This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Save to my personal folders Download to citation manager Rights & Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mendenhall, W. M. Articles by Hinerman, R. W. Search for Related Content PubMed PubMed Citation Articles by Mendenhall, W. M. Articles by Hinerman, R. W. Social Bookmarking                            What's this?

T1-T2N0 Squamous Cell Carcinoma of the Glottic Larynx Treated With Radiation Therapy

From the Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL.

Address correspondence to William M. Mendenhall, MD, Department of Radiation Oncology, PO Box 100385, Gainesville, FL 32610-0385; email: mendewil{at}shands.ufl.edu

PURPOSE: The end results after radiation therapy for T1-T2N0 glottic carcinoma vary considerably. We analyze patient-related and treatment-related parameters that may influence the likelihood of cure.

PATIENTS AND METHODS: Five hundred nineteen patients were treated with radiation therapy and had follow-up for 2 years. Three patients who were disease-free were lost to follow-up at 7 months, 21 months, and 10.5 years. No other patients were lost to follow-up.

RESULTS: Local control rates at 5 years after radiation therapy were as follows: T1A, 94%; T1B, 93%; T2A, 80%; and T2B, 72%. Multivariate analysis of local control revealed that the following parameters significantly influenced this end point: overall treatment time (P < .0001), T stage (P = .0003), and histologic differentiation (P = .013). Patients with poorly differentiated cancers fared less well than those with better differentiated lesions. Rates of local control with laryngeal preservation at 5 years were as follows: T1A and T1B, 95%; T2A, 82%; and T2B, 76%. Cause-specific survival rates at 5 years were as follows: T1A and T1B, 98%; T2A, 95%; and T2B, 90%. One patient with a T1N0 cancer and three patients with T2N0 lesions experienced severe late radiation complications.

CONCLUSION: Radiation therapy cures a high percentage of patients with T1-T2N0 glottic carcinomas and has a low rate of severe complications. The major treatment-related parameter that influences the likelihood of cure is overall treatment time.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				E. D. McCoul and G. Har-El Meta-analysis of Impaired Vocal Cord Mobility as a Prognostic Factor in T2 Glottic Carcinoma Arch Otolaryngol Head Neck Surg, May 1, 2009; 135(5): 479 - 486. [Abstract] [Full Text] [PDF]

				G. NISHIMURA, M. TSUKUDA, Y. MIKAMI, H. MATSUDA, C. HORIUCHI, T. TAGUCHI, M. TAKAHASHI, M. KAWAKAMI, M. WATANABE, T. NIHO, et al. Efficacy of Concurrent Chemoradiotherapy for T1 and T2 Laryngeal Squamous Cell Carcinoma Regarding Organ Preservation Anticancer Res, February 1, 2009; 29(2): 661 - 666. [Abstract] [Full Text] [PDF]

				M. K. Sackett, I. Bairati, F. Meyer, E. Jobin, S. Lussier, A. Fortin, M. Gelinas, A. Nabid, F. Brochet, and B. Tetu Prognostic Significance of Cyclooxygenase-2 Overexpression in Glottic Cancer Clin. Cancer Res., January 1, 2008; 14(1): 67 - 73. [Abstract] [Full Text] [PDF]

				D. G. Pfister, S. A. Laurie, G. S. Weinstein, W. M. Mendenhall, D. J. Adelstein, K. K. Ang, G. L. Clayman, S. G. Fisher, A. A. Forastiere, L. B. Harrison, et al. American Society of Clinical Oncology Clinical Practice Guideline for the Use of Larynx-Preservation Strategies in the Treatment of Laryngeal Cancer J. Clin. Oncol., August 1, 2006; 24(22): 3693 - 3704. [Abstract] [Full Text] [PDF]

				S. A. Pradhan, P. S. Pai, S. I. Neeli, and A. K. D'Cruz Transoral Laser Surgery for Early Glottic Cancers Arch Otolaryngol Head Neck Surg, June 1, 2003; 129(6): 623 - 625. [Abstract] [Full Text] [PDF]