Advertisement
Journal of Clinical Oncology  
Search for:
Limit by:
  Browse by Subject or Issue
Home Search or Browse JCO My JCO Subscriptions Customer Service Site Map

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Save to my personal folders
Right arrow Download to citation manager
Right arrowRights & Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ma, J.
Right arrow Articles by Mo, H.-Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ma, J.
Right arrow Articles by Mo, H.-Y.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
Journal of Clinical Oncology, Vol 19, Issue 5 (March), 2001: 1350-1357
© 2001 American Society for Clinical Oncology

Results of a Prospective Randomized Trial Comparing Neoadjuvant Chemotherapy Plus Radiotherapy With Radiotherapy Alone in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma

By Jun Ma, Hai-Qiang Mai, Ming-Huang Hong, Hua-Qing Min, Zhi-Da Mao, Nian-Ji Cui, Tai-Xiang Lu, Hao-Yuan Mo

From the Departments of Nasopharyngeal Carcinoma and Radiation Oncology, Cancer Center, Sun Yat-sen University of Medical Sciences, Guangzhou, People’s Republic of China.

Address reprint requests to Jun Ma, MD, Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat-sen University of Medical Sciences, 651 Dongfeng Road East, Guangzhou 510060, People’s Republic of China; email: Dr.MaJun{at}163.net

PURPOSE: A prospective randomized trial was performed to evaluate the contribution of neoadjuvant chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma.

PATIENTS AND METHODS: Patients with locoregionally advanced nasopharyngeal carcinoma were treated either with radiotherapy alone (RT group) or neoadjuvant chemotherapy plus radiotherapy (CT/RT group). Neoadjuvant chemotherapy consisting of two to three cycles of cisplatin (100 mg/m2, day 1), bleomycin (10 mg/m2, days 1 and 5), and fluorouracil (5-FU; 800 mg/m2, days 1 through 5, continuous infusion) followed by radiotherapy was given to the CT/RT group. All patients were treated in a uniform fashion by definitive-intent radiation therapy in both groups.

RESULTS: Between July 1993 and July 1994, 456 patients were entered onto the study, with 228 patients randomized to each treatment arm, and 449 patients (225 in the RT group and 224 in the CT/RT group) were assessable. All 456 patients were included in survival analysis according to the intent-to-treat principle. The 5-year overall survival (OS) rates were 63% for the CT/RT group and 56% for the RT group (P = .11). The median relapse-free survival (RFS) time was 50 months for the RT group and not reached for the CT/RT group. The 5-year RFS rate was 49% for the RT group versus 59% for the CT/RT group (P = .05). The 5-year freedom from local recurrence rate was 82% for the CT/RT group and 74% for the RT group (P = .04). There was no significant difference in freedom from distant metastasis between the two treatment groups (CT/RT group, 79%; RT group, 75%; P = .40).

CONCLUSION: This randomized study failed to demonstrate any significant survival benefit with the addition of neoadjuvant chemotherapy for patients with locoregionally advanced nasopharyngeal carcinoma. Therefore, neoadjuvant chemotherapy for nasopharyngeal carcinoma should not be used outside of the context of a clinical trial.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JCOHome page
E. P. Hui, B. B. Ma, S. F. Leung, A. D. King, F. Mo, M. K. Kam, B. K. Yu, S. K. Chiu, W. H. Kwan, R. Ho, et al.
Randomized Phase II Trial of Concurrent Cisplatin-Radiotherapy With or Without Neoadjuvant Docetaxel and Cisplatin in Advanced Nasopharyngeal Carcinoma
J. Clin. Oncol., January 10, 2009; 27(2): 242 - 249.
[Abstract] [Full Text] [PDF]

