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Expression of BAG-1 in Invasive Breast Carcinomas

From the Departments of Medicine and Pathology, the Division of Community Healthy, and Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, and Newfoundland Cancer Treatment and Research Foundation, Dr H. Bliss Murphy Cancer Centre, St. John's, Newfoundland, Canada.

Address reprint requests to Shou-Ching Tang, MD, PhD, Newfoundland Cancer Treatment and Research Foundation, Dr H. Bliss Murphy Cancer Centre, 300 Prince Philip Dr, St. John's, NF, Canada A1B 3V6; email stang{at}nctrf.nf.ca

PURPOSE: The purpose of this study was to retrospectively evaluate the expression of BAG-1 in invasive breast carcinomas. The intensity and subcellular distribution of BAG-1 expression was correlated with conventional prognostic factors and with disease-free and overall survival.

PATIENTS AND METHODS: One hundred forty patients diagnosed with invasive breast cancer in St. John's, Newfoundland, between 1986 and 1996 were included in the study. The median follow-up of the study was 8 years. Expression of BAG-1 was determined by immunohistochemical staining of paraffin-embedded breast tumor tissues.

RESULTS: Of the 140 breast carcinomas examined, 77.1% were positive for BAG-1 expression. Except for differentiation, no correlation was observed between BAG-1 expression and conventional prognostic factors such as age, histology, stage, and estrogen and progesterone receptor status. In multivariate analysis, BAG-1 expression was significantly associated with shorter disease-free (P = .0052) and overall survival (P = .0033). Patients whose tumors expressed nuclear BAG-1 tended to have a shorter disease-free (63 v 84 months; P = 0.4493) and overall (69 v 99 months, P = .1009) survival.

CONCLUSION: BAG-1 is overexpressed in the majority of invasive breast carcinomas. Although BAG-1 did not correlate with conventional prognostic factors, its overexpression, especially the nuclear expression, may be associated with a shorter disease-free and overall survival. Our preliminary data strongly indicate that further investigation is warranted to define the role of BAG-1 as an independent prognostic factor in patients with newly diagnosed breast cancer.

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