Originally published as JCO Early Release 10.1200/JCO.2003.12.005 on October 14 2003

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Save to my personal folders Download to citation manager Rights & Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bear, H. D. Articles by Wolmark, N. Search for Related Content PubMed PubMed Citation Articles by Bear, H. D. Articles by Wolmark, N. Social Bookmarking                            What's this?

The Effect on Tumor Response of Adding Sequential Preoperative Docetaxel to Preoperative Doxorubicin and Cyclophosphamide: Preliminary Results From National Surgical Adjuvant Breast and Bowel Project Protocol B-27

Harry D. Bear, Stewart Anderson, Ann Brown, Roy Smith, Eleftherios P. Mamounas, Bernard Fisher, Richard Margolese, Heather Theoret, Atilla Soran, D. Lawrence Wickerham, Norman Wolmark

From the Virginia Commonwealth University, Medical College of Virginia School of Medicine, Richmond, VA; National Surgical Adjuvant Breast and Bowel Project; University of Pittsburgh, Graduate School of Public Health; University of Pittsburgh Medical Center, Pittsburgh; Medical College of Pennsylvania/Hahnemann University, Philadelphia, PA; Aultman Hospital Cancer Center, Canton, OH; Jewish General Hospital, Montreal, Quebec.

Address reprint requests to Harry D. Bear, MD, PhD, Box 980011, Division of Surgical Oncology, VCUHS, Richmond, VA 23298-0011; e-mail: hbear{at}hsc.vcu.edu.

Purpose: The National Surgical Adjuvant Breast and Bowel Project Protocol B-27 was designed to determine the effect of adding docetaxel after four cycles of preoperative doxorubicin and cyclophosphamide (AC) on clinical and pathological response rates and on disease-free and overall survival of women with operable breast cancer.

Patients and Methods: Women (N = 2,411) with operable primary breast cancer were randomly assigned to receive either four cycles of preoperative AC followed by surgery (group I), or four cycles of AC followed by four cycles of docetaxel, followed by surgery (group II), or four cycles of AC followed by surgery and then four cycles of docetaxel (group III). Clinical and pathologic tumor responses to preoperative therapy were assessed.

Results: Mean tumor size (4.5 cm) and other key characteristics were evenly balanced among the three treatment arms. Grade 4 toxicity was observed in 10.3% of 2,400 patients during AC treatment, and in 23.4% of 1584 patients during docetaxel treatment. Compared to preoperative AC alone, preoperative AC followed by docetaxel increased the clinical complete response rate (40.1% v 63.6%; P < .001), the overall clinical response rate (85.5% v 90.7%; P < .001), the pathologic complete response rate (13.7% v 26.1%; P < .001), and the proportion of patients with negative nodes (50.8% v 58.2%; P < .001). Pathologic primary breast tumor response was a significant predictor of pathologic nodal status (P < .001).

Conclusion: The addition of four cycles of preoperative docetaxel after four cycles of preoperative AC significantly increased clinical and pathologic response rates for operable breast cancer.

This investigation was supported by Public Health Service Grants U10-CA-37377, U10-CA-69974, U10-CA12027, and U10-CA-69651 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services.

Preliminary results of this study were presented, in part, at the 24^th Annual San Antonio Breast Cancer Symposium, San Antonio, TX, December 10, 2001.

Drs Bear and Mamounas have served on advisory panels for and received honorarium payments for CME activities from Aventis Pharmaceuticals.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. A. Bauer, A. B. Chakravarthy, J. M. Rosenbluth, D. Mi, E. H. Seeley, N. De Matos Granja-Ingram, M. G. Olivares, M. C. Kelley, I. A. Mayer, I. M. Meszoely, et al. Identification of Markers of Taxane Sensitivity Using Proteomic and Genomic Analyses of Breast Tumors from Patients Receiving Neoadjuvant Paclitaxel and Radiation Clin. Cancer Res., January 15, 2010; 16(2): 681 - 690. [Abstract] [Full Text] [PDF]

				M. T. Ionta, F. Atzori, M. C. Deidda, V. Pusceddu, S. Palmeri, B. Frau, M. Murgia, M. Barca, L. Minerba, and B. Massidda Long-Term Outcomes in Stage IIIB Breast Cancer Patients Who Achieved Less Than a Pathological Complete Response ( Oncologist, November 1, 2009; 14(11): 1051 - 1060. [Abstract] [Full Text] [PDF]

				H. Jinno, M. Sakata, T. Hayashida, M. Takahashi, M. Mukai, T. Ikeda, and Y. Kitagawa A phase II trial of capecitabine and docetaxel followed by 5-fluorouracil/epirubicin/cyclophosphamide (FEC) as preoperative treatment in women with stage II/III breast cancer Ann. Onc., October 23, 2009; (2009) mdp428v1. [Abstract] [Full Text] [PDF]

