Advertisement
Journal of Clinical Oncology  
Search for:
Limit by:
  Browse by Subject or Issue
Home Search or Browse JCO My JCO Subscriptions Customer Service Site Map

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Save to my personal folders
Right arrow Download to citation manager
Right arrowRights & Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Furuse, K.
Right arrow Articles by Ariyoshi, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Furuse, K.
Right arrow Articles by Ariyoshi, Y.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
Journal of Clinical Oncology, Vol 17, Issue 9 (September), 1999: 2692
© 1999 American Society for Clinical Oncology

Phase III Study of Concurrent Versus Sequential Thoracic Radiotherapy in Combination With Mitomycin, Vindesine, and Cisplatin in Unresectable Stage III Non–Small-Cell Lung Cancer

Kiyoyuki Furuse, Masahiro Fukuoka, Masaaki Kawahara, Hideki Nishikawa, Yoshiki Takada, Shinzoh Kudoh, Nobuyuki Katagami, Yutaka Ariyoshi, for the West Japan Lung Cancer Group

From the Department of Internal Medicine, National Kinki Central Hospital for Chest Diseases; Department 2 of Internal Medicine, Osaka Prefectural Habikino Hospital; Department of Internal Medicine, National Toneyama Hospital for Chest Diseases; Department 1 of Internal Medicine, Osaka City University; and Department of Respiratory Disease, Osaka Medical Center Cancer and Cardiovascular Diseases, Osaka; Department of Radiology, Hyogo Medical Center for Adults, Hyogo; Department of Respiratory Disease, Kobe City General Hospital, Kobe; and Department of Respiratory Disease, Aichi Cancer Center, Nagoya, Japan.

Address reprint requests to Kiyoyuki Furuse, MD, Office of the Consultant, Division of Respiratory Diseases, Health Insurance Union, Osaka Central Hospital, 3-3-17, Niwashirodai, Sakai, Osaka 590-0133 Japan.

PURPOSE: A phase III study was performed to determine whether concurrent or sequential treatment with radiotherapy (RT) and chemotherapy (CT) improves survival in unresectable stage III non–small-cell lung cancer (NSCLC).

PATIENTS AND METHODS: Patients were assigned to the two treatment arms. In the concurrent arm, chemotherapy consisted of cisplatin (80 mg/m2 on days 1 and 29), vindesine (3 mg/m2 on days 1, 8, 29, and 36), and mitomycin (8 mg/m2 on days 1 and 29). RT began on day 2 at a dose of 28 Gy (2 Gy per fraction and 5 fractions per week for a total of 14 fractions) followed by a rest period of 10 days, and then repeated. In the sequential arm, the same CT was given, but RT was initiated after completing CT and consisted of 56 Gy (2 Gy per fraction and 5 fractions per week for a total of 28 fractions).

RESULTS: Three hundred twenty patients were entered onto the study. Pretreatment characteristics were well balanced between the treatment arms. The response rate for the concurrent arm was significantly higher (84.0%) than that of the sequential arm (66%) (P = .0002). The median survival duration was significantly superior in patients receiving concurrent therapy (16.5 months), as compared with those receiving sequential therapy (13.3 months) (P = .03998). Two-, 3-, 4-, and 5-year survival rates in the concurrent group (34.6%, 22.3%, 16.9%, and 15.8%, respectively) were better than those in the sequential group (27.4%, 14.7%, 10.1%, and 8.9%, respectively). Myelosuppression was significantly greater among patients on the concurrent arm than on the sequential arm (P = .0001).

