Journal of Clinical Oncology, Vol 18, Issue 4
(February), 2000: 893
© 2000 American Society for Clinical Oncology
Depression in Patients With Lung Cancer: Prevalence and Risk Factors Derived From Quality-of-Life Data
By Penelope Hopwood,
Richard J. Stephens,
for the British Medical Research Council Lung Cancer Working Party
From The Cancer Research Campaign Psychological Medicine Group, Christie Hospital National Health Service Trust, Withington, Manchester; Cancer Division, Medical Research Council Clinical Trials Unit, London, United Kingdom.
Address reprint requests to P. Hopwood, MD, Cancer Research Campaign Psychological Medicine Group, Stanley House, Christie Hospital NHS Trust, Withington, Manchester, M20 4BX, UK; email penelope.hopwood@ man.ac.uk.
PURPOSE: To evaluate self-reported depression rates in patients with inoperable lung cancer and to explore demographic, clinical, and quality-of-life (QOL) factors associated with depression and thus identify patients at risk.
PATIENTS AND METHODS: Nine hundred eighty-seven patients from three palliative treatment trials conducted by the Medical Research Council Lung Cancer Working Party formed the study sample. 526 patients (53%) had poor prognosis small-cell lung cancer (SCLC) and 461 patients (47%) had good prognosis non–small-cell lung cancer (NSCLC). Hospital Anxiety and Depression Scale data and QOL items from the Rotterdam Symptom Checklist were analyzed, together with relevant demographic and clinical factors.
RESULTS: Depression was self-rated in 322 patients (33%) before treatment and persisted in more than 50% of patients. SCLC patients had a three-fold greater prevalence of case depression than those with NSCLC (25% v 9%; P < .0001). An increased rate for women was found for good performance status (PS) patients (PS of 0 or 1) but the sex difference reduced for poor PS patients (PS of 3 or 4) because of increased depression rates for men ( 2 for trend, P < .0001). Multivariate analysis showed that functional impairment was the most important risk factor; depression increased by 41% for each increment on the impairment scale. Pretreatment physical symptom burden, fatigue, and clinician-rated PS were also independent predictors, but cell type was not.
CONCLUSION: Depression is common and persistent in lung cancer patients, especially those with more severe symptoms or functional limitations. Psychologic screening and appropriate intervention is an essential part of palliative care.
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Facebook  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Olden, B. Rosenfeld, H. Pessin, and W. Breitbart
Measuring Depression at the End of Life: Is the Hamilton Depression Rating Scale a Valid Instrument?
Assessment,
March 1, 2009;
16(1):
43 - 54.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. Sarna, M. E. Cooley, J. K. Brown, C. Chernecky, D. Elashoff, and J. Kotlerman
Symptom Severity 1 to 4 Months After Thoracotomy for Lung Cancer
Am. J. Crit. Care.,
September 1, 2008;
17(5):
455 - 467.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. F. Pirl, J. S. Temel, A. Billings, C. Dahlin, V. Jackson,, H. G. Prigerson, J. Greer, and T. J. Lynch
Depression After Diagnosis of Advanced Non-Small Cell Lung Cancer and Survival: A Pilot Study
Psychosomatics,
May 1, 2008;
49(3):
218 - 224.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Kvale, P. A. Selecky, and U. B. S. Prakash
Palliative Care in Lung Cancer: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition)
Chest,
September 1, 2007;
132(3_suppl):
368S - 403S.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Griffin, K. A. Koch, J. E. Nelson, and M. E. Cooley
Palliative Care Consultation, Quality-of-Life Measurements, and Bereavement for End-of-Life Care in Patients With Lung Cancer: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition)
Chest,
September 1, 2007;
132(3_suppl):
404S - 422S.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gripp, S. Moeller, E. Bolke, G. Schmitt, C. Matuschek, S. Asgari, F. Asgharzadeh, S. Roth, W. Budach, M. Franz, et al.
Survival Prediction in Terminally Ill Cancer Patients by Clinical Estimates, Laboratory Tests, and Self-Rated Anxiety and Depression
J. Clin. Oncol.,
August 1, 2007;
25(22):
3313 - 3320.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Temel, V. A. Jackson, J. A. Billings, C. Dahlin, S. D. Block, M. K. Buss, P. Ostler, P. Fidias, A. Muzikansky, J. A. Greer, et al.