				C. Shimizu, N. Masuda, K. Yoshimura, H. Tsuda, M. Mano, M. Ando, K. Tamura, and Y. Fujiwara Long-term Outcome and Pattern of Relapse after Neoadjuvant Chemotherapy in Patients with Human Epidermal Growth Factor Receptor 2-positive Primary Breast Cancer Jpn. J. Clin. Oncol., August 1, 2009; 39(8): 484 - 490. [Abstract] [Full Text] [PDF]

				M. Colleoni, V. Bagnardi, N. Rotmensz, S. Dellapasqua, G. Viale, G. Pruneri, P. Veronesi, R. Torrisi, A. Luini, M. Intra, et al. A risk score to predict disease-free survival in patients not achieving a pathological complete remission after preoperative chemotherapy for breast cancer Ann. Onc., July 1, 2009; 20(7): 1178 - 1184. [Abstract] [Full Text] [PDF]

				G. Frasci, P. Comella, M. Rinaldo, G. Iodice, M. Di Bonito, M. D'Aiuto, A. Petrillo, S. Lastoria, C. Siani, G. Comella, et al. Preoperative weekly cisplatin-epirubicin-paclitaxel with G-CSF support in triple-negative large operable breast cancer Ann. Onc., July 1, 2009; 20(7): 1185 - 1192. [Abstract] [Full Text] [PDF]

				C. H. Barrios, C. Sampaio, J. Vinholes, and R. Caponero What is the role of chemotherapy in estrogen receptor-positive, advanced breast cancer? Ann. Onc., July 1, 2009; 20(7): 1157 - 1162. [Abstract] [Full Text] [PDF]

				M. Untch, V. Mobus, W. Kuhn, B. R. Muck, C. Thomssen, I. Bauerfeind, N. Harbeck, C. Werner, A. Lebeau, A. Schneeweiss, et al. Intensive Dose-Dense Compared With Conventionally Scheduled Preoperative Chemotherapy for High-Risk Primary Breast Cancer J. Clin. Oncol., June 20, 2009; 27(18): 2938 - 2945. [Abstract] [Full Text] [PDF]

				T. Tanei, K. Morimoto, K. Shimazu, S. J. Kim, Y. Tanji, T. Taguchi, Y. Tamaki, and S. Noguchi Association of Breast Cancer Stem Cells Identified by Aldehyde Dehydrogenase 1 Expression with Resistance to Sequential Paclitaxel and Epirubicin-Based Chemotherapy for Breast Cancers Clin. Cancer Res., June 15, 2009; 15(12): 4234 - 4241. [Abstract] [Full Text] [PDF]

				L. MIGLIETTA, P. VANELLA, L. CANOBBIO, M. A. PARODI, P. GUGLIELMINI, and F. BOCCARDO Clinical and Pathological Response to Primary Chemotherapy in Patients with Locally Advanced Breast Cancer Grouped According to Hormonal Receptors, Her2 Status, Grading and Ki-67 Proliferation Index Anticancer Res, May 1, 2009; 29(5): 1621 - 1625. [Abstract] [Full Text] [PDF]

				J. A. Sparano, S. Moulder, A. Kazi, D. Coppola, A. Negassa, L. Vahdat, T. Li, C. Pellegrino, S. Fineberg, P. Munster, et al. Phase II Trial of Tipifarnib plus Neoadjuvant Doxorubicin-Cyclophosphamide in Patients with Clinical Stage IIB-IIIC Breast Cancer Clin. Cancer Res., April 15, 2009; 15(8): 2942 - 2948. [Abstract] [Full Text] [PDF]

				G. Mustacchi, M. Mansutti, C. Sacco, S. Barni, A. Farris, M. Cazzaniga, M. Cozzi, and C. Dellach Neo-adjuvant exemestane in elderly patients with breast cancer: a phase II, multicentre, open-label, Italian study Ann. Onc., April 1, 2009; 20(4): 655 - 659. [Abstract] [Full Text] [PDF]

				J.-M. Classe, V. Bordes, L. Campion, H. Mignotte, F. Dravet, J. Leveque, C. Sagan, P. F. Dupre, G. Body, and S. Giard Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy for Advanced Breast Cancer: Results of Ganglion Sentinelle et Chimiotherapie Neoadjuvante, a French Prospective Multicentric Study J. Clin. Oncol., February 10, 2009; 27(5): 726 - 732. [Abstract] [Full Text] [PDF]

