal of Clinical Oncology  
Search for:
Limit by:
  Browse by Subject or Issue
Home Search or Browse JCO Subscriptions PDA Services My JCO Customer Service

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Save to my personal folders
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Talcott, J. A.
Right arrow Articles by Kantoff, P. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Talcott, J. A.
Right arrow Articles by Kantoff, P. W.

Journal of Clinical Oncology, Vol 16, 275-283, Copyright © 1998 by American Society of Clinical Oncology

ARTICLES

Patient-reported symptoms after primary therapy for early prostate cancer: results of a prospective cohort study

JA Talcott, P Rieker, JA Clark, KJ Propert, JC Weeks, CJ Beard, KI Wishnow, I Kaplan, KR Loughlin, JP Richie and PW Kantoff
Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, MA, USA. james_talcott@dfci.harvard.edu

PURPOSE: To assess complications of therapy for early (nonmetastatic) prostate cancer. PATIENTS AND METHODS: A prospective study of a cohort of 279 men who sought treatment advice and completed required pretreatment forms. The measures were self-reported patient symptoms and other measures of quality of life before therapy and at 3 and 12 months afterward. RESULTS: Bowel and bladder symptoms were uncommon pretreatment. Patients frequently reported irritative bowel and bladder symptoms at 3 months after radiotherapy, although these subsided somewhat at 12 months. Substantial ("a lot") urinary incontinence and wearing of absorptive pads were reported by 11% and 35% at 12 months after surgery and varied little by age. Incontinence occurred after radiotherapy infrequently, and only in men more than 65 years old. Inadequate erections, present in one third of men pretreatment, were nearly universal at 3 months after surgery, although some improvement, primarily in men under 65 years of age, was evident at 12 months. Sexual dysfunction after radiotherapy increased less but continually through 12 months, suggesting that observed treatment-related differences would decline with further follow-up. CONCLUSION: External- beam radiotherapy of early prostate cancer is followed by bowel and bladder irritability, by increasingly severe sexual dysfunction and, in men aged more than 65 years, occasional urinary incontinence. Greater sexual dysfunction and urinary incontinence occur in the year following radical prostatectomy. These postsurgical complication rates from patient questionnaires are greater than have been reported in other treatment series and confirm the results of two retrospective studies of patient-reported complications.


This article has been cited by other articles:


Home page
 JCOHome page
J. A. Clark and J. A. Talcott
Confidence and Uncertainty Long After Initial Treatment for Early Prostate Cancer: Survivors' Views of Cancer Control and the Treatment Decisions They Made
J. Clin. Oncol., September 20, 2006; 24(27): 4457 - 4463.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
S. Namiki, S. Ishidoya, T. Tochigi, S. Kawamura, M. Kuwahara, A. Terai, K. Yoshimura, I. Numata, M. Satoh, S. Saito, et al.
Health-Related Quality of Life after Intensity Modulated Radiation Therapy for Localized Prostate Cancer: Comparison with Conventional and Conformal Radiotherapy
Jpn. J. Clin. Oncol., April 1, 2006; 36(4): 224 - 230.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
S. Namiki, S. Saito, M. Satoh, S. Ishidoya, S. Kawamura, T. Tochigi, M. Kuwahara, M. Aizawa, N. Ioritani, K. Yoshimura, et al.
Quality of Life after Radical Prostatectomy in Japanese Men: 2 year Longitudinal Study
Jpn. J. Clin. Oncol., September 1, 2005; 35(9): 551 - 558.
[Abstract] [Full Text] [PDF]

Home page
 Eval Health ProfHome page
D. T. Eton, J.-S. Lai, D. Cella, B. B. Reeve, J. A. Talcott, J. A. Clark, C. P. McPherson, M. S. Litwin, and C. M. Moinpour
Data Pooling and Analysis to Build a Preliminary Item Bank: An Example Using Bowel Function in Prostate Cancer
Eval Health Prof, June 1, 2005; 28(2): 142 - 159.
[Abstract] [PDF]

