Journal of Clinical Oncology, Vol 22, No 7 (April 1), 2004: pp. 1209-1214
© 2004 American Society of Clinical Oncology.
DOI: 10.1200/JCO.2004.11.037
Survival of Patients With Advanced Colorectal Cancer Improves With the Availability of Fluorouracil-Leucovorin, Irinotecan, and Oxaliplatin in the Course of Treatment
Axel Grothey,
Daniel Sargent,
Richard M. Goldberg,
Hans-Joachim Schmoll
From the Divisions of Medical Oncology and Biostatistics, Mayo Clinic, Rochester, MN; Division of Oncology, University of North Carolina, Chapel Hill, NC; and Department of Hematology/Oncology, University of Halle, Halle, Germany
Address reprint requests to Axel Grothey, MD, Division of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN 55905; e-mail: grothey.axel{at}mayo.edu
PURPOSE: Fluorouracil (FU)-leucovorin (LV), irinotecan, and oxaliplatin administered alone or in combination have proven effective in the treatment of advanced colorectal cancer (CRC). Combination protocols using FU-LV with either irinotecan or oxaliplatin are currently regarded as standard first-line therapies in this disease. However, the importance of the availability of all three active cytotoxic agents, FU-LV, irinotecan, and oxaliplatin, on overall survival (OS) has not yet been evaluated.
MATERIALS AND METHODS: We analyzed data from seven recently published phase III trials in advanced CRC to correlate the percentage of patients receiving second-line therapy and the percentage of patients receiving all three agents with the reported median OS, using a weighted analysis.
RESULTS: The reported median OS is significantly correlated with the percentage of patients who received all three drugs in the course of their disease (P = .0008) but not with the percentage of patients who received any second-line therapy (P = .19). In addition, the use of combination protocols as first-line therapy was associated with a significant improvement in median survival of 3.5 months (95% CI, 1.27 to 5.73 months; P = .0083).
CONCLUSION: Our results support the strategy of making these three active drugs available to all patients with advanced CRC who are candidates for such therapy to maximize OS. In addition, our findings suggest that, with the availability of effective salvage options, OS should no longer be regarded as the most appropriate end point by which to assess the efficacy of a palliative first-line treatment in CRC.
Supported in part by Public Health Services grant No. CA-25224 from the National Cancer Institute to the Mayo Clinic in support of the North Central Cancer Treatment Group.
Authors' disclosures of potential conflicts of interest are found at the end of this article.

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 |

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|
 |
|

|
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|
 |
 
R. M. Goldberg, D. J. Sargent, R. F. Morton, E. Green, H. K. Sanoff, H. McLeod, and J. Buckner
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Oncologist,
October 1, 2009;
14(10):
970 - 978.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
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|
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A. Grothey
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Therapeutic Advances in Medical Oncology,
September 1, 2009;
1(2):
55 - 68.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Rosati, S. Cordio, R. Bordonaro, G. Caputo, G. Novello, G. Reggiardo, and L. Manzione
Capecitabine in combination with oxaliplatin or irinotecan in elderly patients with advanced colorectal cancer: results of a randomized phase II study
Ann. Onc.,
August 27, 2009;
(2009)
mdp359v1.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Qvortrup, B. V. Jensen, T. Fokstuen, S. E. Nielsen, N. Keldsen, B. Glimelius, B. Bjerregaard, J. Mejer, F. O. Larsen, and P. Pfeiffer
A randomized study comparing short-time infusion of oxaliplatin in combination with capecitabine XELOX30 and chronomodulated XELOX30 as first-line therapy in patients with advanced colorectal cancer
Ann. Onc.,
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(2009)
mdp272v1.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. H. Schiller and S. S. Ramalingam
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J. Clin. Oncol.,
July 10, 2009;
27(20):
3265 - 3267.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. J. Lim, S. Gill, C. Speers, B. Melosky, J. Barnett, C. Fitzgerald, S. O'Reilly, and H. Kennecke
Impact of Irinotecan and Oxaliplatin on Overall Survival in Patients With Metastatic Colorectal Cancer: A Population-Based Study
J. Oncol. Pract,
July 1, 2009;
5(4):
153 - 158.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. P. Kim, D. J. Sargent, M. R. Mahoney, K. M. Rowland Jr, P. A. Philip, E. Mitchell, A. P. Mathews, T. R. Fitch, R. M. Goldberg, S. R. Alberts, et al.