				J. Baselga, M. Zambetti, A. Llombart-Cussac, G. Manikhas, E. Kubista, G. G. Steger, A. Makhson, S. Tjulandin, H. Ludwig, M. Verrill, et al. Phase II Genomics Study of Ixabepilone as Neoadjuvant Treatment for Breast Cancer J. Clin. Oncol., February 1, 2009; 27(4): 526 - 534. [Abstract] [Full Text] [PDF]

				E. Rivera, J. Lee, and A. Davies Clinical Development of Ixabepilone and Other Epothilones in Patients with Advanced Solid Tumors Oncologist, December 1, 2008; 13(12): 1207 - 1223. [Abstract] [Full Text] [PDF]

				J.-Y. Pierga, F.-C. Bidard, C. Mathiot, E. Brain, S. Delaloge, S. Giachetti, P. de Cremoux, R. Salmon, A. Vincent-Salomon, and M. Marty Circulating Tumor Cell Detection Predicts Early Metastatic Relapse After Neoadjuvant Chemotherapy in Large Operable and Locally Advanced Breast Cancer in a Phase II Randomized Trial Clin. Cancer Res., November 1, 2008; 14(21): 7004 - 7010. [Abstract] [Full Text] [PDF]

				A. Berruti, M. P. Brizzi, D. Generali, M. Ardine, L. Dogliotti, P. Bruzzi, and A. Bottini Presurgical Systemic Treatment of Nonmetastatic Breast Cancer: Facts and Open Questions Oncologist, November 1, 2008; 13(11): 1137 - 1148. [Abstract] [Full Text] [PDF]

				M.-L. W. Ah-See, A. Makris, N. J. Taylor, M. Harrison, P. I. Richman, R. J. Burcombe, J. J. Stirling, J. A. d'Arcy, D. J. Collins, M. R. Pittam, et al. Early Changes in Functional Dynamic Magnetic Resonance Imaging Predict for Pathologic Response to Neoadjuvant Chemotherapy in Primary Breast Cancer Clin. Cancer Res., October 15, 2008; 14(20): 6580 - 6589. [Abstract] [Full Text] [PDF]

				L. Pusztai, K. Broglio, F. Andre, W. F. Symmans, K. R. Hess, and G. N. Hortobagyi Effect of Molecular Disease Subsets on Disease-Free Survival in Randomized Adjuvant Chemotherapy Trials for Estrogen Receptor-Positive Breast Cancer J. Clin. Oncol., October 1, 2008; 26(28): 4679 - 4683. [Abstract] [Full Text] [PDF]

				F. Andre, K. Broglio, H. Roche, M. Martin, J. R. Mackey, F. Penault-Llorca, G. N. Hortobagyi, and L. Pusztai Estrogen Receptor Expression and Efficacy of Docetaxel-Containing Adjuvant Chemotherapy in Patients With Node-Positive Breast Cancer: Results From a Pooled Analysis J. Clin. Oncol., June 1, 2008; 26(16): 2636 - 2643. [Abstract] [Full Text] [PDF]

				F. J. Esteva and G. N. Hortobagyi Can Early Response Assessment Guide Neoadjuvant Chemotherapy in Early-Stage Breast Cancer? J Natl Cancer Inst, April 16, 2008; 100(8): 521 - 523. [Full Text] [PDF]

				H. D. Bear Measuring Circulating Tumor Cells As a Surrogate End Point for Adjuvant Therapy of Breast Cancer: What Do They Mean and What Should We Do About Them? J. Clin. Oncol., March 10, 2008; 26(8): 1195 - 1197. [Full Text] [PDF]

				P. Rastogi, S. J. Anderson, H. D. Bear, C. E. Geyer, M. S. Kahlenberg, A. Robidoux, R. G. Margolese, J. L. Hoehn, V. G. Vogel, S. R. Dakhil, et al. Preoperative Chemotherapy: Updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27 J. Clin. Oncol., February 10, 2008; 26(5): 778 - 785. [Abstract] [Full Text] [PDF]

				T. A. Buchholz, C. D. Lehman, J. R. Harris, B. A. Pockaj, N. Khouri, N. F. Hylton, M. J. Miller, T. Whelan, L. J. Pierce, L. J. Esserman, et al. Statement of the Science Concerning Locoregional Treatments After Preoperative Chemotherapy for Breast Cancer: A National Cancer Institute Conference J. Clin. Oncol., February 10, 2008; 26(5): 791 - 797. [Abstract] [Full Text] [PDF]

				A. C. Wolff, D. Berry, L. A. Carey, M. Colleoni, M. Dowsett, M. Ellis, J. E. Garber, D. Mankoff, S. Paik, L. Pusztai, et al. Research Issues Affecting Preoperative Systemic Therapy for Operable Breast Cancer J. Clin. Oncol., February 10, 2008; 26(5): 806 - 813. [Abstract] [Full Text] [PDF]

