Journal of Clinical Oncology, Vol 18, Issue 17
(September), 2000: 3135-3143
© 2000 American Society for Clinical Oncology
Rituximab Anti-CD20 Monoclonal Antibody Therapy in Non-Hodgkin’s Lymphoma: Safety and Efficacy of Re-Treatment
By Thomas A. Davis,
Antonio J. Grillo-López,
Christine A. White,
Peter McLaughlin,
Myron S. Czuczman,
Brian K. Link,
David G. Maloney,
Robin L. Weaver,
Jay Rosenberg,
Ronald Levy
From the Stanford University, Stanford; IDEC Pharmaceuticals Corp, San Diego, CA; University of Texas M.D. Anderson Cancer Center, Houston, TX; Roswell Park Cancer Center, Buffalo, NY; University of Iowa, Iowa City, IA; and Fred Hutchinson Cancer Research Center, Seattle, WA.
Address reprint requests to Thomas Davis, MD, EPN715, 6130 Executive Blvd, Rockville, MD 20852; email davist{at}ctep.nci.nih.gov
PURPOSE: This phase II trial investigated the safety and efficacy of re-treatment with rituximab, a chimeric anti-CD20 monoclonal antibody, in patients with low-grade or follicular non-Hodgkin’s lymphoma who relapsed after a response to rituximab therapy.
PATIENTS AND METHODS: Fifty-eight patients were enrolled onto this study, and two were re-treated within the study. Patients received an intravenous infusion of 375 mg/m2 of rituximab weekly for 4 weeks. All patients had at least two prior therapies and had received at least one prior course of rituximab, with a median interval of 14.5 months between rituximab courses.
RESULTS: Most adverse experiences (AEs) were transient grade 1 or 2 events occurring during the treatment period. Clinically significant myelosuppression was not observed; hematologic toxicity was generally mild and reversible. No patient developed human antichimeric antibodies after treatment. The type, frequency, and severity of AEs in this study were not apparently different from those reported in the phase III trial of rituximab. The overall response rate in 57 assessable patients was 40% (11% complete response and 30% partial responses). Median time to progression (TTP) in responders and median duration of response (DR) have not been reached, but Kaplan-Meier estimated medians are 17.8 months (range, 5.4+ to 26.6 months) and 16.3 months (range, 3.7+ to 25.1 months), respectively. These estimated medians are longer than the medians achieved in the patients’ prior course of rituximab (TTP and DR of 12.4 and 9.8 months, respectively, P > .1) and in a previously reported phase III trial (TTP in responders and DR of 13.2 and 11.6 months, respectively). Responses are ongoing in seven of 23 responders.
CONCLUSION: In this re-treatment population, safety and efficacy were not apparently different from those after initial rituximab exposure.
T.A.D. was a Lymphoma Research Foundation Fellow and, subsequently, a Clinical Associate Physician with the General Clinical Research Centers. R.L. is an American Cancer Society Clinical Research Professor.
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A. Quintas-Cardama, W. Wierda, and S. O'Brien
Investigational Immunotherapeutics for B-Cell Malignancies
J. Clin. Oncol.,
February 10, 2010;
28(5):
884 - 892.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Li, S. Huang, X. Wang, D. Zhou, K. Huang, H. Guo, J. Fang, C. Chen, and Q. Liu
Rituximab Combined with Autologous Peripheral Blood Stem Cell Transplantation Improve Therapeutic Effects of Chemotherapy in Pediatric Patients with Burkitt`s Lymphoma
J Trop Pediatr,
January 11, 2010;
(2010)
fmp137v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. de Vos, A. Goy, S. R. Dakhil, M. N. Saleh, P. McLaughlin, R. Belt, C. R. Flowers, M. Knapp, L. Hart, D. Patel-Donnelly, et al.
Multicenter Randomized Phase II Study of Weekly or Twice-Weekly Bortezomib Plus Rituximab in Patients With Relapsed or Refractory Follicular or Marginal-Zone B-Cell Lymphoma
J. Clin. Oncol.,
October 20, 2009;
27(30):
5023 - 5030.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Morschhauser, J. P. Leonard, L. Fayad, B. Coiffier, M.-O. Petillon, M. Coleman, S. J. Schuster, M. J.S. Dyer, H. Horne, N. Teoh, et al.