CONCLUSION: In selected patients with unresectable stage III NSCLC, the concurrent approach yields a significantly increased response rate and enhanced median survival duration when compared with the sequential approach.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Jpn J Clin OncolHome page
T. Fujii, H. Kunikane, H. Okamoto, K. Watanabe, H. Kunitoh, K. Mori, A. Yokoyama, H. Fukuda, T. Tamura, and N. Saijo
A Phase II Study of Cisplatin and Irinotecan as Induction Chemotherapy Followed by Accelerated Hyperfractionated Thoracic Radiotherapy with Daily Low-dose Carboplatin in Unresectable Stage III Non-small Cell Lung Cancer: JCOG 9510
Jpn. J. Clin. Oncol., September 20, 2009; (2009) hyp102v1.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
A. G. Pallis, C. Gridelli, J. P. van Meerbeeck, L. Greillier, U. Wedding, D. Lacombe, J. Welch, C. P. Belani, and M. Aapro
EORTC Elderly Task Force and Lung Cancer Group and International Society for Geriatric Oncology (SIOG) experts' opinion for the treatment of non-small-cell lung cancer in an elderly population
Ann. Onc., August 28, 2009; (2009) mdp360v1.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
V. Steger, T. Walles, B. Kosan, T. Walker, T. Kyriss, S. Veit, J. Dippon, and G. Friedel
Trimodal Therapy for Histologically Proven N2/3 Non-Small Cell Lung Cancer: Mid-Term Results and Indicators for Survival.
Ann. Thorac. Surg., June 1, 2009; 87(6): 1676 - 1683.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
G. D'Addario, E. Felip, and On behalf of the ESMO Guidelines Working Group
Non-small-cell lung cancer: ESMO Clinical Recommendations for diagnosis, treatment and follow-up
Ann. Onc., May 1, 2009; 20(suppl_4): iv68 - iv70.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Sak, S. Grehl, M. Engelhard, A. Wierlemann, H.-P. Kaelberlah, P. Erichsen, C. Pottgen, M. Groneberg, and M. Stuschke
Long-Term In vivo Effects of Cisplatin on {gamma}-H2AX Foci Signaling in Peripheral Lymphocytes of Tumor Patients After Irradiation
Clin. Cancer Res., April 15, 2009; 15(8): 2927 - 2934.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
R. J. Cerfolio, A. S. Bryant, V. L. Jones, and R. M. Cerfolio
Pulmonary resection after concurrent chemotherapy and high dose (60 Gy) radiation for non-small cell lung cancer is safe and may provide increased survival
Eur. J. Cardiothorac. Surg., April 1, 2009; 35(4): 718 - 723.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. Mutter, B. Lu, D. P. Carbone, I. Csiki, L. Moretti, D. H. Johnson, J. D. Morrow, A. B. Sandler, Y. Shyr, F. Ye, et al.
A Phase II Study of Celecoxib in Combination with Paclitaxel, Carboplatin, and Radiotherapy for Patients with Inoperable Stage IIIA/B Non-Small Cell Lung Cancer
Clin. Cancer Res., March 15, 2009; 15(6): 2158 - 2165.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. J. Beitler and J. S. Cooper
Seduction by Induction?
J. Clin. Oncol., January 1, 2009; 27(1): 9 - 10.
[Full Text] [PDF]

Home page
 Ann OncolHome page
D. D. Ruysscher, A. Botterweck, M. Dirx, M. Pijls-Johannesma, R. Wanders, M. Hochstenbag, A.-M. C. Dingemans, G. Bootsma, W. Geraedts, J. Simons, et al.
Eligibility for concurrent chemotherapy and radiotherapy of locally advanced lung cancer patients: a prospective, population-based study
Ann. Onc., January 1, 2009; 20(1): 98 - 102.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
N. Hanna, M. Neubauer, C. Yiannoutsos, R. McGarry, J. Arseneau, R. Ansari, C. Reynolds, R. Govindan, A. Melnyk, W. Fisher, et al.
Phase III Study of Cisplatin, Etoposide, and Concurrent Chest Radiation With or Without Consolidation Docetaxel in Patients With Inoperable Stage III Non-Small-Cell Lung Cancer: The Hoosier Oncology Group and U.S. Oncology
J. Clin. Oncol., December 10, 2008; 26(35): 5755 - 5760.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. E. Bauman, M. S. Mulligan, R. G. Martins, B. F. Kurland, K. D. Eaton, and D. E. Wood
Salvage Lung Resection After Definitive Radiation (>59 Gy) for Non-Small Cell Lung Cancer: Surgical and Oncologic Outcomes
Ann. Thorac. Surg., November 1, 2008; 86(5): 1632 - 1639.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. J. Edelman, M. Suntharalingam, W. Burrows, K. F. Kwong, N. Mitra, Z. Gamliel, M. Riley, L. B. Cooper, N. L. Kennedy, S. Buskirk, et al.
Phase I/II Trial of Hyperfractionated Radiation and Chemotherapy Followed by Surgery in Stage III Lung Cancer
Ann. Thorac. Surg., September 1, 2008; 86(3): 903 - 910.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. A. Socinski, A. W. Blackstock, J. A. Bogart, X. Wang, M. Munley, J. Rosenman, L. Gu, G. A. Masters, P. Ungaro, A. Sleeper, et al.
Randomized Phase II Trial of Induction Chemotherapy Followed by Concurrent Chemotherapy and Dose-Escalated Thoracic Conformal Radiotherapy (74 Gy) in Stage III Non-Small-Cell Lung Cancer: CALGB 30105
J. Clin. Oncol., May 20, 2008; 26(15): 2457 - 2463.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
K. Rosenzweig
In Reply
J. Clin. Oncol., May 1, 2008; 26(13): 2235 - 2236.
[Full Text] [PDF]