Phase III Noninferiority Trial Comparing Irinotecan With Oxaliplatin, Fluorouracil, and Leucovorin in Patients With Advanced Colorectal Carcinoma Previously Treated With Fluorouracil: N9841
J. Clin. Oncol.,
June 10, 2009;
27(17):
2848 - 2854.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Inoue, Y. Toiyama, K. Tanaka, C. Miki, and M. Kusunoki
A Comprehensive Comparative Study on the Characteristics of Colorectal Cancer Chemotherapy
Jpn. J. Clin. Oncol.,
June 1, 2009;
39(6):
367 - 375.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. Damjanov
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Oncologist,
June 1, 2009;
14(6):
578 - 579.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Lurje, P. C. Manegold, Y. Ning, A. Pohl, W. Zhang, and H.-J. Lenz
Thymidylate synthase gene variations: predictive and prognostic markers
Mol. Cancer Ther.,
May 1, 2009;
8(5):
1000 - 1007.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H.-J. Au, C. S. Karapetis, C. J. O'Callaghan, D. Tu, M. J. Moore, J. R. Zalcberg, H. Kennecke, J. D. Shapiro, S. Koski, N. Pavlakis, et al.
Health-Related Quality of Life in Patients With Advanced Colorectal Cancer Treated With Cetuximab: Overall and KRAS-Specific Results of the NCIC CTG and AGITG CO.17 Trial
J. Clin. Oncol.,
April 10, 2009;
27(11):
1822 - 1828.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. L. Barros Costa
Review Article: Targeted Therapy: Comprehensive Review
American Journal of Hospice and Palliative Medicine,
April 1, 2009;
26(2):
137 - 146.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
N. Rama, A. Monteiro, J. E. Bernardo, L. Eugenio, and M. J. Antunes
Lung metastases from colorectal cancer: surgical resection and prognostic factors
Eur. J. Cardiothorac. Surg.,
March 1, 2009;
35(3):
444 - 449.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. Cunningham, B. Sirohi, A. Pluzanska, B. Utracka-Hutka, J. Zaluski, R. Glynne-Jones, P. Koralewski, J. Bridgewater, P. Mainwaring, H. Wasan, et al.
Two different first-line 5-fluorouracil regimens with or without oxaliplatin in patients with metastatic colorectal cancer
Ann. Onc.,
February 1, 2009;
20(2):
244 - 250.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Grothey
Optimized Treatment of Metastatic Colorectal Cancer
ASCO Educational Book,
January 1, 2009;
2009(1):
209 - 211.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. Nakashima, S. Hironaka, N. Boku, Y. Onozawa, A. Fukutomi, K. Yamazaki, H. Yasui, K. Taku, T. Kojima, and N. Machida
Irinotecan Plus Cisplatin Therapy and S-1 Plus Cisplatin Therapy for Advanced or Recurrent Gastric Cancer in a Single Institution
Jpn. J. Clin. Oncol.,
December 1, 2008;
38(12):
810 - 815.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Grothey, M. M. Sugrue, D. M. Purdie, W. Dong, D. Sargent, E. Hedrick, and M. Kozloff
Bevacizumab Beyond First Progression Is Associated With Prolonged Overall Survival in Metastatic Colorectal Cancer: Results From a Large Observational Cohort Study (BRiTE)
J. Clin. Oncol.,
November 20, 2008;
26(33):
5326 - 5334.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. M. Ellis and D. G. Haller
Bevacizumab Beyond Progression: Does This Make Sense?