Humanized Anti-CD20 Antibody, Veltuzumab, in Refractory/Recurrent Non-Hodgkin's Lymphoma: Phase I/II Results
J. Clin. Oncol.,
July 10, 2009;
27(20):
3346 - 3353.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Al-Katib, A. Aboukameel, R. Mohammad, M.-C. Bissery, and C. Zuany-Amorim
Superior Antitumor Activity of SAR3419 to Rituximab in Xenograft Models for Non-Hodgkin's Lymphoma
Clin. Cancer Res.,
June 15, 2009;
15(12):
4038 - 4045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. C. Fervenza
Overcoming Calcineurin Dependence in Membranous Nephropathy: Is Rituximab the Answer?
Clin. J. Am. Soc. Nephrol.,
June 1, 2009;
4(6):
1017 - 1019.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-P. Gerber, M. Kung-Sutherland, I. Stone, C. Morris-Tilden, J. Miyamoto, R. McCormick, S. C. Alley, N. Okeley, B. Hayes, F. J. Hernandez-Ilizaliturri, et al.
Potent antitumor activity of the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE against rituximab-sensitive and -resistant lymphomas
Blood,
April 30, 2009;
113(18):
4352 - 4361.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. D. Crompton, M. Mircetic, G. Weiss, A. Baughman, C.-Y. Huang, D. J. Topham, J. J. Treanor, I. Sanz, F. E.-H. Lee, A. P. Durbin, et al.
The TLR9 Ligand CpG Promotes the Acquisition of Plasmodium falciparum-Specific Memory B Cells in Malaria-Naive Individuals
J. Immunol.,
March 1, 2009;
182(5):
3318 - 3326.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Dalle, S. Dupire, S. Brunet-Manquat, L. Reslan, A. Plesa, and C. Dumontet
In vivo Model of Follicular Lymphoma Resistant to Rituximab
Clin. Cancer Res.,
February 1, 2009;
15(3):
851 - 857.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Goldenberg, E. A. Rossi, R. Stein, T. M. Cardillo, M. S. Czuczman, F. J. Hernandez-Ilizaliturri, H. J. Hansen, and C.-H. Chang
Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody
Blood,
January 29, 2009;
113(5):
1062 - 1070.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Martin, E. Conde, M. Arnan, M. A. Canales, G. Deben, J. M. Sancho, R. Andreu, A. Salar, P. Garcia-Sanchez, L. Vazquez, et al.
R-ESHAP as salvage therapy for patients with relapsed or refractory diffuse large B-cell lymphoma: the influence of prior exposure to rituximab on outcome. A GEL/TAMO study
Haematologica,
December 1, 2008;
93(12):
1829 - 1836.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Racila, B. K. Link, W.-K. Weng, T. E. Witzig, S. Ansell, M. J. Maurer, J. Huang, C. Dahle, A. Halwani, R. Levy, et al.
A Polymorphism in the Complement Component C1qA Correlates with Prolonged Response Following Rituximab Therapy of Follicular Lymphoma
Clin. Cancer Res.,
October 15, 2008;
14(20):
6697 - 6703.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. D. Cheson and J. P. Leonard
Monoclonal Antibody Therapy for B-Cell Non-Hodgkin's Lymphoma
N. Engl. J. Med.,
August 7, 2008;
359(6):
613 - 626.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Luqman, S. Klabunde, K. Lin, G. V. Georgakis, A. Cherukuri, J. Holash, C. Goldbeck, X. Xu, E. E. Kadel III, S. H. Lee, et al.
The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells
Blood,
August 1, 2008;
112(3):
711 - 720.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Chen, C. Su, Q. Lu, W. Shi, Q. Zhang, X. Wang, J. Long, Q. Yang, L. Li, X. Jia, et al.
