This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Save to my personal folders Download to citation manager Rights & Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Verschraegen, C. F. Articles by Kavanagh, J. J. Search for Related Content PubMed PubMed Citation Articles by Verschraegen, C. F. Articles by Kavanagh, J. J. Social Bookmarking                            What's this?

Docetaxel for Patients With Paclitaxel-Resistant Müllerian Carcinoma

From the Departments of Internal Medicine Specialties and Biomathematics, University of Texas M.D. Anderson Cancer Center, Houston; M.D. Anderson Outreach, Clear Lake, TX; Department of Obstetrics and Gynecology, Chulalongkorn University, Bangkok, Thailand; and Department of Gynecologic Oncology, Irmandade Santa Casa Misericordia de Porto Alegre Hospital, Porto Alegre, Brazil.

Address reprint requests to Claire F. Verschraegen, MD, Department of Internal Medicine Specialties, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 39, Houston, TX 77030; email cverschr{at}mdanderson.org

PURPOSE: To determine the efficacy and toxicity of docetaxel in patients with müllerian carcinoma resistant to paclitaxel.

PATIENTS AND METHODS: Thirty-two patients with epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer who failed paclitaxel-based chemotherapy received either 100 or 75 mg/m² of docetaxel every 3 weeks. Resistance to paclitaxel was defined as either progression of disease during treatment, failure to achieve regression of disease after at least four courses, or rapid recurrence (within 6 months) after completion of therapy.

RESULTS: Eighteen patients were treated on a formal protocol and fourteen with the commercially available docetaxel. Thirty were assessable for response. Toxicities were thoroughly evaluated in the 18 patients on protocol. Twenty-seven patients (85%) had epithelial ovarian cancer. The overall response rate was 23% (one complete and six partial responses), with a median survival time of 44 weeks (9.5 months). Nine patients had stable disease and 14 progressive disease. Among 19 patients who progressed during prior paclitaxel treatment, two (11%) responded to docetaxel, compared with five (45%) of 11 patients in other paclitaxel-resistance categories. The responders had a median taxane-free interval (ie, the time between the last paclitaxel and first docetaxel treatment) of 73 weeks, compared with 19 weeks for the nonresponder group. Toxic effects were as expected.

CONCLUSION: Docetaxel is an active chemotherapeutic agent in patients with müllerian carcinoma previously treated with paclitaxel-based chemotherapy, especially in the patients who had a long taxane-free interval after a previous short response to paclitaxel.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				H. W Tuffaha, I. M Treish, and L. Zaru The use and effectiveness of granulocyte colony-stimulating factor in primary prophylaxis for febrile neutropenia in the outpatient setting Journal of Oncology Pharmacy Practice, September 1, 2008; 14(3): 131 - 138. [Abstract] [PDF]

				M. Markman New, Expanded, and Modified Use of Approved Antineoplastic Agents in Ovarian Cancer Oncologist, February 1, 2007; 12(2): 186 - 190. [Abstract] [Full Text] [PDF]

				D. Pectasides, E. Pectasides, and T. Economopoulos Fallopian Tube Carcinoma: A Review Oncologist, September 1, 2006; 11(8): 902 - 912. [Abstract] [Full Text] [PDF]

				J. Gligorov and J. P. Lotz Preclinical Pharmacology of the Taxanes: Implications of the Differences Oncologist, June 2, 2004; 9(suppl_2): 3 - 8. [Abstract] [Full Text] [PDF]

				G. J. S. Rustin, R. C. Bast Jr., G. J. Kelloff, J. C. Barrett, S. K. Carter, P. D. Nisen, C. C. Sigman, D. R. Parkinson, and R. W. Ruddon Use of CA-125 in Clinical Trial Evaluation of New Therapeutic Drugs for Ovarian Cancer Clin. Cancer Res., June 1, 2004; 10(11): 3919 - 3926. [Full Text] [PDF]

				G. Aravantinos, D. Bafaloukos, G. Fountzilas, C. Christodoulou, C. Papadimitriou, N. Pavlidis, H. P. Kalofonos, H. Gogas, P. Kosmidis, and M. A. Dimopoulos Phase II study of docetaxel-vinorelbine in platinum-resistant, paclitaxel-pretreated ovarian cancer Ann. Onc., July 1, 2003; 14(7): 1094 - 1099. [Abstract] [Full Text] [PDF]

				P. A. Vasey Role of Docetaxel in the Treatment of Newly Diagnosed Advanced Ovarian Cancer J. Clin. Oncol., May 15, 2003; 21(90100): 136s - 144. [Abstract] [Full Text] [PDF]

				M. Markman, A. Kennedy, K. Webster, G. Peterson, B. Kulp, and J. Belinson Combination Chemotherapy With Carboplatin and Docetaxel in the Treatment of Cancers of the Ovary and Fallopian Tube and Primary Carcinoma of the Peritoneum J. Clin. Oncol., April 1, 2001; 19(7): 1901 - 1905. [Abstract] [Full Text] [PDF]