Phase II Study: Integrated Palliative Care in Newly Diagnosed Advanced Non-Small-Cell Lung Cancer Patients
J. Clin. Oncol.,
June 10, 2007;
25(17):
2377 - 2382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Skaug, G. E. Eide, and A. Gulsvik
Prevalence and Predictors of Symptoms in the Terminal Stage of Lung Cancer: A Community Study
Chest,
February 1, 2007;
131(2):
389 - 394.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Lobo, P. De Jonge, F. J. Huyse, J. P.J. Slaets, M.-J. Rabanaque, and A. Lobo
Early Detection of Pneumology Inpatients at Risk of Extended Hospital Stay and Need for Psychosocial Treatment
Psychosom Med,
January 1, 2007;
69(1):
99 - 105.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Thorsen, E. Skovlund, S. B. Stromme, K. Hornslien, A. A. Dahl, and S. D. Fossa
Effectiveness of Physical Activity on Cardiorespiratory Fitness and Health-Related Quality of Life in Young and Middle-Aged Cancer Patients Shortly After Chemotherapy
J. Clin. Oncol.,
April 1, 2005;
23(10):
2378 - 2388.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. C. Earle
Outcomes Research in Lung Cancer
J Natl Cancer Inst Monographs,
October 1, 2004;
2004(33):
56 - 77.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. G. Walker
Integrative Tumor Board: Recurrent Lymphoma
Integr Cancer Ther,
September 1, 2004;
3(3):
250 - 254.
[PDF]
|
|
|
|
|
|
|
M. Lloyd-Williams, M. Dennis, and F. Taylor
A prospective study to determine the association between physical symptoms and depression in patients with advanced cancer
Palliative Medicine,
September 1, 2004;
18(6):
558 - 563.
[Abstract]
[PDF]
|
|
|
|
|
|
|
W. F. Pirl
Evidence Report on the Occurrence, Assessment, and Treatment of Depression in Cancer Patients
J Natl Cancer Inst Monographs,
July 1, 2004;
2004(32):
32 - 39.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Massie
Prevalence of Depression in Patients With Cancer
J Natl Cancer Inst Monographs,
July 1, 2004;
2004(32):
57 - 71.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Miaskowski
Gender Differences in Pain, Fatigue, and Depression in Patients With Cancer
J Natl Cancer Inst Monographs,
July 1, 2004;
2004(32):
139 - 143.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Smith, S. Gomm, and C. Dickens
Assessing the independent contribution to quality of life from anxiety and depression in patients with advanced cancer
Palliative Medicine,
September 1, 2003;
17(6):
509 - 513.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K. W. Brown, A. R. Levy, Z. Rosberger, and L. Edgar
Psychological Distress and Cancer Survival: A Follow-Up 10 Years After Diagnosis
Psychosom Med,
July 1, 2003;
65(4):
636 - 643.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Lloyd-Williams, J. Spiller, and J. Ward
Which depression screening tools should be used in palliative care?
Palliative Medicine,
January 1, 2003;
17(1):
40 - 43.
[Abstract]
[PDF]
|
|
|
|
|
|
|
Y. Uchitomi, I. Mikami, K. Nagai, Y. Nishiwaki, T. Akechi, and H. Okamura
Depression and Psychological Distress in Patients During the Year After Curative Resection of Non-Small-Cell Lung Cancer
J. Clin. Oncol.,
January 1, 2003;
21(1):
69 - 77.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Moore, J. Corner, J. Haviland, M. Wells, E. Salmon, C. Normand, M. Brada, M. O'Brien, and I. Smith
Nurse led follow up and conventional medical follow up in management of patients with lung cancer: randomised trial
BMJ,
November 16, 2002;
325(7373):
1145 - 1145.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Stark, M. Kiely, A. Smith, G. Velikova, A. House, and P. Selby
Anxiety Disorders in Cancer Patients: Their Nature, Associations, and Relation to Quality of Life
J. Clin. Oncol.,
July 15, 2002;
20(14):
3137 - 3148.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Sarna, G. Padilla, C. Holmes, D. Tashkin, M. L. Brecht, and L. Evangelista
Quality of Life of Long-Term Survivors of Non-Small-Cell Lung Cancer
J. Clin. Oncol.,
July 1, 2002;
20(13):
2920 - 2929.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Holzner, G. Kemmler, R. Greil, M. Kopp, A. Zeimet, M. Raderer, M. Hejna, S. Zochbauer, G. Krajnik, H. Huber, et al.
The impact of hemoglobin levels on fatigue and quality of life in cancer patients
Ann. Onc.,
June 1, 2002;
13(6):
965 - 973.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Prieto, J. Blanch, J. Atala, E. Carreras, M. Rovira, E. Cirera, and C. Gasto
Psychiatric Morbidity and Impact on Hospital Length of Stay Among Hematologic Cancer Patients Receiving Stem-Cell Transplantation
J. Clin. Oncol.,
April 1, 2002;
20(7):
1907 - 1917.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
