Journal of Clinical Oncology, Vol 20, Issue 4
(February), 2002: 1043-1048
© 2002 American Society for Clinical Oncology
Immunohistochemistry Versus Microsatellite Instability Testing in Phenotyping Colorectal Tumors
By Noralane M. Lindor,
Lawrence J. Burgart,
Olga Leontovich,
Richard M. Goldberg,
Julie M. Cunningham,
Daniel J. Sargent,
Catherine Walsh-Vockley,
Gloria M. Petersen,
Michael D. Walsh,
Barbara A. Leggett,
Joanne P. Young,
Melissa A. Barker,
Jeremy R. Jass,
John Hopper,
Steve Gallinger,
Bharati Bapat,
Mark Redston,
Stephen N. Thibodeau for the Cooperative Family Registry for Colon Cancer Studies
From the Departments of Medical Genetics, Laboratory Medicine and Pathology, Oncology, Biostatistics, and Clinical Epidemiology, Mayo Foundation, Rochester, MN; Pathology Department, University of Queensland, Queensland; Conjoint Gastroenterology Laboratory, Royal Brisbane Hospital, Brisbane; Department of General Practice and Public Health, University of Melbourne, Victoria, Australia; Departments of Surgery and Pathology, Mt Sinai Hospital, Toronto, Ontario, Canada; and Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA.
Address reprints requests to Noralane M. Lindor, MD, E7B Medical Genetics, Mayo Clinic, 200 First St, SW, Rochester, MN 55905; email: nlindor{at}mayo.edu
PURPOSE: To compare microsatellite instability (MSI) testing with immunohistochemical (IHC) detection of hMLH1 and hMSH2 in colorectal cancer.
PATIENTS AND METHODS: Colorectal cancers from 1,144 patients were assessed for DNA mismatch repair deficiency by two methods: MSI testing and IHC detection of hMLH1 and hMSH2 gene products. High-frequency MSI (MSI-H) was defined as more than 30% instability of at least five markers; low-level MSI (MSI-L) was defined as 1% to 29% of loci unstable.
RESULTS: Of 1,144 tumors tested, 818 showed intact expression of hMLH1 and hMSH2. Of these, 680 were microsatellite stable (MSS), 27 were MSI-H, and 111 were MSI-L. In all, 228 tumors showed absence of hMLH1 expression and 98 showed absence of hMSH2 expression: all were MSI-H.
CONCLUSION: IHC in colorectal tumors for protein products hMLH1 and hMSH2 provides a rapid, cost-effective, sensitive (92.3%), and extremely specific (100%) method for screening for DNA mismatch repair defects. The predictive value of normal IHC for an MSS/MSI-L phenotype was 96.7%, and the predictive value of abnormal IHC was 100% for an MSI-H phenotype. Testing strategies must take into account acceptability of missing some cases of MSI-H tumors if only IHC is performed.
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102(3):
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|
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C. Eveno, J. Nemeth, H. Soliman, F. Praz, H. de The, P. Valleur, I. C. Talbot, and M. Pocard
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January 1, 2010;
145(1):
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M P Hitchins and R L Ward
Constitutional (germline) MLH1 epimutation as an aetiological mechanism for hereditary non-polyposis colorectal cancer
J. Med. Genet.,
December 1, 2009;
46(12):
793 - 802.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Cicek, S. L. Slager, S. J. Achenbach, A. J. French, H. E. Blair, S. R. Fink, N. R. Foster, B. F. Kabat, K. C. Halling, J. M. Cunningham, et al.
Functional and Clinical Significance of Variants Localized to 8q24 in Colon Cancer
Cancer Epidemiol. Biomarkers Prev.,
September 1, 2009;
18(9):
2492 - 2500.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Bapat, N. M. Lindor, J. Baron, K. Siegmund, L. Li, Y. Zheng, R. Haile, S. Gallinger, J. R. Jass, J. P. Young, et al.
The Association of Tumor Microsatellite Instability Phenotype with Family History of Colorectal Cancer
Cancer Epidemiol. Biomarkers Prev.,
March 1, 2009;
18(3):
967 - 975.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Oman, L. Ballinger, and L. A. Cerilli
Small Cell Carcinoma: Arising in Lynch Syndrome: A Previously Undocumented Occurrence
International Journal of Surgical Pathology,
February 1, 2009;
17(1):
46 - 50.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. N. Poynter, K. D. Siegmund, D. J. Weisenberger, T. I. Long, S. N. Thibodeau, N. Lindor, J. Young, M. A. Jenkins, J. L. Hopper, J. A. Baron, et al.