				C. Hudis and S. Modi Preoperative Chemotherapy for Breast Cancer: Miracle or Mirage? JAMA, December 12, 2007; 298(22): 2665 - 2667. [Full Text] [PDF]

				R. M. Layman, D. G. Thomas, K. A. Griffith, J. B. Smerage, M. A. Helvie, M. A. Roubidoux, K. M. Diehl, L. A. Newman, M. S. Sabel, J. A. Hayman, et al. Neoadjuvant Docetaxel and Capecitabine and the Use of Thymidine Phosphorylase as a Predictive Biomarker in Breast Cancer Clin. Cancer Res., July 15, 2007; 13(14): 4092 - 4097. [Abstract] [Full Text] [PDF]

				C. Mazouni, F. Peintinger, S. Wan-Kau, F. Andre, A. M. Gonzalez-Angulo, W. F. Symmans, F. Meric-Bernstam, V. Valero, G. N. Hortobagyi, and L. Pusztai Residual Ductal Carcinoma In Situ in Patients With Complete Eradication of Invasive Breast Cancer After Neoadjuvant Chemotherapy Does Not Adversely Affect Patient Outcome J. Clin. Oncol., July 1, 2007; 25(19): 2650 - 2655. [Abstract] [Full Text] [PDF]

				C Natoli, E Cianchetti, N Tinari, D Angelucci, A Grassadonia, M Zilli, C Ficorella, E Ricevuto, S Grossi, M De Tursi, et al. A phase II study of dose-dense epirubicin plus cyclophosphamide followed by docetaxel plus capecitabine and pegfilgrastim support as preoperative therapy for patients with stage II, IIIA breast cancer Ann. Onc., June 1, 2007; 18(6): 1015 - 1020. [Abstract] [Full Text] [PDF]

				C Mazouni, S-W Kau, D Frye, F Andre, H. Kuerer, T. Buchholz, W. Symmans, K Anderson, K. Hess, A. Gonzalez-Angulo, et al. Inclusion of taxanes, particularly weekly paclitaxel, in preoperative chemotherapy improves pathologic complete response rate in estrogen receptor-positive breast cancers Ann. Onc., May 1, 2007; 18(5): 874 - 880. [Abstract] [Full Text] [PDF]

				S. A. Limentani, A. M. Brufsky, J. K. Erban, M. Jahanzeb, and D. Lewis Phase II Study of Neoadjuvant Docetaxel, Vinorelbine, and Trastuzumab Followed by Surgery and Adjuvant Doxorubicin Plus Cyclophosphamide in Women With Human Epidermal Growth Factor Receptor 2-Overexpressing Locally Advanced Breast Cancer J. Clin. Oncol., April 1, 2007; 25(10): 1232 - 1238. [Abstract] [Full Text] [PDF]

				M. Extermann More Thoughts on the Reporting of Adverse Events in Cancer Clinical Trials J. Clin. Oncol., March 1, 2007; 25(7): 918 - 918. [Full Text] [PDF]

				O. Scharf and A. D. Colevas In Reply J. Clin. Oncol., March 1, 2007; 25(7): 918 - 919. [Full Text] [PDF]

				C. Shimizu, M. Ando, T. Kouno, N. Katsumata, and Y. Fujiwara Current Trends and Controversies over Pre-operative Chemotherapy for Women with Operable Breast Cancer Jpn. J. Clin. Oncol., January 3, 2007; (2007) hyl122v1. [Abstract] [Full Text] [PDF]

				P Piedbois, D Serin, F Priou, P Laplaige, S Greget, E Angellier, E Teissier, J-F Berdah, M Fabbro, B Valenza, et al. Dose-dense adjuvant chemotherapy in node-positive breast cancer: docetaxel followed by epirubicin/cyclophosphamide (T/EC), or the reverse sequence (EC/T), every 2 weeks, versus docetaxel, epirubicin and cyclophosphamide (TEC) every 3 weeks. AERO B03 randomized phase II study Ann. Onc., January 1, 2007; 18(1): 52 - 57. [Abstract] [Full Text] [PDF]

				J. A. Sparano, S. Moulder, A. Kazi, L. Vahdat, T. Li, C. Pellegrino, P. Munster, M. Malafa, D. Lee, S. Hoschander, et al. Targeted Inhibition of Farnesyltransferase in Locally Advanced Breast Cancer: A Phase I and II Trial of Tipifarnib Plus Dose-Dense Doxorubicin and Cyclophosphamide J. Clin. Oncol., July 1, 2006; 24(19): 3013 - 3018. [Abstract] [Full Text] [PDF]