Generation of adenovirus-mediated anti-CD20 antibody and its effect on B-cell deletion in mice and nonhuman primate cynomolgus monkey
Mol. Cancer Ther.,
June 1, 2008;
7(6):
1562 - 1568.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. C. Fervenza, S. Sethi, and U. Specks
Idiopathic Membranous Nephropathy: Diagnosis and Treatment
Clin. J. Am. Soc. Nephrol.,
May 1, 2008;
3(3):
905 - 919.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. H. Olejniczak, F. J. Hernandez-Ilizaliturri, J. L. Clements, and M. S. Czuczman
Acquired Resistance to Rituximab Is Associated with Chemotherapy Resistance Resulting from Decreased Bax and Bak Expression
Clin. Cancer Res.,
March 1, 2008;
14(5):
1550 - 1560.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Czuczman, S. Olejniczak, A. Gowda, A. Kotowski, A. Binder, H. Kaur, J. Knight, P. Starostik, J. Deans, and F. J. Hernandez-Ilizaliturri
Acquirement of Rituximab Resistance in Lymphoma Cell Lines Is Associated with Both Global CD20 Gene and Protein Down-Regulation Regulated at the Pretranscriptional and Posttranscriptional Levels
Clin. Cancer Res.,
March 1, 2008;
14(5):
1561 - 1570.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. DiLillo, Y. Hamaguchi, Y. Ueda, K. Yang, J. Uchida, K. M. Haas, G. Kelsoe, and T. F. Tedder
Maintenance of Long-Lived Plasma Cells and Serological Memory Despite Mature and Memory B Cell Depletion during CD20 Immunotherapy in Mice
J. Immunol.,
January 1, 2008;
180(1):
361 - 371.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Berentsen
Rituximab for the treatment of autoimmune cytopenias
Haematologica,
December 1, 2007;
92(12):
1589 - 1596.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Daniel, B. Yang, D. A. Lawrence, K. Totpal, I. Balter, W. P. Lee, A. Gogineni, M. J. Cole, S. F. Yee, S. Ross, et al.
Cooperation of the proapoptotic receptor agonist rhApo2L/TRAIL with the CD20 antibody rituximab against non-Hodgkin lymphoma xenografts
Blood,
December 1, 2007;
110(12):
4037 - 4046.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Leonard, B. K. Link, C. Emmanouilides, S. A. Gregory, D. Weisdorf, J. Andrey, J. Hainsworth, J. A. Sparano, D. E. Tsai, S. Horning, et al.
Phase I Trial of Toll-Like Receptor 9 Agonist PF-3512676 with and Following Rituximab in Patients with Recurrent Indolent and Aggressive Non Hodgkin's Lymphoma
Clin. Cancer Res.,
October 15, 2007;
13(20):
6168 - 6174.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Pitini, C. Arrigo, C. Naro, and G. Altavilla
Interleukin-2 and Lymphokine-Activated Killer Cell Therapy in Patients with Relapsed B-Cell Lymphoma Treated with Rituximab
Clin. Cancer Res.,
September 15, 2007;
13(18):
5497 - 5497.
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Martin, R. R. Furman, M. Coleman, and J. P. Leonard
Phase I to III Trials of Anti B Cell Therapy in Non Hodgkin's Lymphoma
Clin. Cancer Res.,
September 15, 2007;
13(18):
5636s - 5642s.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Yanaba, Y. Hamaguchi, G. M. Venturi, D. A. Steeber, E. W. St. Clair, and T. F. Tedder
B Cell Depletion Delays Collagen-Induced Arthritis in Mice: Arthritis Induction Requires Synergy between Humoral and Cell-Mediated Immunity
J. Immunol.,
July 15, 2007;
179(2):
1369 - 1380.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Leonard, J. Friedberg, A Younes, D Fisher, L. Gordon, J Moore, M Czuczman, T Miller, P Stiff, B. Cheson, et al.
A phase I/II study of galiximab (an anti-CD80 monoclonal antibody) in combination with rituximab for relapsed or refractory, follicular lymphoma
Ann. Onc.,
July 1, 2007;
18(7):
1216 - 1223.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A Marinella
Bilateral Conjunctivitis Due to Rituximab
Ann. Pharmacother.,
July 1, 2007;
41(7):
1318 - 1318.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Bello and E. M. Sotomayor
Monoclonal Antibodies for B-Cell Lymphomas: Rituximab and Beyond
Hematology,
January 1, 2007;
2007(1):
233 - 242.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Strauss, F. Morschhauser, J. Rech, R. Repp, P. Solal-Celigny, P. L. Zinzani, A. Engert, B. Coiffier, D. F. Hoelzer, W. A. Wegener, et al.