Molecular Characterization of MSI-H Colorectal Cancer by MLHI Promoter Methylation, Immunohistochemistry, and Mismatch Repair Germline Mutation Screening
Cancer Epidemiol. Biomarkers Prev.,
November 1, 2008;
17(11):
3208 - 3215.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. R. English, J. P. Young, J. A. Simpson, M. A. Jenkins, M. C. Southey, M. D. Walsh, D. D. Buchanan, M. A. Barker, A. M. Haydon, S. G. Royce, et al.
Ethnicity and Risk for Colorectal Cancers Showing Somatic BRAF V600E Mutation or CpG Island Methylator Phenotype
Cancer Epidemiol. Biomarkers Prev.,
July 1, 2008;
17(7):
1774 - 1780.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Zlobec, L. M. Terracciano, and A. Lugli
Local Recurrence in Mismatch Repair-Proficient Colon Cancer Predicted by an Infiltrative Tumor Border and Lack of CD8+ Tumor-Infiltrating Lymphocytes
Clin. Cancer Res.,
June 15, 2008;
14(12):
3792 - 3797.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Zlobec, K. Baker, L. M. Terracciano, and A. Lugli
RHAMM, p21 Combined Phenotype Identifies Microsatellite Instability-High Colorectal Cancers with a Highly Adverse Prognosis
Clin. Cancer Res.,
June 15, 2008;
14(12):
3798 - 3806.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Chan, J. A. Meyerhardt, D. Niedzwiecki, D. Hollis, L. B. Saltz, R. J. Mayer, J. Thomas, P. Schaefer, R. Whittom, A. Hantel, et al.
Association of Family History With Cancer Recurrence and Survival Among Patients With Stage III Colon Cancer
JAMA,
June 4, 2008;
299(21):
2515 - 2523.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. French, D. J. Sargent, L. J. Burgart, N. R. Foster, B. F. Kabat, R. Goldberg, L. Shepherd, H. E. Windschitl, and S. N. Thibodeau
Prognostic Significance of Defective Mismatch Repair and BRAF V600E in Patients with Colon Cancer
Clin. Cancer Res.,
June 1, 2008;
14(11):
3408 - 3415.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Walsh, M. C. Cummings, D. D. Buchanan, W. M. Dambacher, S. Arnold, D. McKeone, R. Byrnes, M. A. Barker, B. A. Leggett, M. Gattas, et al.
Molecular, Pathologic, and Clinical Features of Early-Onset Endometrial Cancer: Identifying Presumptive Lynch Syndrome Patients
Clin. Cancer Res.,
March 15, 2008;
14(6):
1692 - 1700.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Mrkonjic, S. Raptis, R. C. Green, N. Monga, D. Daftary, E. Dicks, H.B. Younghusband, P. S. Parfrey, S. S. Gallinger, J. R. McLaughlin, et al.
MSH2 118T>C and MSH6 159C>T promoter polymorphisms and the risk of colorectal cancer
Carcinogenesis,
December 1, 2007;
28(12):
2575 - 2580.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. R. Turner, C. Li, and C. C. Compton
Newer Pathologic Assessment Techniques for Colorectal Carcinoma
Clin. Cancer Res.,
November 15, 2007;
13(22):
6871s - 6876s.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Newcomb, J. Baron, M. Cotterchio, S. Gallinger, J. Grove, R. Haile, D. Hall, J. L. Hopper, J. Jass, L. Le Marchand, et al.
