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Journal of Clinical Oncology, Vol 20, Issue 21 (November), 2002: 4285-4291
© 2002 American Society for Clinical Oncology

Phase III Randomized Trial Comparing Three Platinum-Based Doublets in Advanced Non–Small-Cell Lung Cancer

By G.V. Scagliotti, F. De Marinis, M. Rinaldi, L. Crinò, C. Gridelli, S. Ricci, E. Matano, C. Boni, M. Marangolo, G. Failla, G. Altavilla, V. Adamo, A. Ceribelli, M. Clerici, F. Di Costanzo, L. Frontini, M. Tonato for the Italian Lung Cancer Project

From the Department of Clinical and Biological Sciences, University of Torino, Turin; Division of Pneumo-Oncology V, C. Forlanini Hospital, Division of Medical Oncology B, Regina Elena Institute, and Division of Medical Oncology A, Regina Elena Institute, Rome; Division of Medical Oncology, Bellaria Hospital, Bologna; Division of Medical Oncology B, National Cancer Institute "G. Pascale" and Department of Endocrinology and Molecular and Clinical Oncology, Federico II University, Naples; Division of Medical Oncology, S. Chiara Hospital, Pisa; Division of Medical Oncology, S. Maria Hospital, Reggio Emilia; Division of Medical Oncology, S. Maria delle Croci Hospital, Ravenna; Division of Medical Oncology, S. Luigi and S. Curro Hospital, Catania; Department of Medical Oncology, University of Messina, Messina; Division of Medical Oncology, S. Giuseppe Hospital and Division of Medical Oncology, L. Sacco Hospital, Milan; Division of Medical Oncology, S. Maria Hospital, Terni; and Division of Medical Oncology, Policlinico Hospital, Perugia, Italy.

Address reprint requests to Giorgio V. Scagliotti, MD, University of Turin, Department of Clinical and Biological Sciences, Azienda Ospedaliera S Luigi, Regione Gonzole 10, 10043 Orbassano, Torino, Italy; email: scagliotti{at}ihnet.it

PURPOSE: To evaluate whether two commonly used newer platinum-based regimens offer any advantage over vinorelbine-cisplatin (reference regimen) in response rate for patients with advanced non–small-cell lung cancer (NSCLC).

PATIENTS AND METHODS: Chemotherapy-naive patients were randomized to receive gemcitabine 1,250 mg/m2 days 1 and 8 plus cisplatin 75 mg/m2 day 2 every 21 days (GC arm), or paclitaxel 225 mg/m2 (3-hour infusion) then carboplatin (area under the concentration-time curve of 6 mg/mL·min), both on day 1 every 21 days (PCb arm), or vinorelbine 25 mg/m2/wk for 12 weeks then every other week plus cisplatin 100 mg/m2 day 1 every 28 days (VC arm).

RESULTS: Six hundred twelve patients were randomized to treatment (205 GC, 204 PCb, and 203 VC). Overall response rates for the GC (30%) and PCb (32%) arms were not significantly different from that of the VC arm (30%). There were no differences in overall survival, time to disease progression, or time to treatment failure. Median survival for the GC, PCb, and VC groups was 9.8, 9.9, and 9.5 months, respectively. Neutropenia was significantly higher on the VC arm (GC 17% or PCb 35% v VC 43% of cycles, P < .001), as was thrombocytopenia on the GC arm (GC 16% v VC 0.1% of cycles, P < .001). Alopecia and peripheral neurotoxicity were most common on the PCb arm, as was nausea/vomiting on the VC arm (P < .05).

CONCLUSION: Efficacy end points were not significantly different between experimental and reference arms, although toxicities showed differences. These findings suggest that chemotherapy in NSCLC has reached a therapeutic plateau.

Presented in part at the Thirty-Seventh Annual Meeting of the American Society of Clinical Oncology, San Francisco, CA, May 12-15, 2001.


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Home page
 Anticancer ResHome page
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Conclusion
Oncologist, January 1, 2008; 13(suppl_1): 37 - 46.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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[Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
P Comella, G Filippelli, G De Cataldis, B Massidda, G Frasci, L Maiorino, C Putzu, S Mancarella, S Palmeri, R Cioffi, et al.
Efficacy of the combination of cisplatin with either gemcitabine and vinorelbine or gemcitabine and paclitaxel in the treatment of locally advanced or metastatic non-small-cell lung cancer: a phase III randomised trial of the Southern Italy Cooperative Oncology Group (SICOG 0101)
Ann. Onc., February 1, 2007; 18(2): 324 - 330.
[Abstract] [Full Text] [PDF]

Home page
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Y Ohe, Y Ohashi, K Kubota, T Tamura, K Nakagawa, S Negoro, Y Nishiwaki, N Saijo, Y Ariyoshi, M Fukuoka, et al.
Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: Four-Arm Cooperative Study in Japan
Ann. Onc., February 1, 2007; 18(2): 317 - 323.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
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Randomized phase II trial of gemcitabine plus weekly versus three-weekly paclitaxel in previously untreated advanced non-small-cell lung cancer
Ann. Onc., January 1, 2007; 18(1): 110 - 115.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
P Ceppi, M Volante, S Novello, I Rapa, K. Danenberg, P. Danenberg, A Cambieri, G Selvaggi, S Saviozzi, R Calogero, et al.
ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine
Ann. Onc., December 1, 2006; 17(12): 1818 - 1825.
[Abstract] [Full Text] [PDF]