Home page
 Mayo Clin Proc.Home page
J. R. Molina, P. Yang, S. D. Cassivi, S. E. Schild, and A. A. Adjei
Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship
Mayo Clin. Proc., May 1, 2008; 83(5): 584 - 594.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
H. Kunitoh, H. Kato, M. Tsuboi, T. Shibata, H. Asamura, Y. Ichonose, N. Katakami, K. Nagai, T. Mitsudomi, A. Matsumura, et al.
Phase II Trial of Preoperative Chemoradiotherapy Followed by Surgical Resection in Patients With Superior Sulcus Non-Small-Cell Lung Cancers: Report of Japan Clinical Oncology Group Trial 9806
J. Clin. Oncol., February 1, 2008; 26(4): 644 - 649.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
P. A. Kosmidis, H. P. Kalofonos, C. Christodoulou, K. Syrigos, T. Makatsoris, D. Skarlos, C. Bakogiannis, C. Nicolaides, D. Bafaloukos, A. Bamias, et al.
Paclitaxel and gemcitabine versus carboplatin and gemcitabine in patients with advanced non-small-cell lung cancer. A phase III study of the Hellenic Cooperative Oncology Group
Ann. Onc., January 1, 2008; 19(1): 115 - 122.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R. Glynne-Jones and P. Hoskin
Neoadjuvant Cisplatin Chemotherapy Before Chemoradiation: A Flawed Paradigm?
J. Clin. Oncol., November 20, 2007; 25(33): 5281 - 5286.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. W. Blackstock and R. Govindan
Definitive Chemoradiation for the Treatment of Locally Advanced Non Small-Cell Lung Cancer
J. Clin. Oncol., September 10, 2007; 25(26): 4146 - 4152.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. A. Robinson, J. C. Ruckdeschel, H. Wagner Jr, and C. W. Stevens
Treatment of Non-small Cell Lung Cancer-Stage IIIA: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition)
Chest, September 1, 2007; 132(3_suppl): 243S - 265S.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. R. Jett, S. E. Schild, R. L. Keith, and K. A. Kesler
Treatment of Non-small Cell Lung Cancer, Stage IIIB: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition)
Chest, September 1, 2007; 132(3_suppl): 266S - 276S.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. Gridelli, C. Langer, P. Maione, A. Rossi, and S. E. Schild
Lung Cancer in the Elderly
J. Clin. Oncol., May 10, 2007; 25(14): 1898 - 1907.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
E. E. Vokes, J. E. Herndon II, M. J. Kelley, M. G. Cicchetti, N. Ramnath, H. Neill, J. N. Atkins, D. M. Watson, W. Akerley, and M. R. Green
Induction Chemotherapy Followed by Chemoradiotherapy Compared With Chemoradiotherapy Alone for Regionally Advanced Unresectable Stage III Non-Small-Cell Lung Cancer: Cancer and Leukemia Group B
J. Clin. Oncol., May 1, 2007; 25(13): 1698 - 1704.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
D De Ruysscher, C Dehing, R-H Bremer, S. Bentzen, F Koppe, M Pijls-Johannesma, L Harzee, A Minken, R Wanders, M Hochstenbag, et al.
Maximal neutropenia during chemotherapy and radiotherapy is significantly associated with the development of acute radiation-induced dysphagia in lung cancer patients
Ann. Onc., May 1, 2007; 18(5): 909 - 916.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
I. Sekine, M. Sumi, Y. Ito, T. Kato, Y. Fujisaka, H. Nokihara, N. Yamamoto, H. Kunitoh, Y. Ohe, and T. Tamura
Phase I Study of Cisplatin Analogue Nedaplatin, Paclitaxel, and Thoracic Radiotherapy for Unresectable Stage III Non-Small Cell Lung Cancer
Jpn. J. Clin. Oncol., April 23, 2007; (2007) hym008v1.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Y. Seiwert, P. P. Connell, A. M. Mauer, P. C. Hoffman, C. M. George, L. Szeto, R. Salgia, K. E. Posther, B. Nguyen, D. J. Haraf, et al.
A Phase I Study of Pemetrexed, Carboplatin, and Concurrent Radiotherapy in Patients with Locally Advanced or Metastatic Non-Small Cell Lung or Esophageal Cancer
Clin. Cancer Res., January 15, 2007; 13(2): 515 - 522.
[Abstract] [Full Text] [PDF]

Home page
 American Journal of Medical QualityHome page
C.-R. Chien and M.-S. Lai
Trends in the Pattern of Care for Lung Cancer and Their Correlation With New Clinical Evidence: Experiences in a University-Affiliated Medical Center
American Journal of Medical Quality, November 1, 2006; 21(6): 408 - 414.
[Abstract] [PDF]