				C Montagut, I Tusquets, B Ferrer, J M Corominas, B Bellosillo, C Campas, M Suarez, X Fabregat, E Campo, P Gascon, et al. Activation of nuclear factor-{kappa} B is linked to resistance to neoadjuvant chemotherapy in breast cancer patients. Endocr. Relat. Cancer, June 1, 2006; 13(2): 607 - 616. [Abstract] [Full Text] [PDF]

				H. D. Bear, S. Anderson, R. E. Smith, C. E. Geyer Jr, E. P. Mamounas, B. Fisher, A. M. Brown, A. Robidoux, R. Margolese, M. S. Kahlenberg, et al. Sequential Preoperative or Postoperative Docetaxel Added to Preoperative Doxorubicin Plus Cyclophosphamide for Operable Breast Cancer: National Surgical Adjuvant Breast and Bowel Project Protocol B-27 J. Clin. Oncol., May 1, 2006; 24(13): 2019 - 2027. [Abstract] [Full Text] [PDF]

				O. Thuerigen, A. Schneeweiss, G. Toedt, P. Warnat, M. Hahn, H. Kramer, B. Brors, C. Rudlowski, A. Benner, F. Schuetz, et al. Gene Expression Signature Predicting Pathologic Complete Response With Gemcitabine, Epirubicin, and Docetaxel in Primary Breast Cancer J. Clin. Oncol., April 20, 2006; 24(12): 1839 - 1845. [Abstract] [Full Text] [PDF]

				M. Kaufmann, G. N. Hortobagyi, A. Goldhirsch, S. Scholl, A. Makris, P. Valagussa, J.-U. Blohmer, W. Eiermann, R. Jackesz, W. Jonat, et al. Recommendations From an International Expert Panel on the Use of Neoadjuvant (Primary) Systemic Treatment of Operable Breast Cancer: An Update J. Clin. Oncol., April 20, 2006; 24(12): 1940 - 1949. [Abstract] [Full Text] [PDF]

				J. Hurley, P. Doliny, I. Reis, O. Silva, C. Gomez-Fernandez, P. Velez, G. Pauletti, J. E. Powell, M. D. Pegram, and D. J. Slamon Docetaxel, Cisplatin, and Trastuzumab As Primary Systemic Therapy for Human Epidermal Growth Factor Receptor 2-Positive Locally Advanced Breast Cancer J. Clin. Oncol., April 20, 2006; 24(12): 1831 - 1838. [Abstract] [Full Text] [PDF]

				V. Guarneri, K. Broglio, S.-W. Kau, M. Cristofanilli, A. U. Buzdar, V. Valero, T. Buchholz, F. Meric, L. Middleton, G. N. Hortobagyi, et al. Prognostic Value of Pathologic Complete Response After Primary Chemotherapy in Relation to Hormone Receptor Status and Other Factors J. Clin. Oncol., March 1, 2006; 24(7): 1037 - 1044. [Abstract] [Full Text] [PDF]

				A. B. Chakravarthy, M. C. Kelley, B. McLaren, C. I. Truica, D. Billheimer, I. A. Mayer, A. M. Grau, D. H. Johnson, J. F. Simpson, R. D. Beauchamp, et al. Neoadjuvant Concurrent Paclitaxel and Radiation in Stage II/III Breast Cancer Clin. Cancer Res., March 1, 2006; 12(5): 1570 - 1576. [Abstract] [Full Text] [PDF]

				B. T. Hennessy, G. N. Hortobagyi, R. Rouzier, H. Kuerer, N. Sneige, A. U. Buzdar, S. W. Kau, B. Fornage, A. Sahin, K. Broglio, et al. Outcome After Pathologic Complete Eradication of Cytologically Proven Breast Cancer Axillary Node Metastases Following Primary Chemotherapy J. Clin. Oncol., December 20, 2005; 23(36): 9304 - 9311. [Abstract] [Full Text] [PDF]

				L. Gianni, J. Baselga, W. Eiermann, V. Guillem Porta, V. Semiglazov, A. Lluch, M. Zambetti, D. Sabadell, G. Raab, A. Llombart Cussac, et al. Feasibility and Tolerability of Sequential Doxorubicin/Paclitaxel Followed by Cyclophosphamide, Methotrexate, and Fluorouracil and Its Effects on Tumor Response as Preoperative Therapy Clin. Cancer Res., December 15, 2005; 11(24): 8715 - 8721. [Abstract] [Full Text] [PDF]

				S. J. Kim, Y. Miyoshi, T. Taguchi, Y. Tamaki, H. Nakamura, J. Yodoi, K. Kato, and S. Noguchi High Thioredoxin Expression Is Associated with Resistance to Docetaxel in Primary Breast Cancer Clin. Cancer Res., December 1, 2005; 11(23): 8425 - 8430. [Abstract] [Full Text] [PDF]