Multicenter Phase II Trial of Immunotherapy With the Humanized Anti-CD22 Antibody, Epratuzumab, in Combination With Rituximab, in Refractory or Recurrent Non-Hodgkin's Lymphoma
J. Clin. Oncol.,
August 20, 2006;
24(24):
3880 - 3886.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. Sharkey and D. M. Goldenberg
Targeted Therapy of Cancer: New Prospects for Antibodies and Immunoconjugates
CA Cancer J Clin,
July 1, 2006;
56(4):
226 - 243.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Kaminski, J. A. Radford, S. A. Gregory, J. P. Leonard, S. J. Knox, S. Kroll, and R. L. Wahl
Re-Treatment With I-131 Tositumomab in Patients With Non-Hodgkin's Lymphoma Who Had Previously Responded to I-131 Tositumomab
J. Clin. Oncol.,
November 1, 2005;
23(31):
7985 - 7993.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Maloney
Immunotherapy for Non-Hodgkin's Lymphoma: Monoclonal Antibodies and Vaccines
J. Clin. Oncol.,
September 10, 2005;
23(26):
6421 - 6428.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Dunleavy, F. Hakim, H. K. Kim, J. E. Janik, N. Grant, T. Nakayama, T. White, G. Wright, L. Kwak, R. Gress, et al.
B-cell recovery following rituximab-based therapy is associated with perturbations in stromal derived factor-1 and granulocyte homeostasis
Blood,
August 1, 2005;
106(3):
795 - 802.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-T. Tai, X. Li, X. Tong, D. Santos, T. Otsuki, L. Catley, O. Tournilhac, K. Podar, T. Hideshima, R. Schlossman, et al.
Human Anti-CD40 Antagonist Antibody Triggers Significant Antitumor Activity against Human Multiple Myeloma
Cancer Res.,
July 1, 2005;
65(13):
5898 - 5906.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Wojciechowski, H. Li, S. Marshall, C. Dell'Agnola, and I. Espinoza-Delgado
Enhanced Expression of CD20 in Human Tumor B Cells Is Controlled through ERK-Dependent Mechanisms
J. Immunol.,
June 15, 2005;
174(12):
7859 - 7868.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. M. Dhodapkar and M. V. Dhodapkar
Recruiting dendritic cells to improve antibody therapy of cancer
PNAS,
May 3, 2005;
102(18):
6243 - 6244.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. P Levene, G. Singh, and C. Palmieri
Therapeutic monoclonal antibodies in oncology
J R Soc Med,
April 1, 2005;
98(4):
146 - 152.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Hainsworth, S. Litchy, D. W. Shaffer, V. L. Lackey, M. Grimaldi, and F. A. Greco
Maximizing Therapeutic Benefit of Rituximab: Maintenance Therapy Versus Re-Treatment at Progression in Patients With Indolent Non-Hodgkin's Lymphoma--A Randomized Phase II Trial of the Minnie Pearl Cancer Research Network
J. Clin. Oncol.,
February 20, 2005;
23(6):
1088 - 1095.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. N. Gordan, W. B. Grow, A. Pusateri, V. Douglas, N. P. Mendenhall, and J. W. Lynch
Phase II Trial of Individualized Rituximab Dosing for Patients With CD20-Positive Lymphoproliferative Disorders
J. Clin. Oncol.,
February 20, 2005;
23(6):
1096 - 1102.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. E. Witzig, A. M. Vukov, T. M. Habermann, S. Geyer, P. J. Kurtin, W. R. Friedenberg, W. L. White, H. I. Chalchal, P. J. Flynn, T. R. Fitch, et al.
Rituximab Therapy for Patients With Newly Diagnosed, Advanced-Stage, Follicular Grade I Non-Hodgkin's Lymphoma: A Phase II Trial in the North Central Cancer Treatment Group
J. Clin. Oncol.,
February 20, 2005;
23(6):
1103 - 1108.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. L. Monson, P. D. Cravens, E. M. Frohman, K. Hawker, and M. K. Racke
Effect of Rituximab on the Peripheral Blood and Cerebrospinal Fluid B Cells in Patients With Primary Progressive Multiple Sclerosis
Arch Neurol,
February 1, 2005;
62(2):
258 - 264.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. Palomba, W. K. Roberts, T. Dao, G. Manukian, J. A. Guevara-Patino, J. D. Wolchok, D. A. Scheinberg, and A. N. Houghton
CD8+ T-Cell-Dependent Immunity Following Xenogeneic DNA Immunization against CD20 in a Tumor Challenge Model of B-Cell Lymphoma
Clin. Cancer Res.,
January 1, 2005;
11(1):
370 - 379.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ghielmini
Multimodality Therapies and Optimal Schedule of Antibodies: Rituximab in Lymphoma as an Example
Hematology,
January 1, 2005;
2005(1):
321 - 328.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Leonard
Targeting CD20 in Follicular NHL: Novel Anti-CD20 Therapies, Antibody Engineering, and the Use of Radioimmunoconjugates
Hematology,
January 1, 2005;
2005(1):
335 - 339.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. A. Davis, M. S. Kaminski, J. P. Leonard, F. J. Hsu, M. Wilkinson, A. Zelenetz, R. L. Wahl, S. Kroll, M. Coleman, M. Goris, et al.