Colon Cancer Family Registry: An International Resource for Studies of the Genetic Epidemiology of Colon Cancer
Cancer Epidemiol. Biomarkers Prev.,
November 1, 2007;
16(11):
2331 - 2343.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Watson, F. Grieu, M. Morris, J. Harvey, C. Stewart, L. Schofield, J. Goldblatt, and B. Iacopetta
Heterogeneous Staining for Mismatch Repair Proteins during Population-Based Prescreening for Hereditary Nonpolyposis Colorectal Cancer
J. Mol. Diagn.,
September 1, 2007;
9(4):
472 - 478.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Newcomb, Y. Zheng, V. M. Chia, L. M. Morimoto, V. P. Doria-Rose, A. Templeton, S. N. Thibodeau, and J. D. Potter
Estrogen Plus Progestin Use, Microsatellite Instability, and the Risk of Colorectal Cancer in Women
Cancer Res.,
August 1, 2007;
67(15):
7534 - 7539.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Khilko, P. Bourne, Qi Yang, and Ping Tang
Mismatch Repair Genes hMLH1 and hMSH2 May Not Play an Essential Role in Breast Carcinogenesis
International Journal of Surgical Pathology,
July 1, 2007;
15(3):
233 - 241.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Raptis, M. Mrkonjic, R. C. Green, V. V. Pethe, N. Monga, Y. M. Chan, D. Daftary, E. Dicks, B. H. Younghusband, P. S. Parfrey, et al.
MLH1 -93G>A Promoter Polymorphism and the Risk of Microsatellite-Unstable Colorectal Cancer
J Natl Cancer Inst,
March 21, 2007;
99(6):
463 - 474.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. T. Lynch, J. F. Lynch, and P. M. Lynch
Toward a Consensus in Molecular Diagnosis of Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome)
J Natl Cancer Inst,
February 21, 2007;
99(4):
261 - 263.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R C Niessen, M J W Berends, Y Wu, R H Sijmons, H Hollema, M J L Ligtenberg, H E K de Walle, E G E de Vries, A Karrenbeld, C H C M Buys, et al.
Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non-polyposis colorectal cancer
Gut,
December 1, 2006;
55(12):
1781 - 1788.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Y. Locker, S. Hamilton, J. Harris, J. M. Jessup, N. Kemeny, J. S. Macdonald, M. R. Somerfield, D. F. Hayes, and R. C. Bast Jr
ASCO 2006 Update of Recommendations for the Use of Tumor Markers in Gastrointestinal Cancer
J. Clin. Oncol.,
November 20, 2006;
24(33):
5313 - 5327.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. G. Guillem, W. C. Wood, J. F. Moley, A. Berchuck, B. Y. Karlan, D. G. Mutch, R. F. Gagel, J. Weitzel, M. Morrow, B. L. Weber, et al.
ASCO/SSO Review of Current Role of Risk-Reducing Surgery in Common Hereditary Cancer Syndromes
J. Clin. Oncol.,
October 1, 2006;
24(28):
4642 - 4660.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Chen, W. Wang, S. Lee, K. Nafa, J. Lee, K. Romans, P. Watson, S. B. Gruber, D. Euhus, K. W. Kinzler, et al.
Prediction of germline mutations and cancer risk in the Lynch syndrome.
JAMA,
September 27, 2006;
296(12):
1479 - 1487.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. M. Lindor, G. M. Petersen, D. W. Hadley, A. Y. Kinney, S. Miesfeldt, K. H. Lu, P. Lynch, W. Burke, and N. Press
Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: a systematic review.
JAMA,
September 27, 2006;
296(12):
1507 - 1517.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. M.C. Hendriks, A. E. de Jong, H. Morreau, C. M.J. Tops, H. F. Vasen, J. Th. Wijnen, M. H. Breuning, and A. H.J.T. Brocker-Vriends
Diagnostic Approach and Management of Lynch Syndrome (Hereditary Nonpolyposis Colorectal Carcinoma): A Guide for Clinicians
CA Cancer J Clin,
July 1, 2006;
56(4):
213 - 225.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. M. Chia, P. A. Newcomb, J. Bigler, L. M. Morimoto, S. N. Thibodeau, and J. D. Potter
Risk of Microsatellite-Unstable Colorectal Cancer Is Associated Jointly with Smoking and Nonsteroidal Anti-inflammatory Drug Use.
Cancer Res.,
July 1, 2006;
66(13):
6877 - 6883.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Lanza, R. Gafa, A. Santini, I. Maestri, L. Guerzoni, and L. Cavazzini
Immunohistochemical Test for MLH1 and MSH2 Expression Predicts Clinical Outcome in Stage II and III Colorectal Cancer Patients
J. Clin. Oncol.,
May 20, 2006;
24(15):
2359 - 2367.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. A. Sinicrope, R. L. Rego, K. C. Halling, N. R. Foster, D. J. Sargent, B. La Plant, A. J. French, C. J. Allegra, J. A. Laurie, R. M. Goldberg, et al.