Home page
 ChestHome page
J. R. Molina, A. A. Adjei, and J. R. Jett
Advances in Chemotherapy of Non-small Cell Lung Cancer.
Chest, October 1, 2006; 130(4): 1211 - 1219.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R. M. Huber, M. Flentje, M. Schmidt, B. Pollinger, H. Gosse, J. Willner, and K. Ulm
Simultaneous Chemoradiotherapy Compared With Radiotherapy Alone After Induction Chemotherapy in Inoperable Stage IIIA or IIIB Non-Small-Cell Lung Cancer: Study CTRT99/97 by the Bronchial Carcinoma Therapy Group
J. Clin. Oncol., September 20, 2006; 24(27): 4397 - 4404.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
A. Vergnenegre, C. Combescure, P. Fournel, S. Bayle, C. Gimenez, P. J. Souquet, H. Lena, M. Perol, J. Y. Delhoume, and GFPC (Groupe Francais de Pneumo-Cancerologie)
Cost-minimization analysis of a phase III trial comparing concurrent versus sequential radiochemotherapy for locally advanced non-small-cell lung cancer (GFPC-GLOT 95-01)
Ann. Onc., August 1, 2006; 17(8): 1269 - 1274.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
T. E. Stinchcombe, D. Fried, D. E. Morris, and M. A. Socinski
Combined Modality Therapy for Stage III Non-Small Cell Lung Cancer
Oncologist, July 1, 2006; 11(7): 809 - 823.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
A. Auperin, C. Le Pechoux, J. P. Pignon, C. Koning, B. Jeremic, G. Clamon, L. Einhorn, D. Ball, M. G. Trovo, H. J. M. Groen, et al.
Concomitant radio-chemotherapy based on platin compounds in patients with locally advanced non-small cell lung cancer (NSCLC): A meta-analysis of individual data from 1764 patients
Ann. Onc., March 1, 2006; 17(3): 473 - 483.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. K. Williamson, J. J. Crowley, P. N. Lara Jr, J. McCoy, D. H.M. Lau, R. W. Tucker, G. M. Mills, and D. R. Gandara
Phase III Trial of Paclitaxel Plus Carboplatin With or Without Tirapazamine in Advanced Non-Small-Cell Lung Cancer: Southwest Oncology Group Trial S0003
J. Clin. Oncol., December 20, 2005; 23(36): 9097 - 9104.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. Arpin, D. Perol, J.-Y. Blay, L. Falchero, L. Claude, S. Vuillermoz-Blas, I. Martel-Lafay, C. Ginestet, L. Alberti, D. Nosov, et al.
Early Variations of Circulating Interleukin-6 and Interleukin-10 Levels During Thoracic Radiotherapy Are Predictive for Radiation Pneumonitis
J. Clin. Oncol., December 1, 2005; 23(34): 8748 - 8756.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. J. Cerfolio, A. S. Bryant, S. A. Spencer, and A. A. Bartolucci
Pulmonary Resection After High-Dose and Low-Dose Chest Irradiation
Ann. Thorac. Surg., October 1, 2005; 80(4): 1224 - 1230.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. G. Divers, S. A. Spencer, D. Carey, E. M. Busby, M. D. Hyatt, and F. Robert
Phase I/IIa Study of Cisplatin and Gemcitabine As Induction Chemotherapy Followed by Concurrent Chemoradiotherapy With Gemcitabine and Paclitaxel for Locally Advanced Non-Small-Cell Lung Cancer
J. Clin. Oncol., September 20, 2005; 23(27): 6664 - 6673.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. Wee, E. H. Tan, B. C. Tai, H. B. Wong, S. S. Leong, T. Tan, E. T. Chua, E. Yang, K. M. Lee, K. W. Fong, et al.
Randomized Trial of Radiotherapy Versus Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy in Patients With American Joint Committee on Cancer/International Union Against Cancer Stage III and IV Nasopharyngeal Cancer of the Endemic Variety
J. Clin. Oncol., September 20, 2005; 23(27): 6730 - 6738.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
E. E. Vokes
Optimal Therapy for Unresectable Stage III Non-Small-Cell Lung Cancer
J. Clin. Oncol., September 1, 2005; 23(25): 5853 - 5855.
[Full Text] [PDF]

Home page
 JCOHome page
B. Movsas
Will Future Progress in Non-Small-Cell Lung Cancer Be Step by Step ... or by Leaps and Bounds?
J. Clin. Oncol., September 1, 2005; 23(25): 5859 - 5861.
[Full Text] [PDF]