Home page
 Arch Otolaryngol Head Neck SurgHome page
A. C. Vlantis, R. K. Y. Tsang, B. K. H. Yu, M. K. M. Kam, M. C. F. Tong, P. S. Y. Lo, and C. Andrew van Hasselt
Nasopharyngectomy and Surgical Margin Status: A Survival Analysis
Arch Otolaryngol Head Neck Surg, December 1, 2007; 133(12): 1296 - 1301.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R. Glynne-Jones and P. Hoskin
Neoadjuvant Cisplatin Chemotherapy Before Chemoradiation: A Flawed Paradigm?
J. Clin. Oncol., November 20, 2007; 25(33): 5281 - 5286.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W.-T. Liao, L.-B. Song, H.-Z. Zhang, X. Zhang, L. Zhang, W.-L. Liu, Y. Feng, B.-H. Guo, H.-Q. Mai, S.-M. Cao, et al.
Centromere Protein H Is a Novel Prognostic Marker for Nasopharyngeal Carcinoma Progression and Overall Patient Survival
Clin. Cancer Res., January 15, 2007; 13(2): 508 - 514.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
A. S. C. Wong, R. A. Soo, J. J. Lu, K. S. Loh, K. S. Tan, W. S. Hsieh, T. P. Shakespeare, E. T. Chua, H. L. Lim, and B. C. Goh
Paclitaxel, 5-fluorouracil and hydroxyurea concurrent with radiation in locally advanced nasopharyngeal carcinoma
Ann. Onc., July 1, 2006; 17(7): 1152 - 1157.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
L. Zhang, C. Zhao, P.-J. Peng, L.-X. Lu, P.-Y. Huang, F. Han, and S.-X. Wu
Phase III Study Comparing Standard Radiotherapy With or Without Weekly Oxaliplatin in Treatment of Locoregionally Advanced Nasopharyngeal Carcinoma: Preliminary Results
J. Clin. Oncol., November 20, 2005; 23(33): 8461 - 8468.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. Wee, E. H. Tan, B. C. Tai, H. B. Wong, S. S. Leong, T. Tan, E. T. Chua, E. Yang, K. M. Lee, K. W. Fong, et al.
Randomized Trial of Radiotherapy Versus Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy in Patients With American Joint Committee on Cancer/International Union Against Cancer Stage III and IV Nasopharyngeal Cancer of the Endemic Variety
J. Clin. Oncol., September 20, 2005; 23(27): 6730 - 6738.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. H. Cheng and A. T. Huang
Comments on Concurrent and Adjuvant Chemotherapy for Nasopharyngeal Carcinoma: A Mist of Mysterious Results
J. Clin. Oncol., April 20, 2005; 23(12): 2864 - 2865.
[Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. T. C. Chan, S. F. Leung, R. K. C. Ngan, P. M. L. Teo, W. H. Lau, W. H. Kwan, E. P. Hui, H. Y. Yiu, W. Yeo, F. Y. Cheung, et al.
Overall Survival After Concurrent Cisplatin-Radiotherapy Compared With Radiotherapy Alone in Locoregionally Advanced Nasopharyngeal Carcinoma
J Natl Cancer Inst, April 6, 2005; 97(7): 536 - 539.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
K. Isobe, T. Uno, H. Kawakami, N. Ueno, T. Aruga, S. Yasuda, T. Hanazawa, Y. Okamoto, H. Ito, and N. Shigematsu
Hyperfractionated Radiation Therapy for Locoregionally Advanced Nasopharyngeal Cancer
Jpn. J. Clin. Oncol., March 1, 2005; 35(3): 116 - 120.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. T.T. Chua, J. Ma, J. S.T. Sham, H.-Q. Mai, D. T.K. Choy, M.-H. Hong, T.-X. Lu, and H.-Q. Min
Long-Term Survival After Cisplatin-Based Induction Chemotherapy and Radiotherapy for Nasopharyngeal Carcinoma: A Pooled Data Analysis of Two Phase III Trials
J. Clin. Oncol., February 20, 2005; 23(6): 1118 - 1124.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J.A. Langendijk, Ch.R. Leemans, J. Buter, J. Berkhof, and B.J. Slotman
The Additional Value of Chemotherapy to Radiotherapy in Locally Advanced Nasopharyngeal Carcinoma: A Meta-Analysis of the Published Literature
J. Clin. Oncol., November 15, 2004; 22(22): 4604 - 4612.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
M. Kawashima, N. Fuwa, M. Myojin, K. Nakamura, T. Toita, S. Saijo, N. Hayashi, H. Ohnishi, N. Shikama, M. Kano, et al.
A Multi-institutional Survey of the Effectiveness of Chemotherapy Combined with Radiotherapy for Patients with Nasopharyngeal Carcinoma
Jpn. J. Clin. Oncol., October 1, 2004; 34(10): 569 - 583.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. T.C. Chan, B. B.Y. Ma, Y.M. D. Lo, S.F. Leung, W.H. Kwan, E. P. Hui, T. S.K. Mok, M. Kam, L. S. Chan, S. K.W. Chiu, et al.
Phase II Study of Neoadjuvant Carboplatin and Paclitaxel Followed by Radiotherapy and Concurrent Cisplatin in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma: Therapeutic Monitoring With Plasma Epstein-Barr Virus DNA
J. Clin. Oncol., August 1, 2004; 22(15): 3053 - 3060.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
L. Licitra and J. B. Vermorken
Is there still a role for neoadjuvant chemotherapy in head and neck cancer?
Ann. Onc., January 1, 2004; 15(1): 7 - 11.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
K. Isobe, H. Kawakami, T. Uno, S. Yasuda, T. Aruga, N. Ueno, T. Kawata, and H. Ito
Concurrent Chemoradiotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma: is Intergroup Study 0099 Feasible in Japanese Patients?
Jpn. J. Clin. Oncol., October 1, 2003; 33(10): 497 - 500.
[Abstract] [Full Text] [PDF]