J. Clin. Oncol.,
November 20, 2008;
26(33):
5313 - 5315.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. J. Poston, J. Figueras, F. Giuliante, G. Nuzzo, A. F. Sobrero, J.-F. Gigot, B. Nordlinger, R. Adam, T. Gruenberger, M. A. Choti, et al.
Urgent Need for a New Staging System in Advanced Colorectal Cancer
J. Clin. Oncol.,
October 10, 2008;
26(29):
4828 - 4833.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Grothey and D. J. Sargent
New Lessons From "Old" Chemotherapy in Colorectal Cancer
J. Clin. Oncol.,
October 1, 2008;
26(28):
4532 - 4534.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. G. Haller, M. L. Rothenberg, A. O. Wong, P. M. Koralewski, W. H. Miller Jr, G. Bodoky, N. Habboubi, C. Garay, and L. O. Olivatto
Oxaliplatin Plus Irinotecan Compared With Irinotecan Alone as Second-Line Treatment After Single-Agent Fluoropyrimidine Therapy for Metastatic Colorectal Carcinoma
J. Clin. Oncol.,
October 1, 2008;
26(28):
4544 - 4550.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Grothey
Surrogate endpoints for overall survival in early colorectal cancer from the clinician's perspective
Statistical Methods in Medical Research,
October 1, 2008;
17(5):
529 - 535.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
N. Machida, T. Yoshino, N. Boku, S. Hironaka, Y. Onozawa, A. Fukutomi, K. Yamazaki, H. Yasui, K. Taku, and M. Asaka
Impact of Baseline Sum of Longest Diameter in Target Lesions by RECIST on Survival of Patients with Metastatic Colorectal Cancer
Jpn. J. Clin. Oncol.,
October 1, 2008;
38(10):
689 - 694.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. Ward, J. A. Guthrie, M. B. Sheridan, S. Boyes, J. T. Smith, D. Wilson, J. I. Wyatt, D. Treanor, and P. J. Robinson
Sinusoidal Obstructive Syndrome Diagnosed With Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging in Patients With Chemotherapy-Treated Colorectal Liver Metastases
J. Clin. Oncol.,
September 10, 2008;
26(26):
4304 - 4310.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. J. Cohen, C. J.A. Punt, N. Iannotti, B. H. Saidman, K. D. Sabbath, N. Y. Gabrail, J. Picus, M. Morse, E. Mitchell, M. C. Miller, et al.
Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer
J. Clin. Oncol.,
July 1, 2008;
26(19):
3213 - 3221.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Qvortrup, M. Yilmaz, D. Ogreid, A. Berglund, L. Balteskard, J. Ploen, T. Fokstuen, H. Starkhammar, H. Sorbye, K. Tveit, et al.
Chronomodulated capecitabine in combination with short-time oxaliplatin: a Nordic phase II study of second-line therapy in patients with metastatic colorectal cancer after failure to irinotecan and 5-flourouracil
Ann. Onc.,
June 1, 2008;
19(6):
1154 - 1159.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. Pfeiffer, D. Nielsen, J. Bjerregaard, C. Qvortrup, M. Yilmaz, and B. Jensen
Biweekly cetuximab and irinotecan as third-line therapy in patients with advanced colorectal cancer after failure to irinotecan, oxaliplatin and 5-fluorouracil
Ann. Onc.,
June 1, 2008;
19(6):
1141 - 1145.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. R. Hecht
Current and emerging therapies for metastatic colorectal cancer: Applying research findings to clinical practice
Am. J. Health Syst. Pharm.,
June 1, 2008;
65(11_Supplement_4):
S15 - S21.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. F. Sobrero, J. Maurel, L. Fehrenbacher, W. Scheithauer, Y. A. Abubakr, M. P. Lutz, M. E. Vega-Villegas, C. Eng, E. U. Steinhauer, J. Prausova, et al.