Home page
 JCOHome page
P. Fournel, G. Robinet, P. Thomas, P.-J. Souquet, H. Lena, A. Vergnenegre, J.-Y. Delhoume, J. Le Treut, J.-A. Silvani, E. Dansin, et al.
Randomized Phase III Trial of Sequential Chemoradiotherapy Compared With Concurrent Chemoradiotherapy in Locally Advanced Non-Small-Cell Lung Cancer: Groupe Lyon-Saint-Etienne d'Oncologie Thoracique-Groupe Francais de Pneumo-Cancerologie NPC 95-01 Study
J. Clin. Oncol., September 1, 2005; 23(25): 5910 - 5917.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. P. Belani, H. Choy, P. Bonomi, C. Scott, P. Travis, J. Haluschak, and W. J. Curran Jr
Combined Chemoradiotherapy Regimens of Paclitaxel and Carboplatin for Locally Advanced Non-Small-Cell Lung Cancer: A Randomized Phase II Locally Advanced Multi-Modality Protocol
J. Clin. Oncol., September 1, 2005; 23(25): 5883 - 5891.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. G. Spiro and G. A. Silvestri
One Hundred Years of Lung Cancer
Am. J. Respir. Crit. Care Med., September 1, 2005; 172(5): 523 - 529.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. M. Muanza, A. P. Cotrim, M. McAuliffe, A. L. Sowers, B. J. Baum, J. A. Cook, F. Feldchtein, P. Amazeen, C. N. Coleman, and J. B. Mitchell
Evaluation of Radiation-Induced Oral Mucositis by Optical Coherence Tomography
Clin. Cancer Res., July 15, 2005; 11(14): 5121 - 5127.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. E. Vokes, J. Crawford, J. Bogart, M. A. Socinski, G. Clamon, and M. R. Green
Concurrent Chemoradiotherapy for Unresectable Stage III Non-Small Cell Lung Cancer
Clin. Cancer Res., July 1, 2005; 11(13): 5045s - 5050s.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Thatcher, C. Faivre-Finn, F. Blackhall, H. Anderson, and P. Lorigan
Sequential Platinum-Based Chemotherapy-Thoracic Radiotherapy in Early Stage Non-Small Cell Lung Cancer
Clin. Cancer Res., July 1, 2005; 11(13): 5051s - 5056s.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. P. Belani, W. Wang, D. H. Johnson, H. Wagner, J. Schiller, M. Veeder, and M. Mehta
Phase III Study of the Eastern Cooperative Oncology Group (ECOG 2597): Induction Chemotherapy Followed by Either Standard Thoracic Radiotherapy or Hyperfractionated Accelerated Radiotherapy for Patients With Unresectable Stage IIIA and B Non-Small-Cell Lung Cancer
J. Clin. Oncol., June 1, 2005; 23(16): 3760 - 3767.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
L. K. Shankar and D. C. Sullivan
Functional Imaging in Lung Cancer
J. Clin. Oncol., May 10, 2005; 23(14): 3203 - 3211.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. Farray, N. Mirkovic, and K. S. Albain
Multimodality Therapy for Stage III Non-Small-Cell Lung Cancer
J. Clin. Oncol., May 10, 2005; 23(14): 3257 - 3269.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
M. Izmirli, F. Yaman, M. Y. Buyukpolat, A. Yoney, and M. Unsal
An Accelerated Radiotherapy Scheme Using a Concomitant Boost Technique for the Treatment of Unresectable Stage III Non-small Cell Lung Cancer
Jpn. J. Clin. Oncol., May 1, 2005; 35(5): 239 - 244.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Z. Liao, R. Komaki, L. Milas, C. Yuan, M. Kies, J. Y. Chang, M. Jeter, T. Guerrero, G. Blumenschien, C. M. Smith, et al.
A Phase I Clinical Trial of Thoracic Radiotherapy and Concurrent Celecoxib for Patients with Unfavorable Performance Status Inoperable/Unresectable Non-Small Cell Lung Cancer
Clin. Cancer Res., May 1, 2005; 11(9): 3342 - 3348.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
B. Movsas, C. Scott, C. Langer, M. Werner-Wasik, N. Nicolaou, R. Komaki, M. Machtay, C. Smith, R. Axelrod, L. Sarna, et al.
Randomized Trial of Amifostine in Locally Advanced Non-Small-Cell Lung Cancer Patients Receiving Chemotherapy and Hyperfractionated Radiation: Radiation Therapy Oncology Group Trial 98-01
J. Clin. Oncol., April 1, 2005; 23(10): 2145 - 2154.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
H. J. Mamon, B. Y. Yeap, P. A. Janne, J. Reblando, S. Shrager, M. T. Jaklitsch, S. Mentzer, J. M. Lukanich, D. J. Sugarbaker, E. H. Baldini, et al.
High Risk of Brain Metastases in Surgically Staged IIIA Non-Small-Cell Lung Cancer Patients Treated With Surgery, Chemotherapy, and Radiation
J. Clin. Oncol., March 1, 2005; 23(7): 1530 - 1537.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
B. Jeremic, B. Milicic, L. Acimovic, and S. Milisavljevic
Concurrent Hyperfractionated Radiotherapy and Low-Dose Daily Carboplatin and Paclitaxel in Patients With Stage III Non-Small-Cell Lung Cancer: Long-Term Results of a Phase II Study
J. Clin. Oncol., February 20, 2005; 23(6): 1144 - 1151.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. Raben, B. Helfrich, D. C. Chan, F. Ciardiello, L. Zhao, W. Franklin, A. E. Baron, C. Zeng, T. K. Johnson, and P. A. Bunn Jr
The Effects of Cetuximab Alone and in Combination With Radiation and/or Chemotherapy in Lung Cancer
Clin. Cancer Res., January 15, 2005; 11(2): 795 - 805.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
L. K. Kvols
Radiation Sensitizers: A Selective Review of Molecules Targeting DNA and non-DNA Targets
J. Nucl. Med., January 1, 2005; 46(1_suppl): 187S - 190S.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
L. B. Marks, J. Garst, M. A. Socinski, G. Sibley, A. W. Blackstock, J. E. H. S. Zhou, T. Shafman, A. Tisch, R. Clough, X. Yu, et al.
Carboplatin/Paclitaxel or Carboplatin/Vinorelbine Followed by Accelerated Hyperfractionated Conformal Radiation Therapy: Report of a Prospective Phase I Dose Escalation Trial From the Carolina Conformal Therapy Consortium
J. Clin. Oncol., November 1, 2004; 22(21): 4329 - 4340.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. A. Socinski, D. E. Morris, J. S. Halle, D. T. Moore, T. A. Hensing, S. A. Limentani, R. Fraser, M. Tynan, A. Mears, M. P. Rivera, et al.
Induction and Concurrent Chemotherapy With High-Dose Thoracic Conformal Radiation Therapy in Unresectable Stage IIIA and IIIB Non-Small-Cell Lung Cancer: A Dose-Escalation Phase I Trial
J. Clin. Oncol., November 1, 2004; 22(21): 4341 - 4350.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
Y. Hasegawa, S. Takanashi, K. Okudera, M. Aoki, K. Basaki, H. Kondo, T. Takahata, N. Yasui-Furukori, T. Tateishi, Y. Abe, et al.
Weekly Paclitaxel and Nedaplatin With Concurrent Radiotherapy for Locally Advanced Non-small-cell Lung Cancer: a Phase I/II Study
Jpn. J. Clin. Oncol., November 1, 2004; 34(11): 647 - 653.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
K. Suzuki, H. Asamura, S.-i. Watanabe, and R. Tsuchiya
Combined Resection of Superior Vena Cava for Lung Carcinoma: Prognostic Significance of Patterns of Superior Vena Cava Invasion
Ann. Thorac. Surg., October 1, 2004; 78(4): 1184 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
B. Jeremic
Reply to the article "Continuously infused carboplatin used as radiosensitizer in locally unresectable non-small-cell lung cancer: a multicenter phase III study", by Groen et al. (Ann Oncol 2004; 15: 427-432)
Ann. Onc., August 1, 2004; 15(8): 1298 - 1299.
[Full Text] [PDF]