Thymidylate synthase expression in colon carcinomas with microsatellite instability.
Clin. Cancer Res.,
May 1, 2006;
12(9):
2738 - 2744.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Yamamoto, H. Matsuyama, S. Kawauchi, T. Furuya, X. P. Liu, K. Ikemoto, A. Oga, K. Naito, and K. Sasaki
Biological characteristics in bladder cancer depend on the type of genetic instability.
Clin. Cancer Res.,
May 1, 2006;
12(9):
2752 - 2758.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y Mueller-Koch, H Vogelsang, R Kopp, P Lohse, G Keller, D Aust, M Muders, M Gross, J Daum, U Schiemann, et al.
Hereditary non-polyposis colorectal cancer: clinical and molecular evidence for a new entity of hereditary colorectal cancer
Gut,
December 1, 2005;
54(12):
1733 - 1740.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. P. Giacomini, S. Y. Leung, X. Chen, S. T. Yuen, Y. H. Kim, E. Bair, and J. R. Pollack
A Gene Expression Signature of Genetic Instability in Colon Cancer
Cancer Res.,
October 15, 2005;
65(20):
9200 - 9205.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Llor, E. Pons, R. M. Xicola, A. Castells, C. Alenda, V. Pinol, M. Andreu, S. Castellvi-Bel, A. Paya, R. Jover, et al.
Differential Features of Colorectal Cancers Fulfilling Amsterdam Criteria without Involvement of the Mutator Pathway
Clin. Cancer Res.,
October 15, 2005;
11(20):
7304 - 7310.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Southey, M. A. Jenkins, L. Mead, J. Whitty, M. Trivett, A. A. Tesoriero, L. D. Smith, K. Jennings, G. Grubb, S. G. Royce, et al.
Use of Molecular Tumor Characteristics to Prioritize Mismatch Repair Gene Testing in Early-Onset Colorectal Cancer
J. Clin. Oncol.,
September 20, 2005;
23(27):
6524 - 6532.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Findeisen, M. Kloor, S. Merx, C. Sutter, S. M. Woerner, N. Dostmann, A. Benner, B. Dondog, M. Pawlita, W. Dippold, et al.
T25 Repeat in the 3' Untranslated Region of the CASP2 Gene: A Sensitive and Specific Marker for Microsatellite Instability in Colorectal Cancer
Cancer Res.,
September 15, 2005;
65(18):
8072 - 8078.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gill, N. M. Lindor, L. J. Burgart, R. Smalley, O. Leontovich, A. J. French, R. M. Goldberg, D. J. Sargent, J. R. Jass, J. L. Hopper, et al.
Isolated Loss of PMS2 Expression in Colorectal Cancers: Frequency, Patient Age, and Familial Aggregation
Clin. Cancer Res.,
September 15, 2005;
11(18):
6466 - 6471.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ollikainen, W. M. Abdel-Rahman, A.-L. Moisio, A. Lindroos, R. Kariola, I. Jarvela, M. Poyhonen, R. Butzow, and P. Peltomaki
Molecular Analysis of Familial Endometrial Carcinoma: A Manifestation of Hereditary Nonpolyposis Colorectal Cancer or a Separate Syndrome?
J. Clin. Oncol.,
July 20, 2005;
23(21):
4609 - 4616.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Wark, M. P. Weijenberg, P. van 't Veer, G. van Wijhe, M. Luchtenborg, G. N.P. van Muijen, A. F.P.M. de Goeij, R. A. Goldbohm, and P. A. van den Brandt
Fruits, Vegetables, and hMLH1 Protein-Deficient and -Proficient Colon Cancer: The Netherlands Cohort Study
Cancer Epidemiol. Biomarkers Prev.,
July 1, 2005;
14(7):
1619 - 1625.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Chen, P. Watson, and G. Parmigiani
Accuracy of MSI testing in predicting germline mutations of MSH2 and MLH1: a case study in Bayesian meta-analysis of diagnostic tests without a gold standard
Biostat.,
July 1, 2005;
6(3):
450 - 464.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Hampel, W. L. Frankel, E. Martin, M. Arnold, K. Khanduja, P. Kuebler, H. Nakagawa, K. Sotamaa, T. W. Prior, J. Westman, et al.
