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Older Age Is an Adverse Prognostic Factor in Stage I, Favorable Histology Wilms’ Tumor Treated With Vincristine Monochemotherapy: A Study by the United Kingdom Children’s Cancer Study Group, Wilm’s Tumor Working Group

K. Pritchard-Jones, A. Kelsey, G. Vujanic, J. Imeson, C. Hutton, C. Mitchell

From the Department of Paediatric Oncology, Royal Marsden Hospital/Institute of Cancer Research, Sutton; Department of Histopathology, Royal Manchester Children’s Hospital, Manchester; Department of Histopathology, University Hospital of Wales, Cardiff; United Kingdom Children’s Cancer Study Group Data Centre, Leicester; and John Radcliffe Hospital, Oxford, United Kingdom.

Address reprint requests to K. Pritchard-Jones, MD, Department of Paediatric Oncology, Institute of Cancer Research/Royal Marsden Hospital, Brookes Lawley Bldg, Cotswold Rd, Sutton, Surrey, SM2 5NG, United Kingdom; e-mail: kathy.pritchard-jones{at}icr.ac.uk.

Purpose: To identify clinical prognostic factors in children with stage I, favorable histology (FH) Wilms’ tumor treated with vincristine monochemotherapy after immediate nephrectomy to define subgroups for consideration of further reduction in treatment intensity.

Patients and Methods: During two consecutive trials of the United Kingdom Children’s Cancer Study Group (UKW2 and UKW3, 1986 to 2001), 242 children with stage I FH Wilms’ tumor were treated with immediate nephrectomy followed by 10 weekly injections of vincristine 1.5 mg/m². Event-free survival (EFS) and overall survival (OS) were compared by age group.

Results: The 4-year EFS rate was 93.2%, 87.2%, and 71.3% for children less than 2 years old, 2 to 4 years old, and 4 years old or older at diagnosis, respectively (log-rank, P = .001); the corresponding 4-year OS rate was 98.1%, 95.0%, and 87.2% (log-rank, P = .01). There were no toxicity- or procedure-related deaths. In multivariate analysis, specimen weight was not of independent prognostic value (P = .66). Among the 186 children younger than 4 years at diagnosis, there were 17 relapses and five deaths, compared with 16 relapses and eight deaths among the 56 children at least 4 years old at diagnosis. OS after relapse was surprisingly poor (61.6% at 4 years).

Conclusion: Treatment for stage I FH Wilms’ tumor is generally successful using vincristine monotherapy after immediate nephrectomy, and therefore, the risks of dactinomycin hepatopathy can be avoided. However, age at least 4 years is a significant adverse prognostic factor. This treatment schedule should be considered in any trial of treatment reduction in very young children with stage I FH Wilms’ tumor, regardless of tumor size, and we suggest that the upper age limit for the reduced therapy be set at 4 years.

Supported by Cancer Research United Kingdom and Royal Marsden Hospital Charitable Funds, Sutton, United Kingdom.

Presented at the Thirty-Fourth Congress of the International Society of Paediatric Oncology, Porto, Portugal, October 11, 2003.

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