Home page
 Ann OncolHome page
M. A. Socinski, C. Zhang, J. E. Herndon II, R. O. Dillman, G. Clamon, E. Vokes, W. Akerley, J. Crawford, M. C. Perry, S. L. Seagren, et al.
Combined modality trials of the Cancer and Leukemia Group B in stage III non-small-cell lung cancer: analysis of factors influencing survival and toxicity
Ann. Onc., July 1, 2004; 15(7): 1033 - 1041.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Ichinose, Y. Nakai, S. Kudoh, H. Semba, S. Yoshida, T. Nukiwa, H. Yamamoto, Y. Yamane, and H. Niitani
Uracil/Tegafur Plus Cisplatin with Concurrent Radiotherapy for Locally Advanced Non-Small-Cell Lung Cancer: A Multi-institutional Phase II Trial
Clin. Cancer Res., July 1, 2004; 10(13): 4369 - 4373.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. S. Friedberg, R. Mick, J. P. Stevenson, T. Zhu, T. M. Busch, D. Shin, D. Smith, M. Culligan, A. Dimofte, E. Glatstein, et al.
Phase II Trial of Pleural Photodynamic Therapy and Surgery for Patients With Non-Small-Cell Lung Cancer With Pleural Spread
J. Clin. Oncol., June 1, 2004; 22(11): 2192 - 2201.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
W. Eberhardt, M. Stuschke, and G. Stamatis
Preoperative chemoradiation approaches to locally advanced non-small-cell lung cancer: one man's pride, another man's burden?
Ann. Onc., March 1, 2004; 15(3): 365 - 367.
[Full Text] [PDF]

Home page
 Ann OncolHome page
J.-P. Sculier, J.-J. Lafitte, T. Berghmans, P. Van Houtte, J. Lecomte, J. Thiriaux, A. Efremidis, G. Koumakis, V. Giner, M. Richez, et al.
A phase III randomised study comparing two different dose-intensity regimens as induction chemotherapy followed by thoracic irradiation in patients with advanced locoregional non-small-cell lung cancer
Ann. Onc., March 1, 2004; 15(3): 399 - 409.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. Spira and D. S. Ettinger
Multidisciplinary Management of Lung Cancer
N. Engl. J. Med., January 22, 2004; 350(4): 379 - 392.
[Full Text] [PDF]

Home page
 JCOHome page
D. G. Pfister, D. H. Johnson, C. G. Azzoli, W. Sause, T. J. Smith, S. Baker Jr, J. Olak, D. Stover, J. R. Strawn, A. T. Turrisi, et al.
American Society of Clinical Oncology Treatment of Unresectable Non-Small-Cell Lung Cancer Guideline: Update 2003
J. Clin. Oncol., January 15, 2004; 22(2): 330 - 353.
[Full Text] [PDF]

Home page
 JCOHome page
K. Kubota, K. Watanabe, H. Kunitoh, K. Noda, Y. Ichinose, N. Katakami, T. Sugiura, M. Kawahara, A. Yokoyama, S. Yokota, et al.
Phase III Randomized Trial of Docetaxel Plus Cisplatin Versus Vindesine Plus Cisplatin in Patients With Stage IV Non-Small-Cell Lung Cancer: The Japanese Taxotere Lung Cancer Study Group
J. Clin. Oncol., January 15, 2004; 22(2): 254 - 261.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
B. Movsas, J. Moughan, R. Komaki, H. Choy, R. Byhardt, C. Langer, M. Goldberg, M. Graham, D. Ettinger, D. Johnstone, et al.
Radiotherapy Patterns of Care Study in Lung Carcinoma
J. Clin. Oncol., December 15, 2003; 21(24): 4553 - 4559.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
Y. Ichinose, Y. Fukuyama, H. Asoh, C. Ushijima, T. Okamoto, J. Ikeda, J. Okamoto, and M. Sakai
Induction chemoradiotherapy and surgical resection for selected stage IIIB non-small-cell lung cancer
Ann. Thorac. Surg., December 1, 2003; 76(6): 1810 - 1814.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
B. Jeremic, F. B. Zimmermann, and M. Molls
Induction chemotherapy followed by concurrent chemoradiotherapy and operation in locally advanced non-small cell lung cancer
Ann. Thorac. Surg., September 1, 2003; 76(3): 979 - 979.
[Full Text] [PDF]