				E. G. C. Brain, T. Bachelot, and D. Serin Life-threatening Complications From Doxorubicin-Docetaxel Chemotherapy for Breast Cancer--Reply JAMA, November 2, 2005; 294(17): 2166 - 2167. [Full Text] [PDF]

				A. Berruti, D. Generali, M. P. Brizzi, M. Ardine, L. Dogliotti, and A. Bottini Is Pathologic Complete Response a Valid Surrogate Parameter of Treatment Efficacy in HER2 Positive Breast Cancer Patients Undergoing Primary Chemotherapy Plus Trastuzamab? J. Clin. Oncol., November 1, 2005; 23(31): 8130 - 8131. [Full Text] [PDF]

				A. U. Buzdar, K. K. Hunt, D. Berry, and G. N. Hortobagyi In Reply: J. Clin. Oncol., November 1, 2005; 23(31): 8131 - 8132. [Full Text] [PDF]

				Y. W. Moon, S. Y. Rha, H. C. Jeung, W. I. Yang, C. O. Suh, and H. C. Chung Neoadjuvant chemotherapy with infusional 5-fluorouracil, adriamycin and cyclophosphamide (iFAC) in locally advanced breast cancer: an early response predicts good prognosis Ann. Onc., November 1, 2005; 16(11): 1778 - 1785. [Abstract] [Full Text] [PDF]

				M. Cianfrocca and W. J. Gradishar Controversies in the Therapy of Early Stage Breast Cancer Oncologist, November 1, 2005; 10(10): 766 - 779. [Abstract] [Full Text] [PDF]

				P. Schmid, J. Krocker, C. Jehn, K. Michniewicz, S. Lehenbauer-Dehm, H. Eggemann, V. Heilmann, S. Kummel, C. O. Schulz, A. Dieing, et al. Primary chemotherapy with gemcitabine as prolonged infusion, non-pegylated liposomal doxorubicin and docetaxel in patients with early breast cancer: final results of a phase II trial Ann. Onc., October 1, 2005; 16(10): 1624 - 1631. [Abstract] [Full Text] [PDF]

				E. P. Mamounas Can We Approach Zero Relapse in Breast Cancer? Oncologist, October 1, 2005; 10(suppl_2): 9 - 17. [Abstract] [Full Text] [PDF]

				M. Cristofanilli, A. Gonzalez-Angulo, and G. Hortobagyi In Reply: J. Clin. Oncol., September 20, 2005; 23(27): 6796 - 6797. [Full Text] [PDF]

				M. C. Green, A. U. Buzdar, T. Smith, N. K. Ibrahim, V. Valero, M. F. Rosales, M. Cristofanilli, D. J. Booser, L. Pusztai, E. Rivera, et al. Weekly Paclitaxel Improves Pathologic Complete Remission in Operable Breast Cancer When Compared With Paclitaxel Once Every 3 Weeks J. Clin. Oncol., September 1, 2005; 23(25): 5983 - 5992. [Abstract] [Full Text] [PDF]

				H. Bonnefoi 'Small' randomised neo-adjuvant chemotherapy trials in breast cancer reporting on pathological response: more harm than good? Ann. Onc., September 1, 2005; 16(9): 1407 - 1410. [Full Text] [PDF]

				W. J. Gradishar, S. B. Wedam, M. Jahanzeb, J. Erban, S. A. Limentani, K.-T. Tsai, S. R. Olsen, and S. M. Swain Neoadjuvant docetaxel followed by adjuvant doxorubicin and cyclophosphamide in patients with stage III breast cancer Ann. Onc., August 1, 2005; 16(8): 1297 - 1304. [Abstract] [Full Text] [PDF]

				G. Frasci, G. D'Aiuto, P. Comella, R. Thomas, G. Botti, M. Di Bonito, M. D'Aiuto, G. Romano, M. R. Rubulotta, G. Comella, et al. A 2-month cisplatin-epirubicin-paclitaxel (PET) weekly combination as primary systemic therapy for large operable breast cancer: a phase II study Ann. Onc., August 1, 2005; 16(8): 1268 - 1275. [Abstract] [Full Text] [PDF]

				M. Martin, T. Pienkowski, J. Mackey, M. Pawlicki, J.-P. Guastalla, C. Weaver, E. Tomiak, T. Al-Tweigeri, L. Chap, E. Juhos, et al. Adjuvant Docetaxel for Node-Positive Breast Cancer N. Engl. J. Med., June 2, 2005; 352(22): 2302 - 2313. [Abstract] [Full Text] [PDF]