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 ThoraxHome page
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Thorax, November 1, 2006; 61(11): 1000 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
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Phase II Trial of Bexarotene Capsules in Patients With Advanced Non-Small-Cell Lung Cancer After Failure of Two or More Previous Therapies
J. Clin. Oncol., October 20, 2006; 24(30): 4848 - 4854.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. R. Molina, A. A. Adjei, and J. R. Jett
Advances in Chemotherapy of Non-small Cell Lung Cancer.
Chest, October 1, 2006; 130(4): 1211 - 1219.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. Inoue, T. Suzuki, T. Fukuhara, M. Maemondo, Y. Kimura, N. Morikawa, H. Watanabe, Y. Saijo, and T. Nukiwa
Prospective Phase II Study of Gefitinib for Chemotherapy-Naive Patients With Advanced Non-Small-Cell Lung Cancer With Epidermal Growth Factor Receptor Gene Mutations
J. Clin. Oncol., July 20, 2006; 24(21): 3340 - 3346.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
R. Booton, P. Lorigan, H. Anderson, S. Baka, L. Ashcroft, M. Nicolson, M. O'Brien, D. Dunlop, K. O'Byrne, V. Laurence, et al.
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Ann. Onc., July 1, 2006; 17(7): 1111 - 1119.
[Abstract] [Full Text] [PDF]

Home page
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A randomized phase II trial comparing every 3-weeks carboplatin/paclitaxel with every 3-weeks carboplatin and weekly paclitaxel in advanced non-small cell lung cancer
Ann. Onc., January 1, 2006; 17(1): 104 - 109.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
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Home page
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Home page
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Randomized Phase II Designs in Cancer Clinical Trials: Current Status and Future Directions
J. Clin. Oncol., July 1, 2005; 23(19): 4450 - 4457.
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Home page
 J Oncol Pharm PractHome page
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Journal of Oncology Pharmacy Practice, June 1, 2005; 11(2): 79 - 81.
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Home page
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J. Clin. Oncol., May 1, 2005; 23(13): 2937 - 2945.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
 Ann OncolHome page
J.-L. Pujol, J.-L. Breton, R. Gervais, P. Rebattu, A. Depierre, J.-F. Morere, B. Milleron, D. Debieuvre, D. Castera, P.-J. Souquet, et al.
Gemcitabine-docetaxel versus cisplatin-vinorelbine in advanced or metastatic non-small-cell lung cancer: a phase III study addressing the case for cisplatin
Ann. Onc., April 1, 2005; 16(4): 602 - 610.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
S. Kobayashi, T. J. Boggon, T. Dayaram, P. A. Janne, O. Kocher, M. Meyerson, B. E. Johnson, M. J. Eck, D. G. Tenen, and B. Halmos
EGFR Mutation and Resistance of Non-Small-Cell Lung Cancer to Gefitinib
N. Engl. J. Med., February 24, 2005; 352(8): 786 - 792.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. V. Scagliotti, C. Kortsik, G. G. Dark, A. Price, C. Manegold, R. Rosell, M. O'Brien, P. M. Peterson, D. Castellano, G. Selvaggi, et al.
Pemetrexed Combined with Oxaliplatin or Carboplatin as First-Line Treatment in Advanced Non-Small Cell Lung Cancer: A Multicenter, Randomized, Phase II Trial
Clin. Cancer Res., January 15, 2005; 11(2): 690 - 696.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
J.-Y. Douillard, R. Gervais, G. Dabouis, A. Le Groumellec, M. D'Arlhac, D. Spaeth, B. Coudert, D. Caillaud, A. Monnier, C. Clary, et al.
Sequential two-line strategy for stage IV non-small-cell lung cancer: docetaxel-cisplatin versus vinorelbine-cisplatin followed by cross-over to single-agent docetaxel or vinorelbine at progression: final results of a randomised phase II study
Ann. Onc., January 1, 2005; 16(1): 81 - 89.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Hu, G. Bebb, S. Tan, R. Ng, H. Yan, J. R. Sartor, L. D. Mayer, and M. B. Bally
Antitumor Efficacy of Oblimersen Bcl-2 Antisense Oligonucleotide Alone and in Combination with Vinorelbine in Xenograft Models of Human Non-Small Cell Lung Cancer
Clin. Cancer Res., November 15, 2004; 10(22): 7662 - 7670.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. Monnerat, T. Le Chevalier, K. Kelly, C. K. Obasaju, J. Brahmer, S. Novello, T. Nakamura, A. M. Liepa, L. Bozec, P. A. Bunn Jr, et al.
Phase II Study of Pemetrexed-Gemcitabine Combination in Patients with Advanced-Stage Non-Small Cell Lung Cancer
Clin. Cancer Res., August 15, 2004; 10(16): 5439 - 5446.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
G. P. Stathopoulos, M. Veslemes, N. Georgatou, D. Antoniou, P. Giamboudakis, K. Katis, D. Tsavdaridis, S. K. Rigatos, I. Dimitroulis, S. Bastani, et al.
Front-line paclitaxel-vinorelbine versus paclitaxel-carboplatin in patients with advanced non-small-cell lung cancer: a randomized phase III trial
Ann. Onc., July 1, 2004; 15(7): 1048 - 1055.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
J. R. Rigas
Taxane-Platinum Combinations in Advanced Non-Small Cell Lung Cancer: A Review
Oncologist, June 2, 2004; 9(suppl_2): 16 - 23.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
J. D. Winegarden, A. M. Mauer, G. A. Otterson, C. M. Rudin, M. A. Villalona-Calero, V. J. Lanzotti, L. Szeto, K. Kasza, P. C. Hoffman, and E. E. Vokes
A phase II study of oxaliplatin and paclitaxel in patients with advanced non-small-cell lung cancer
Ann. Onc., June 1, 2004; 15(6): 915 - 920.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. C. Pulling, B. R. Vuillemenot, J. A. Hutt, T. R. Devereux, and S. A. Belinsky
Aberrant Promoter Hypermethylation of the Death-Associated Protein Kinase Gene Is Early and Frequent in Murine Lung Tumors Induced by Cigarette Smoke and Tobacco Carcinogens
Cancer Res., June 1, 2004; 64(11): 3844 - 3848.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. Dediu
Should We Discard Vinorelbine Plus Cisplatin From the First-Line Therapy of Advanced Non-Small-Cell Lung Cancer?
J. Clin. Oncol., April 1, 2004; 22(7): 1345 - 1347.
[Full Text] [PDF]