Home page
 JCOHome page
D. C. Miller, M. G. Sanda, R. L. Dunn, J. E. Montie, H. Pimentel, H. M. Sandler, W. P. McLaughlin, and J. T. Wei
Long-Term Outcomes Among Localized Prostate Cancer Survivors: Health-Related Quality-of-Life Changes After Radical Prostatectomy, External Radiation, and Brachytherapy
J. Clin. Oncol., April 20, 2005; 23(12): 2772 - 2780.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
T. K. Johnson, F. D. Gilliland, R. M. Hoffman, D. Deapen, D. F. Penson, J. L. Stanford, P. C. Albertsen, and A. S. Hamilton
Racial/Ethnic Differences in Functional Outcomes in the 5 Years After Diagnosis of Localized Prostate Cancer
J. Clin. Oncol., October 15, 2004; 22(20): 4193 - 4201.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
D. S. Kaufman, W. S. McDougal, A. L. Zietman, M. G. Harisinghani, and R. H. Young
Case 21-2004 - A 63-Year-Old Man with Metastatic Prostate Carcinoma Refractory to Hormone Therapy
N. Engl. J. Med., July 8, 2004; 351(2): 171 - 178.
[Full Text] [PDF]

Home page
 JCOHome page
J. A. Talcott, J. Manola, J. A. Clark, I. Kaplan, C. J. Beard, S. P. Mitchell, R. C. Chen, M. P. O'Leary, P. W. Kantoff, and A. V. D'Amico
Time Course and Predictors of Symptoms After Primary Prostate Cancer Therapy
J. Clin. Oncol., November 1, 2003; 21(21): 3979 - 3986.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. M.H. Alibhai, G. Naglie, R. Nam, J. Trachtenberg, and M. D. Krahn
Do Older Men Benefit From Curative Therapy of Localized Prostate Cancer?
J. Clin. Oncol., September 1, 2003; 21(17): 3318 - 3327.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
B. A. Spencer, M. Steinberg, J. Malin, J. Adams, and M. S. Litwin
Quality-of-Care Indicators for Early-Stage Prostate Cancer
J. Clin. Oncol., May 15, 2003; 21(10): 1928 - 1936.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. F. Penson, Z. Feng, A. Kuniyuki, D. McClerran, P. C. Albertsen, D. Deapen, F. Gilliland, R. Hoffman, R. A. Stephenson, A. L. Potosky, et al.
General Quality of Life 2 Years Following Treatment for Prostate Cancer: What Influences Outcomes? Results From the Prostate Cancer Outcomes Study
J. Clin. Oncol., March 15, 2003; 21(6): 1147 - 1154.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
R. Harris and K. N. Lohr
Screening for Prostate Cancer: An Update of the Evidence for the U.S. Preventive Services Task Force
Ann Intern Med, December 3, 2002; 137(11): 917 - 929.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. H. Burkhardt, M. S. Litwin, C. M. Rose, R. J. Correa, J. H. Sunshine, C. Hogan, and J. A. Hayman
Comparing the Costs of Radiation Therapy and Radical Prostatectomy for the Initial Treatment of Early-Stage Prostate Cancer
J. Clin. Oncol., June 15, 2002; 20(12): 2869 - 2875.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. L. Potosky, B. B. Reeve, L. X. Clegg, R. M. Hoffman, R. A. Stephenson, P. C. Albertsen, F. D. Gilliland, and J. L. Stanford
Quality of Life Following Localized Prostate Cancer Treated Initially with Androgen Deprivation Therapy or No Therapy
J Natl Cancer Inst, March 20, 2002; 94(6): 430 - 437.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. T. Wei, R. L. Dunn, H. M. Sandler, P. W. McLaughlin, J. E. Montie, M. S. Litwin, L. Nyquist, and M. G. Sanda
Comprehensive Comparison of Health-Related Quality of Life After Contemporary Therapies for Localized Prostate Cancer
J. Clin. Oncol., January 15, 2002; 20(2): 557 - 566.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
L. C. Harlan, A. Potosky, F. D. Gilliland, R. Hoffman, P. C. Albertsen, A. S. Hamilton, J. W. Eley, J. L. Stanford, and R. A. Stephenson
Factors Associated With Initial Therapy for Clinically Localized Prostate Cancer: Prostate Cancer Outcomes Study
J Natl Cancer Inst, December 19, 2001; 93(24): 1864 - 1871.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. L. Potosky, K. Knopf, L. X. Clegg, P. C. Albertsen, J. L. Stanford, A. S. Hamilton, F. D. Gilliland, J. W. Eley, R. A. Stephenson, and R. M. Hoffman
Quality-of-Life Outcomes After Primary Androgen Deprivation Therapy: Results From the Prostate Cancer Outcomes Study
J. Clin. Oncol., September 1, 2001; 19(17): 3750 - 3757.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. S. Hamilton, J. L. Stanford, F. D. Gilliland, P. C. Albertsen, R. A. Stephenson, R. M. Hoffman, J. W. Eley, L. C. Harlan, and A. L. Potosky
Health Outcomes After External-Beam Radiation Therapy for Clinically Localized Prostate Cancer: Results From the Prostate Cancer Outcomes Study
J. Clin. Oncol., May 1, 2001; 19(9): 2517 - 2526.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
P. A. Ganz and M. S. Litwin
Prostate Cancer: The Price of Early Detection
J. Clin. Oncol., March 15, 2001; 19(6): 1587 - 1588.
[Full Text] [PDF]