The Radioisotope Contributes Significantly to the Activity of Radioimmunotherapy
Clin. Cancer Res.,
December 1, 2004;
10(23):
7792 - 7798.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Cartron, H. Watier, J. Golay, and P. Solal-Celigny
From the bench to the bedside: ways to improve rituximab efficacy
Blood,
November 1, 2004;
104(9):
2635 - 2642.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Mikawa, H. Wang, L. Guo, R. Liu, J. Marik, Y. Takada, K. Lam, and D. Lau
Novel peptide ligands for integrin {alpha}4{beta}1 overexpressed in cancer cells
Mol. Cancer Ther.,
October 1, 2004;
3(10):
1329 - 1334.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ghielmini, S.-F. H. Schmitz, S. B. Cogliatti, G. Pichert, J. Hummerjohann, U. Waltzer, M. F. Fey, D. C. Betticher, G. Martinelli, F. Peccatori, et al.
Prolonged treatment with rituximab in patients with follicular lymphoma significantly increases event-free survival and response duration compared with the standard weekly x 4 schedule
Blood,
June 15, 2004;
103(12):
4416 - 4423.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Crombet, M. Osorio, T. Cruz, C. Roca, R. del Castillo, R. Mon, N. Iznaga-Escobar, R. Figueredo, J. Koropatnick, E. Renginfo, et al.
Use of the Humanized Anti-Epidermal Growth Factor Receptor Monoclonal Antibody h-R3 in Combination With Radiotherapy in the Treatment of Locally Advanced Head and Neck Cancer Patients
J. Clin. Oncol.,
May 1, 2004;
22(9):
1646 - 1654.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. L. Gluck, D. Hurst, A. Yuen, A. M. Levine, M. A. Dayton, J. P. Gockerman, J. Lucas, K. Denis-Mize, B. Tong, D. Navis, et al.
Phase I Studies of Interleukin (IL)-2 and Rituximab in B-Cell Non-Hodgkin's Lymphoma: IL-2 Mediated Natural Killer Cell Expansion Correlations with Clinical Response
Clin. Cancer Res.,
April 1, 2004;
10(7):
2253 - 2264.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Jermann, L. M. Jost, Ch. Taverna, E. Jacky, H. P. Honegger, D. C. Betticher, F. Egli, Th. Kroner, and R. A. Stahel
Rituximab-EPOCH, an effective salvage therapy for relapsed, refractory or transformed B-cell lymphomas: results of a phase II study
Ann. Onc.,
March 1, 2004;
15(3):
511 - 516.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Pless, K. Belhadj, H. D. Menssen, W. Kern, B. Coiffier, J. Wolf, R. Herrmann, E. Thiel, D. Bootle, I. Sklenar, et al.
Clinical Efficacy, Tolerability, and Safety of SAM486A, a Novel Polyamine Biosynthesis Inhibitor, in Patients with Relapsed or Refractory Non-Hodgkin's Lymphoma: Results from a Phase II Multicenter Study
Clin. Cancer Res.,
February 15, 2004;
10(4):
1299 - 1305.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. J. Hernandez-Ilizaliturri, V. Jupudy, J. Ostberg, E. Oflazoglu, A. Huberman, E. Repasky, and M. S. Czuczman
Neutrophils Contribute to the Biological Antitumor Activity of Rituximab in a Non-Hodgkin's Lymphoma Severe Combined Immunodeficiency Mouse Model
Clin. Cancer Res.,
December 1, 2003;
9(16):
5866 - 5873.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Jilani, S. O'Brien, T. Manshuri, D. A. Thomas, V. A. Thomazy, M. Imam, S. Naeem, S. Verstovsek, H. Kantarjian, F. Giles, et al.