Home page
 Ann OncolHome page
C. Gridelli, A. Ardizzoni, T. Le Chevalier, C. Manegold, F. Perrone, N. Thatcher, N. van Zandwijk, M. Di Maio, O. Martelli, and F. De Marinis
Treatment of advanced non-small-cell lung cancer patients with ECOG performance status 2: results of an European Experts Panel
Ann. Onc., March 1, 2004; 15(3): 419 - 426.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. Rosell, K. D. Danenberg, V. Alberola, G. Bepler, J. J. Sanchez, C. Camps, M. Provencio, D. Isla, M. Taron, P. Diz, et al.
Ribonucleotide Reductase Messenger RNA Expression and Survival in Gemcitabine/Cisplatin-Treated Advanced Non-Small Cell Lung Cancer Patients
Clin. Cancer Res., February 15, 2004; 10(4): 1318 - 1325.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
T. Baetz, A. Belch, S. Couban, K. Imrie, J. Yau, R. Myers, K. Ding, N. Paul, L. Shepherd, J. Iglesias, et al.
Gemcitabine, dexamethasone and cisplatin is an active and non-toxic chemotherapy regimen in relapsed or refractory Hodgkin's disease: a phase II study by the National Cancer Institute of Canada Clinical Trials Group
Ann. Onc., December 1, 2003; 14(12): 1762 - 1767.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. A. Belinsky, D. M. Klinge, C. A. Stidley, J.-P. Issa, J. G. Herman, T. H. March, and S. B. Baylin
Inhibition of DNA Methylation and Histone Deacetylation Prevents Murine Lung Cancer
Cancer Res., November 1, 2003; 63(21): 7089 - 7093.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
B. E. Johnson
Adjuvant Chemotherapy for Non-Small-Cell Lung Cancer: The End of the Beginning
J Natl Cancer Inst, October 1, 2003; 95(19): 1422 - 1424.
[Full Text] [PDF]

Home page
 JCOHome page
V. Alberola, C. Camps, M. Provencio, D. Isla, R. Rosell, C. Vadell, I. Bover, A. Ruiz-Casado, P. Azagra, U. Jimenez, et al.
Cisplatin Plus Gemcitabine Versus a Cisplatin-Based Triplet Versus Nonplatinum Sequential Doublets in Advanced Non-Small-Cell Lung Cancer: A Spanish Lung Cancer Group Phase III Randomized Trial
J. Clin. Oncol., September 1, 2003; 21(17): 3207 - 3213.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
P. Harper, T. Plunkett, and D. Khayat
Quality Trials and Quality of Life in Non-Small-Cell Lung Cancer
J. Clin. Oncol., August 15, 2003; 21(16): 3007 - 3008.
[Full Text] [PDF]

Home page
 JCOHome page
F. Fossella, J. R. Pereira, J. von Pawel, A. Pluzanska, V. Gorbounova, E. Kaukel, K. V. Mattson, R. Ramlau, A. Szczesna, P. Fidias, et al.
Randomized, Multinational, Phase III Study of Docetaxel Plus Platinum Combinations Versus Vinorelbine Plus Cisplatin for Advanced Non-Small-Cell Lung Cancer: The TAX 326 Study Group
J. Clin. Oncol., August 15, 2003; 21(16): 3016 - 3024.
[Abstract] [Full Text] [PDF]


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