Screening for the Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer)
N. Engl. J. Med.,
May 5, 2005;
352(18):
1851 - 1860.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. M. Lindor, K. Rabe, G. M. Petersen, R. Haile, G. Casey, J. Baron, S. Gallinger, B. Bapat, M. Aronson, J. Hopper, et al.
Lower Cancer Incidence in Amsterdam-I Criteria Families Without Mismatch Repair Deficiency: Familial Colorectal Cancer Type X
JAMA,
April 27, 2005;
293(16):
1979 - 1985.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Pinol, A. Castells, M. Andreu, S. Castellvi-Bel, C. Alenda, X. Llor, R. M. Xicola, F. Rodriguez-Moranta, A. Paya, R. Jover, et al.
Accuracy of Revised Bethesda Guidelines, Microsatellite Instability, and Immunohistochemistry for the Identification of Patients With Hereditary Nonpolyposis Colorectal Cancer
JAMA,
April 27, 2005;
293(16):
1986 - 1994.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. F. A. Vasen and C. R. Boland
Progress in Genetic Testing, Classification, and Identification of Lynch Syndrome
JAMA,
April 27, 2005;
293(16):
2028 - 2030.
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Casey, N. M. Lindor, N. Papadopoulos, S. N. Thibodeau, J. Moskow, S. Steelman, C. H. Buzin, S. S. Sommer, C. E. Collins, M. Butz, et al.
Conversion Analysis for Mutation Detection in MLH1 and MSH2 in Patients With Colorectal Cancer
JAMA,
February 16, 2005;
293(7):
799 - 809.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Garber and K. Offit
Hereditary Cancer Predisposition Syndromes
J. Clin. Oncol.,
January 10, 2005;
23(2):
276 - 292.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L.R. Lipton, V. Johnson, C. Cummings, S. Fisher, P. Risby, A.T. Eftekhar Sadat, T. Cranston, L. Izatt, P. Sasieni, S.V. Hodgson, et al.
Refining the Amsterdam Criteria and Bethesda Guidelines: Testing Algorithms for the Prediction of Mismatch Repair Mutation Status in the Familial Cancer Clinic
J. Clin. Oncol.,
December 15, 2004;
22(24):
4934 - 4943.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B Perez-Ordonez, N N Huynh, K W Berean, and R C K Jordan
Expression of mismatch repair proteins, {beta} catenin, and E cadherin in intestinal-type sinonasal adenocarcinoma
J. Clin. Pathol.,
October 1, 2004;
57(10):
1080 - 1083.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K Baker, Y Zhang, C Jin, and J R Jass
Proximal versus distal hyperplastic polyps of the colorectum: different lesions or a biological spectrum?
J. Clin. Pathol.,
October 1, 2004;
57(10):
1089 - 1093.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Kim, K. H. Lee, I. H. Ka, K. H. Koo, S. A. Roh, H. C. Kim, C. S. Yu, T. W. Kim, H. M. Chang, G. Y. Gong, et al.
Characterization of Mutator Phenotype in Familial Colorectal Cancer Patients Not Fulfilling Amsterdam Criteria
Clin. Cancer Res.,
September 15, 2004;
10(18):
6159 - 6168.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T Kambara, L A Simms, V L J Whitehall, K J Spring, C V A Wynter, M D Walsh, M A Barker, S Arnold, A McGivern, N Matsubara, et al.
BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum
Gut,
August 1, 2004;
53(8):
1137 - 1144.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Garrity, L. J. Burgart, M. R. Mahoney, H. E. Windschitl, M. Salim, M. Wiesenfeld, J. E. Krook, J. C. Michalak, R. M. Goldberg, M. J. O'Connell, et al.