Home page
 JCOHome page
L. V. Sequist and T. J. Lynch
Aggressive Treatment for the Fit Elderly With Non-Small-Cell Lung Cancer? Yes!
J. Clin. Oncol., September 1, 2003; 21(17): 3186 - 3188.
[Full Text] [PDF]

Home page
 JCOHome page
S. E. Schild, P. J. Stella, S. M. Geyer, J. A. Bonner, W. L. McGinnis, J. A. Mailliard, J. Brindle, A. Jatoi, and J. R. Jett
The Outcome of Combined-Modality Therapy for Stage III Non-Small-Cell Lung Cancer in the Elderly
J. Clin. Oncol., September 1, 2003; 21(17): 3201 - 3206.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
R Booton, M Jones, and N Thatcher
Lung cancer * 7: Management of lung cancer in elderly patients
Thorax, August 1, 2003; 58(8): 711 - 720.
[Full Text] [PDF]

Home page
 The OncologistHome page
G. V. Scagliotti and A. T. Turrisi III
Docetaxel-Based Combined-Modality Chemoradiotherapy for Locally Advanced Non-Small Cell Lung Cancer
Oncologist, August 1, 2003; 8(4): 361 - 374.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. R. Gandara, K. Chansky, K. S. Albain, B. R. Leigh, L. E. Gaspar, P. N. Lara Jr, H. Burris, P. Gumerlock, J. P. Kuebler, J. D. Bearden III, et al.
Consolidation Docetaxel After Concurrent Chemoradiotherapy in Stage IIIB Non-Small-Cell Lung Cancer: Phase II Southwest Oncology Group Study S9504
J. Clin. Oncol., May 15, 2003; 21(10): 2004 - 2010.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A Price
Lung cancer * 5: State of the art radiotherapy for lung cancer
Thorax, May 1, 2003; 58(5): 447 - 452.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. J. Wirth, J. Lucca, P. Ostler, P. Fidias, C. Lynch, P. A. Janne, R. S. Herbst, B. E. Johnson, D. J. Sugarbaker, D. J. Mathisen, et al.
Induction Docetaxel and Carboplatin Followed by Weekly Docetaxel and Carboplatin with Concurrent Radiotherapy, then Surgery in Stage III Non-Small Cell Lung Cancer: A Phase I Study
Clin. Cancer Res., May 1, 2003; 9(5): 1698 - 1704.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. C. Formenti, M. Volm, K. A. Skinner, D. Spicer, D. Cohen, E. Perez, A. C. Bettini, S. Groshen, C. Gee, B. Florentine, et al.
Preoperative Twice-Weekly Paclitaxel With Concurrent Radiation Therapy Followed by Surgery and Postoperative Doxorubicin-Based Chemotherapy in Locally Advanced Breast Cancer: A Phase I/II Trial
J. Clin. Oncol., March 1, 2003; 21(5): 864 - 870.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Chen, K. Pandya, P. C. Keng, D. Johnstone, J. Li, Y.-J. Lee, T. Smudzin, and P. Okunieff
Phase I/II Clinical Study of Pulsed Paclitaxel Radiosensitization for Thoracic Malignancy: A Therapeutic Approach on the Basis of Preclinical Research of Human Cancer Cell Lines
Clin. Cancer Res., March 1, 2003; 9(3): 969 - 975.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. G. Swisher, J. A. Roth, R. Komaki, J. Gu, J. J. Lee, M. Hicks, J. Y. Ro, W. K. Hong, J. A. Merritt, K. Ahrar, et al.
Induction of p53-regulated Genes and Tumor Regression in Lung Cancer Patients after Intratumoral Delivery of Adenoviral p53 (INGN 201) and Radiation Therapy
Clin. Cancer Res., January 1, 2003; 9(1): 93 - 101.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. R. Jett, W. J. Scott, M. P. Rivera, and W. T. Sause
Guidelines on Treatment of Stage IIIB Non-small Cell Lung Cancer
Chest, January 1, 2003; 123 (2009): 221S - 225S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. G. Spiro and J. C. Porter
Lung Cancer--Where Are We Today?: Current Advances in Staging and Nonsurgical Treatment
Am. J. Respir. Crit. Care Med., November 1, 2002; 166(9): 1166 - 1196.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
E. E. Vokes, J. E. Herndon II, J. Crawford, K. A. Leopold, M. C. Perry, A. A. Miller, and M. R. Green
Randomized Phase II Study of Cisplatin With Gemcitabine or Paclitaxel or Vinorelbine as Induction Chemotherapy Followed by Concomitant Chemoradiotherapy for Stage IIIB Non-Small-Cell Lung Cancer: Cancer and Leukemia Group B Study 9431
J. Clin. Oncol., October 15, 2002; 20(20): 4191 - 4198.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
K. S. Albain, J. J. Crowley, A. T. Turrisi III, D. R. Gandara, W. B. Farrar, J. I. Clark, K. R. Beasley, and R. B. Livingston
Concurrent Cisplatin, Etoposide, and Chest Radiotherapy in Pathologic Stage IIIB Non-Small-Cell Lung Cancer: A Southwest Oncology Group Phase II Study, SWOG 9019
J. Clin. Oncol., August 15, 2002; 20(16): 3454 - 3460.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
C. Pottgen, W. Eberhardt, S. Bildat, G. Stuben, G. Stamatis, L. Hillejan, S. Sohrab, H. Teschler, S. Seeber, H. Sack, et al.
Induction chemotherapy followed by concurrent chemotherapy and definitive high-dose radiotherapy for patients with locally advanced non-small-cell lung cancer (stages IIIa/IIIb): a pilot phase I/II trial
Ann. Onc., March 1, 2002; 13(3): 403 - 411.
[Abstract] [Full Text] [PDF]