Transient down-modulation of CD20 by rituximab in patients with chronic lymphocytic leukemia
Blood,
November 15, 2003;
102(10):
3514 - 3520.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Andreone, A. Gramenzi, S. Lorenzini, M. Biselli, C. Cursaro, S. Pileri, and M. Bernardi
Posttransplantation Lymphoproliferative Disorders
Arch Intern Med,
September 22, 2003;
163(17):
1997 - 2004.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Ruggenenti, C. Chiurchiu, V. Brusegan, M. Abbate, A. Perna, C. Filippi, and G. Remuzzi
Rituximab in Idiopathic Membranous Nephropathy: A One-Year Prospective Study
J. Am. Soc. Nephrol.,
July 1, 2003;
14(7):
1851 - 1857.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Mangel, R. Buckstein, K. Imrie, D. Spaner, E. Franssen, P. Pavlin, A. Boudreau, N. Pennell, D. Combs, and N. L. Berinstein
Pharmacokinetic study of patients with follicular or mantle cell lymphoma treated with rituximab as 'in vivo purge' and consolidative immunotherapy following autologous stem cell transplantation
Ann. Onc.,
May 1, 2003;
14(5):
758 - 765.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Boye, T. Elter, and A. Engert
An overview of the current clinical use of the anti-CD20 monoclonal antibody rituximab
Ann. Onc.,
April 1, 2003;
14(4):
520 - 535.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. O. Armitage, P. P. Carbone, J. M. Connors, A. Levine, J. M. Bennett, and S. Kroll
Treatment-Related Myelodysplasia and Acute Leukemia in Non-Hodgkin's Lymphoma Patients
J. Clin. Oncol.,
March 1, 2003;
21(5):
897 - 906.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Rehwald, H. Schulz, M. Reiser, M. Sieber, J. O. Staak, F. Morschhauser, C. Driessen, T. Rudiger, K. Muller-Hermelink, V. Diehl, et al.
Treatment of relapsed CD20+ Hodgkin lymphoma with the monoclonal antibody rituximab is effective and well tolerated: results of a phase 2 trial of the German Hodgkin Lymphoma Study Group
Blood,
January 15, 2003;
101(2):
420 - 424.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Hainsworth, S. Litchy, H. A. Burris III, D. C. Scullin Jr, S. W. Corso, D. A. Yardley, L. Morrissey, and F. A. Greco
Rituximab as First-Line and Maintenance Therapy for Patients With Indolent Non-Hodgkin's Lymphoma
J. Clin. Oncol.,
October 15, 2002;
20(20):
4261 - 4267.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Ben-Bassat, Z. Hartzstark, R. Levitzki, B. Y. Klein, Z. Shlomai, A. Gazit, and A. Levitzki
Tyrosine Kinase Inhibitors Suppress the Growth of Non-Hodgkin B Lymphomas
J. Pharmacol. Exp. Ther.,
October 1, 2002;
303(1):
163 - 171.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. E. Witzig, I. W. Flinn, L. I. Gordon, C. Emmanouilides, M. S. Czuczman, M. N. Saleh, L. Cripe, G. Wiseman, T. Olejnik, P. S. Multani, et al.
Treatment With Ibritumomab Tiuxetan Radioimmunotherapy in Patients With Rituximab-Refractory Follicular Non-Hodgkin's Lymphoma
J. Clin. Oncol.,
August 1, 2002;
20(15):
3262 - 3269.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Rambaldi, M. Lazzari, C. Manzoni, E. Carlotti, L. Arcaini, M. Baccarani, T. Barbui, C. Bernasconi, G. Dastoli, G. Fuga, et al.
Monitoring of minimal residual disease after CHOP and rituximab in previously untreated patients with follicular lymphoma
Blood,
February 1, 2002;
99(3):
856 - 862.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Harig, M. Witzens, A. M. Krackhardt, A. Trojan, P. Barrett, R. Broderick, A. J. Zauls, and J. G. Gribben
Induction of cytotoxic T-cell responses against immunoglobulin V region-derived peptides modified at human leukocyte antigen-A2 binding residues
Blood,
November 15, 2001;
98(10):
2999 - 3005.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. D. Cheson
Some Like It Hot!
J. Clin. Oncol.,
October 1, 2001;
19(19):
3908 - 3911.
[Full Text]
|
|
|
|
|
|
|
O. W. Press, J. P. Leonard, B. Coiffier, R. Levy, and J. Timmerman
Immunotherapy of Non-Hodgkin's Lymphomas
Hematology,
January 1, 2001;
2001(1):
221 - 240.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Hainsworth
Monoclonal Antibody Therapy in Lymphoid Malignancies
Oncologist,
October 1, 2000;
5(5):
376 - 384.
[Abstract]
[Full Text]
|
|
|
|