Home page
 JCOHome page
J. B. Madalinska, M.-L. Essink-Bot, H. J. de Koning, W. J. Kirkels, P. J. van der Maas, and F. H. Schroder
Health-Related Quality-of-Life Effects of Radical Prostatectomy and Primary Radiotherapy for Screen-Detected or Clinically Diagnosed Localized Prostate Cancer
J. Clin. Oncol., March 15, 2001; 19(6): 1619 - 1628.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
E. J. Small, M. W. Frohlich, R. Bok, K. Shinohara, G. Grossfeld, Z. Rozenblat, Wm. K. Kelly, M. Corry, and D. M. Reese
Prospective Trial of the Herbal Supplement PC-SPES in Patients With Progressive Prostate Cancer
J. Clin. Oncol., November 1, 2000; 18(21): 3595 - 3603.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
R. T. Penson, J. Gallagher, M. E. Gioiella, M. Wallace, K. Borden, L. A. Duska, J. A. Talcott, F. J. McGovern, L. J. Appleman, B. A. Chabner, et al.
Sexuality and Cancer: Conversation Comfort Zone
Oncologist, August 1, 2000; 5(4): 336 - 344.
[Abstract] [Full Text]

Home page
 JAMAHome page
T. J. Wilt
Uncertainty in Prostate Cancer Care: The Physician's Role in Clearing the Confusion
JAMA, June 28, 2000; 283(24): 3258 - 3260.
[Full Text] [PDF]

Home page
 PsychosomaticsHome page
E. J.S. Kunkel, J. R. Bakker, R. E. Myers, O. Oyesanmi, and L. G. Gomella
Biopsychosocial Aspects of Prostate Cancer
Psychosomatics, April 1, 2000; 41(2): 85 - 94.
[Abstract] [Full Text]

Home page
 JAMAHome page
J. L. Stanford, Z. Feng, A. S. Hamilton, F. D. Gilliland, R. A. Stephenson, J. W. Eley, P. C. Albertsen, L. C. Harlan, and A. L. Potosky
Urinary and Sexual Function After Radical Prostatectomy for Clinically Localized Prostate Cancer: The Prostate Cancer Outcomes Study
JAMA, January 19, 2000; 283(3): 354 - 360.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. C. Weber, S. Bieri, J. M. Kurtz, and R. Miralbell
Prospective Pilot Study of Sildenafil for Treatment of Postradiotherapy Erectile Dysfunction in Patients With Prostate Cancer
J. Clin. Oncol., November 1, 1999; 17(11): 3444 - 3449.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. L. Potosky, L. C. Harlan, J. L. Stanford, F. D. Gilliland, A. S. Hamilton, P. C. Albertsen, J. W. Eley, J. M. Liff, D. Deapen, R. A. Stephenson, et al.
Prostate Cancer Practice Patterns and Quality of Life: the Prostate Cancer Outcomes Study
J Natl Cancer Inst, October 20, 1999; 91(20): 1719 - 1724.
[Full Text] [PDF]


About
JCO		 Editorial
Roster		 Advertising
Information		 Librarians &
Institutions		 Rights &
Permissions		 Site Map

Copyright © 1998 by the American Society of Clinical Oncology, Online ISSN: 1527-7755. Print ISSN: 0732-183X
Terms and Conditions of Use
  HighWire Press HighWire Press™ assists in the publication of JCO Online