Prognostic Value of Proliferation, Apoptosis, Defective DNA Mismatch Repair, and p53 Overexpression in Patients With Resected Dukes' B2 or C Colon Cancer: A North Central Cancer Treatment Group Study
J. Clin. Oncol.,
May 1, 2004;
22(9):
1572 - 1582.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Tang, C. R. Changchien, M.-C. Wu, C.-W. Fan, K.-W. Liu, J.-S. Chen, H.-T. Chien, and L.-L. Hsieh
Colorectal cancer without high microsatellite instability and chromosomal instability--an alternative genetic pathway to human colorectal cancer
Carcinogenesis,
May 1, 2004;
25(5):
841 - 846.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Umar, C. R. Boland, J. P. Terdiman, S. Syngal, A. d. l. Chapelle, J. Ruschoff, R. Fishel, N. M. Lindor, L. J. Burgart, R. Hamelin, et al.
Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability
J Natl Cancer Inst,
February 18, 2004;
96(4):
261 - 268.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. de Jong, M. van Puijenbroek, Y. Hendriks, C. Tops, J. Wijnen, M. G. E. M. Ausems, H. Meijers-Heijboer, A. Wagner, T. A. M. van Os, A. H. J. T. Brocker-Vriends, et al.
Microsatellite Instability, Immunohistochemistry, and Additional PMS2 Staining in Suspected Hereditary Nonpolyposis Colorectal Cancer
Clin. Cancer Res.,
February 1, 2004;
10(3):
972 - 980.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Svrcek, F Jourdan, N Sebbagh, A Couvelard, D Chatelain, N Mourra, S Olschwang, D Wendum, and J-F Flejou
Immunohistochemical analysis of adenocarcinoma of the small intestine: a tissue microarray study
J. Clin. Pathol.,
December 1, 2003;
56(12):
898 - 903.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Diergaarde, H. Braam, G. N. P. van Muijen, M. J. L. Ligtenberg, F. J. Kok, and E. Kampman
Dietary Factors and Microsatellite Instability in Sporadic Colon Carcinomas
Cancer Epidemiol. Biomarkers Prev.,
November 1, 2003;
12(11):
1130 - 1136.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G.M. Nash, M. Gimbel, J. Shia, A.T. Culliford, D.R. Nathanson, M. Ndubuisi, Y. Yamaguchi, Z.S. Zeng, F. Barany, and P.B. Paty
Automated, Multiplex Assay for High-Frequency Microsatellite Instability in Colorectal Cancer
J. Clin. Oncol.,
August 15, 2003;
21(16):
3105 - 3112.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H Bonte and J-F Flejou
Patterns of expression of MMR proteins in serrated adenomas and other polyps of the colorectum
Gut,
April 1, 2003;
52(4):
611 - 611.
[Full Text]
|
|
|
|
|
|
|
A. Goel, C. N. Arnold, D. Niedzwiecki, D. K. Chang, L. Ricciardiello, J. M. Carethers, J. M. Dowell, L. Wasserman, C. Compton, R. J. Mayer, et al.
Characterization of Sporadic Colon Cancer by Patterns of Genomic Instability
Cancer Res.,
April 1, 2003;
63(7):
1608 - 1614.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. C. Chung and A. K. Rustgi
The Hereditary Nonpolyposis Colorectal Cancer Syndrome: Genetics and Clinical Implications
Ann Intern Med,
April 1, 2003;
138(7):
560 - 570.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Peltomaki
Role of DNA Mismatch Repair Defects in the Pathogenesis of Human Cancer
J. Clin. Oncol.,
March 15, 2003;
21(6):
1174 - 1179.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. T. Lynch and A. de la Chapelle
Hereditary Colorectal Cancer
N. Engl. J. Med.,
March 6, 2003;
348(10):
919 - 932.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S. Wahlberg, J. Schmeits, G. Thomas, M. Loda, J. Garber, S. Syngal, R. D. Kolodner, and E. Fox
Evaluation of Microsatellite Instability and Immunohistochemistry for the Prediction of Germ-Line MSH2 and MLH1 Mutations in Hereditary Nonpolyposis Colon Cancer Families
Cancer Res.,
June 1, 2002;
62(12):
3485 - 3492.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. de la Chapelle
Microsatellite Instability Phenotype of Tumors: Genotyping or Immunohistochemistry? The Jury Is Still Out
J. Clin. Oncol.,
February 15, 2002;
20(4):
897 - 899.
[Full Text]
[PDF]
|
|
|
|
