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DNA Microarrays in Clinical Oncology

From the Departments of Adult Oncology and Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston; and Whitehead Institute/MIT Center for Genome Research, Cambridge, MA.

Address reprint requests to Todd R. Golub, MD, Dana-Farber Cancer Institute, 44 Binney St, D640, Boston, MA 02115; email: golub{at}genome.wi.mit.edu

ABSTRACT: Aberrant gene expression is critical for tumor initiation and progression. However, we lack a comprehensive understanding of all genes that are aberrantly expressed in human cancer. Recently, DNA microarrays have been used to obtain global views of human cancer gene expression and to identify genetic markers that might be important for diagnosis and therapy. We review clinical applications of these novel tools, discuss some important recent studies, identify promising avenues of research in this emerging field of study, and discuss the likely impact that expression profiling will have on clinical oncology.

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