Home page
 Arch Otolaryngol Head Neck SurgHome page
T. P. Farias, F. L. Dias, R. A. Lima, J. Kligerman, G. M. de Sa, M. M. Barbosa, and F. B. Goncalves Jr
Prognostic Factors and Outcome for Nasopharyngeal Carcinoma
Arch Otolaryngol Head Neck Surg, July 1, 2003; 129(7): 794 - 799.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
J. L. Oh, E. E. Vokes, M. S. Kies, B. B. Mittal, M. E. Witt, R. R. Weichselbaum, and D. J. Haraf
Induction chemotherapy followed by concomitant chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal cancer
Ann. Onc., April 1, 2003; 14(4): 564 - 569.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J.-C. Lin, J.-S. Jan, C.-Y. Hsu, W.-M. Liang, R.-S. Jiang, and W.-Y. Wang
Phase III Study of Concurrent Chemoradiotherapy Versus Radiotherapy Alone for Advanced Nasopharyngeal Carcinoma: Positive Effect on Overall and Progression-Free Survival
J. Clin. Oncol., February 15, 2003; 21(4): 631 - 637.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. T. C. Chan, Y. M. D. Lo, B. Zee, L. Y. S. Chan, B. B. Y. Ma, S.-F. Leung, F. Mo, M. Lai, S. Ho, D. P. Huang, et al.
Plasma Epstein-Barr Virus DNA and Residual Disease After Radiotherapy for Undifferentiated Nasopharyngeal Carcinoma
J Natl Cancer Inst, November 6, 2002; 94(21): 1614 - 1619.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
A. T. C. Chan, P. M. L. Teo, and P. J. Johnson
Nasopharyngeal carcinoma
Ann. Onc., July 1, 2002; 13(7): 1007 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. Rischin and L. J. Peters
The Local-Regionally Advanced Nasopharyngeal Carcinoma Jigsaw Puzzle: Where Does the Chemotherapy Piece Fit?
J. Clin. Oncol., April 15, 2002; 20(8): 1968 - 1970.
[Full Text] [PDF]

Home page
 JCOHome page
D. Rischin, J. Corry, J. Smith, J. Stewart, P. Hughes, and L. Peters
Excellent Disease Control and Survival in Patients With Advanced Nasopharyngeal Cancer Treated With Chemoradiation
J. Clin. Oncol., April 1, 2002; 20(7): 1845 - 1852.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
R F Mould and T H P Tai
Nasopharyngeal carcinoma: treatments and outcomes in the 20th century
Br. J. Radiol., April 1, 2002; 75(892): 307 - 339.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
L-M Sun, T-Y Chen, W-J Chen, M-J Hsieh, J-W Liu, C-C Huang, and C-J Wang
Cryptococcus infection in a patient with nasopharyngeal carcinoma: imaging findings mimicking pulmonary metastases
Br. J. Radiol., March 1, 2002; 75(891): 275 - 278.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R.-L. Hong, L.-L. Ting, J.-Y. Ko, M.-M. Hsu, T.-S. Sheen, P.-J. Lou, C.-C. Wang, N.-N. Chung, and L. T. Lui
Induction Chemotherapy With Mitomycin, Epirubicin, Cisplatin, Fluorouracil, and Leucovorin Followed by Radiotherapy in the Treatment of Locoregionally Advanced Nasopharyngeal Carcinoma
J. Clin. Oncol., December 1, 2001; 19(23): 4305 - 4313.
[Abstract] [Full Text]


About
JCO		 Editorial
Roster		 Advertising
Information		 Librarians &
Institutions		 Rights &
Permissions		 PDA Services

Copyright © 2001 by the American Society of Clinical Oncology, Online ISSN: 1527-7755. Print ISSN: 0732-183X
Terms and Conditions of Use
  HighWire Press HighWire Press™ assists in the publication of JCO Online