				A. M. Gonzalez-Angulo, P. Morandi, and M. Cristofanilli Inflammatory Breast Cancer and High-Dose Chemotherapy: Back to the Past J. Clin. Oncol., June 1, 2005; 23(16): 3859 - 3860. [Full Text] [PDF]

				E. G. C. Brain, T. Bachelot, D. Serin, S. Kirscher, Y. Graic, J.-C. Eymard, J.-M. Extra, M. Combe, E. Fourme, C. Nogues, et al. Life-Threatening Sepsis Associated With Adjuvant Doxorubicin Plus Docetaxel for Intermediate-Risk Breast Cancer JAMA, May 18, 2005; 293(19): 2367 - 2371. [Abstract] [Full Text] [PDF]

				T.R. J. Evans, A. Yellowlees, E. Foster, H. Earl, D. A. Cameron, A. W. Hutcheon, R. E. Coleman, T. Perren, C. J. Gallagher, M. Quigley, et al. Phase III Randomized Trial of Doxorubicin and Docetaxel Versus Doxorubicin and Cyclophosphamide As Primary Medical Therapy in Women With Breast Cancer: An Anglo-Celtic Cooperative Oncology Group Study J. Clin. Oncol., May 1, 2005; 23(13): 2988 - 2995. [Abstract] [Full Text] [PDF]

				G. von Minckwitz, G. Raab, A. Caputo, M. Schutte, J. Hilfrich, J. U. Blohmer, B. Gerber, S. D. Costa, E. Merkle, H. Eidtmann, et al. Doxorubicin With Cyclophosphamide Followed by Docetaxel Every 21 Days Compared With Doxorubicin and Docetaxel Every 14 Days As Preoperative Treatment in Operable Breast Cancer: The GEPARDUO Study of the German Breast Group J. Clin. Oncol., April 20, 2005; 23(12): 2676 - 2685. [Abstract] [Full Text] [PDF]

				E. P. Mamounas, A. Brown, S. Anderson, R. Smith, T. Julian, B. Miller, H. D. Bear, C. B. Caldwell, A. P. Walker, W. M. Mikkelson, et al. Sentinel Node Biopsy After Neoadjuvant Chemotherapy in Breast Cancer: Results From National Surgical Adjuvant Breast and Bowel Project Protocol B-27 J. Clin. Oncol., April 20, 2005; 23(12): 2694 - 2702. [Abstract] [Full Text] [PDF]

				E. P. Mamounas Continuing Evolution in Breast Cancer Surgical Management J. Clin. Oncol., March 10, 2005; 23(8): 1603 - 1606. [Full Text] [PDF]

				A. Hamilton and G. Hortobagyi Chemotherapy: What Progress in the Last 5 Years? J. Clin. Oncol., March 10, 2005; 23(8): 1760 - 1775. [Full Text] [PDF]

				C. L. Vogel, M. Z. Wojtukiewicz, R. R. Carroll, S. A. Tjulandin, L. J. Barajas-Figueroa, B. L. Wiens, T. A. Neumann, and L. S. Schwartzberg First and Subsequent Cycle Use of Pegfilgrastim Prevents Febrile Neutropenia in Patients With Breast Cancer: A Multicenter, Double-Blind, Placebo-Controlled Phase III Study J. Clin. Oncol., February 20, 2005; 23(6): 1178 - 1184. [Abstract] [Full Text] [PDF]

				N. E. Davidson and M. Morrow Sometimes a Great Notion--An Assessment of Neoadjuvant Systemic Therapy for Breast Cancer J Natl Cancer Inst, February 2, 2005; 97(3): 159 - 161. [Full Text] [PDF]

				D. Mauri, N. Pavlidis, and J. P. A. Ioannidis Neoadjuvant Versus Adjuvant Systemic Treatment in Breast Cancer: A Meta-Analysis J Natl Cancer Inst, February 2, 2005; 97(3): 188 - 194. [Abstract] [Full Text] [PDF]

				K. Iwao-Koizumi, R. Matoba, N. Ueno, S. J. Kim, A. Ando, Y. Miyoshi, E. Maeda, S. Noguchi, and K. Kato Prediction of Docetaxel Response in Human Breast Cancer by Gene Expression Profiling J. Clin. Oncol., January 20, 2005; 23(3): 422 - 431. [Abstract] [Full Text] [PDF]

				M. Cristofanilli, A. Gonzalez-Angulo, N. Sneige, S.-W. Kau, K. Broglio, R. L. Theriault, V. Valero, A. U. Buzdar, H. Kuerer, T. A. Buccholz, et al. Invasive Lobular Carcinoma Classic Type: Response to Primary Chemotherapy and Survival Outcomes J. Clin. Oncol., January 1, 2005; 23(1): 41 - 48. [Abstract] [Full Text] [PDF]