Home page
 DTBHome page
Chemotherapy and non-small-cell lung cancer
DTB, February 1, 2002; 40(2): 9 - 11.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
I. Sekine, Y. Nishiwaki, T. Ogino, A. Yokoyama, M. Saito, K. Mori, I. Tsukiyama, S. Tsuchiya, K. Hayakawa, K. Yoshimura, et al.
Phase II Study of Twice-Daily High-Dose Thoracic Radiotherapy Alternating With Cisplatin and Vindesine for Unresectable Stage III Non-Small-Cell Lung Cancer: Japan Clinical Oncology Group Study 9306
J. Clin. Oncol., February 1, 2002; 20(3): 797 - 803.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
S. Tsuchiya, Y. Ohe, T. Sugiura, N. Fuwa, Y. Kitamoto, K. Mori, H. Kobayashi, K. Nakata, T. Sawa, K. Hirai, et al.
Randomized Phase I Study of Standard-fractionated or Accelerated-hyperfractionated Radiotherapy with Concurrent Cisplatin and Vindesine for Unresectable Non-Small Cell Lung Cancer: a Report of Japan Clinical Oncology Group Study (JCOG 9601)
Jpn. J. Clin. Oncol., October 1, 2001; 31(10): 488 - 494.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
D. H. Grunenwald, F. Andre, C. Le Pechoux, P. Girard, C. Lamer, A. Laplanche, M. Tarayre, R. Arriagada, and T. Le Chevalier
Benefit of surgery after chemoradiotherapy in stage IIIB (T4 and/or N3) non-small cell lung cancer
J. Thorac. Cardiovasc. Surg., October 1, 2001; 122(4): 796 - 802.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
T. L. Evans and T. J. Lynch Jr.
Lung Cancer
Oncologist, October 1, 2001; 6(5): 407 - 414.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
J. S Tobias and D. Ball
Synchronous chemoradiation for squamous carcinomas
BMJ, April 14, 2001; 322(7291): 876 - 878.
[Full Text]

Home page
 JCOHome page
T. J. Robnett, M. Machtay, J. P. Stevenson, K. M. Algazy, and S. M. Hahn
Factors Affecting the Risk of Brain Metastases After Definitive Chemoradiation for Locally Advanced Non-Small-Cell Lung Carcinoma
J. Clin. Oncol., March 1, 2001; 19(5): 1344 - 1349.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. Lau, B. Leigh, D. Gandara, M. Edelman, R. Morgan, V. Israel, P. Lara, R. Wilder, J. Ryu, and J. Doroshow
Twice-Weekly Paclitaxel and Weekly Carboplatin With Concurrent Thoracic Radiation Followed by Carboplatin/Paclitaxel Consolidation for Stage III Non-Small-Cell Lung Cancer: A California Cancer Consortium Phase II Trial
J. Clin. Oncol., January 15, 2001; 19(2): 442 - 447.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. A. Hayman, M. K. Martel, R. K. Ten Haken, D. P. Normolle, R. F. Todd III, J. F. Littles, M. A. Sullivan, P. W. Possert, A. T. Turrisi, and A. S. Lichter
Dose Escalation in Non-Small-Cell Lung Cancer Using Three-Dimensional Conformal Radiation Therapy: Update of a Phase I Trial
J. Clin. Oncol., January 1, 2001; 19(1): 127 - 136.
[Abstract] [Full Text] [PDF]


About
JCO		 Editorial
Roster		 Advertising
Information		 Librarians &
Institutions		 Rights &
Permissions		 PDA Services

Copyright © 1999 by the American Society of Clinical Oncology, Online ISSN: 1527-7755. Print ISSN: 0732-183X
Terms and Conditions of Use
  HighWire Press HighWire Press™ assists in the publication of JCO Online