				G. von Minckwitz, J.-U. Blohmer, G. Raab, A. Lohr, B. Gerber, G. Heinrich, H. Eidtmann, M. Kaufmann, J. Hilfrich, C. Jackisch, et al. In vivo chemosensitivity-adapted preoperative chemotherapy in patients with early-stage breast cancer: the GEPARTRIO pilot study Ann. Onc., January 1, 2005; 16(1): 56 - 63. [Abstract] [Full Text] [PDF]

				V. Dieras, P. Fumoleau, G. Romieu, M. Tubiana-Hulin, M. Namer, L. Mauriac, J.-P. Guastalla, E. Pujade-Lauraine, P. Kerbrat, P. Maillart, et al. Randomized Parallel Study of Doxorubicin Plus Paclitaxel and Doxorubicin Plus Cyclophosphamide As Neoadjuvant Treatment of Patients With Breast Cancer J. Clin. Oncol., December 15, 2004; 22(24): 4958 - 4965. [Abstract] [Full Text] [PDF]

				K. S. Albain Adjuvant Chemotherapy for Lymph Node-Negative, Estrogen Receptor-Negative Breast Cancer: A Tale of Three Trials J Natl Cancer Inst, December 15, 2004; 96(24): 1801 - 1804. [Full Text] [PDF]

				P. F. Lebowitz, J. Eng-Wong, S. M. Swain, A. Berman, M. J. Merino, C. K. Chow, D. Venzon, F. Zia, D. Danforth, E. Liu, et al. A Phase II Trial of Neoadjuvant Docetaxel and Capecitabine for Locally Advanced Breast Cancer Clin. Cancer Res., October 15, 2004; 10(20): 6764 - 6769. [Abstract] [Full Text] [PDF]

				M. Colleoni, G. Viale, D. Zahrieh, G. Pruneri, O. Gentilini, P. Veronesi, R. D. Gelber, G. Curigliano, R. Torrisi, A. Luini, et al. Chemotherapy Is More Effective in Patients with Breast Cancer Not Expressing Steroid Hormone Receptors: A Study of Preoperative Treatment Clin. Cancer Res., October 1, 2004; 10(19): 6622 - 6628. [Abstract] [Full Text] [PDF]

				S. Verma, M. Clemons, B. Fitzgerald, and O. Freedman Treatment of locally advanced breast cancer Can. Med. Assoc. J., August 3, 2004; 171(3): 219 - 219. [Full Text] [PDF]

				T. Shenkier, M. Levine, and I. Olivotto Treatment of locally advanced breast cancer Can. Med. Assoc. J., August 3, 2004; 171(3): 221 - 222. [Full Text] [PDF]

				M. S. Mano and A. Awada Primary chemotherapy for breast cancer: the evidence and the future Ann. Onc., August 1, 2004; 15(8): 1161 - 1171. [Abstract] [Full Text] [PDF]

				E. Thomas, F. A. Holmes, T. L. Smith, A. U. Buzdar, D. K. Frye, G. Fraschini, S. E. Singletary, R. L. Theriault, M. D. McNeese, F. Ames, et al. The Use of Alternate, Non-Cross-Resistant Adjuvant Chemotherapy on the Basis of Pathologic Response to a Neoadjuvant Doxorubicin-Based Regimen in Women With Operable Breast Cancer: Long-Term Results From a Prospective Randomized Trial J. Clin. Oncol., June 15, 2004; 22(12): 2294 - 2302. [Abstract] [Full Text] [PDF]

				J. Crown, M. O'Leary, and W.-S. Ooi Docetaxel and Paclitaxel in the Treatment of Breast Cancer: A Review of Clinical Experience Oncologist, June 2, 2004; 9(suppl_2): 24 - 32. [Abstract] [Full Text] [PDF]

				L. G. Estevez and W. J. Gradishar Evidence-Based Use of Neoadjuvant Taxane in Operable and Inoperable Breast Cancer Clin. Cancer Res., May 15, 2004; 10(10): 3249 - 3261. [Abstract] [Full Text] [PDF]

				N. Shahab and S. Haider Is Docetaxel Now an Essential Component of Neoadjuvant Breast Chemotherapy? J. Clin. Oncol., May 1, 2004; 22(9): 1766 - 1766. [Full Text] [PDF]

				H. D. Bear In Reply: J. Clin. Oncol., May 1, 2004; 22(9): 1766 - 1767. [Full Text] [PDF]

				G. W. Sledge Jr Preoperative Chemotherapy for Breast Cancer: Lessons Learned and Future Prospects J. Clin. Oncol., December 15, 2003; 21(24): 4481 - 4482. [Full Text] [PDF]