EPIC: Phase III Trial of Cetuximab Plus Irinotecan After Fluoropyrimidine and Oxaliplatin Failure in Patients With Metastatic Colorectal Cancer
J. Clin. Oncol.,
May 10, 2008;
26(14):
2311 - 2319.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B. Gruenberger, D. Tamandl, J. Schueller, W. Scheithauer, C. Zielinski, F. Herbst, and T. Gruenberger
Bevacizumab, Capecitabine, and Oxaliplatin As Neoadjuvant Therapy for Patients With Potentially Curable Metastatic Colorectal Cancer
J. Clin. Oncol.,
April 10, 2008;
26(11):
1830 - 1835.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Pessino, S. Artale, S. Sciallero, A. Guglielmi, G. Fornarini, I.C. Andreotti, S. Mammoliti, D. Comandini, F. Caprioni, E. Bennicelli, et al.
First-line single-agent cetuximab in patients with advanced colorectal cancer
Ann. Onc.,
April 1, 2008;
19(4):
711 - 716.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C.-H. Kohne, G. Folprecht, R. M. Goldberg, E. Mitry, and P. Rougier
Chemotherapy in Elderly Patients with Colorectal Cancer
Oncologist,
April 1, 2008;
13(4):
390 - 402.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Grothey, E. E. Hedrick, R. D. Mass, S. Sarkar, S. Suzuki, R. K. Ramanathan, H. I. Hurwitz, R. M. Goldberg, and D. J. Sargent
Response-Independent Survival Benefit in Metastatic Colorectal Cancer: A Comparative Analysis of N9741 and AVF2107
J. Clin. Oncol.,
January 10, 2008;
26(2):
183 - 189.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. Seki, T. Ozaki, and M. Shiina
Side-Hole Catheter Placement for Hepatic Arterial Infusion Chemotherapy in Patients with Liver Metastases from Colorectal Cancer: Long-Term Treatment and Survival Benefit
Am. J. Roentgenol.,
January 1, 2008;
190(1):
111 - 120.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Buyse, T. Burzykowski, K. Carroll, S. Michiels, D. J. Sargent, L. L. Miller, G. L. Elfring, J.-P. Pignon, and P. Piedbois
Progression-Free Survival Is a Surrogate for Survival in Advanced Colorectal Cancer
J. Clin. Oncol.,
November 20, 2007;
25(33):
5218 - 5224.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. J. Jonker, C. J. O'Callaghan, C. S. Karapetis, J. R. Zalcberg, D. Tu, H.-J. Au, S. R. Berry, M. Krahn, T. Price, R. J. Simes, et al.
Cetuximab for the Treatment of Colorectal Cancer
N. Engl. J. Med.,
November 15, 2007;
357(20):
2040 - 2048.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. A. Herbertson, S. T. Lee, N. Tebbutt, and A. M. Scott
The expanding role of PET technology in the management of patients with colorectal cancer
Ann. Onc.,
November 1, 2007;
18(11):
1774 - 1781.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. M. Bukowski, F. F. Kabbinavar, R. A. Figlin, K. Flaherty, S. Srinivas, U. Vaishampayan, H. A. Drabkin, J. Dutcher, S. Ryba, Q. Xia, et al.
Randomized Phase II Study of Erlotinib Combined With Bevacizumab Compared With Bevacizumab Alone in Metastatic Renal Cell Cancer
J. Clin. Oncol.,
October 10, 2007;
25(29):
4536 - 4541.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Porschen, H.-T. Arkenau, S. Kubicka, R. Greil, T. Seufferlein, W. Freier, A. Kretzschmar, U. Graeven, A. Grothey, A. Hinke, et al.
Phase III Study of Capecitabine Plus Oxaliplatin Compared With Fluorouracil and Leucovorin Plus Oxaliplatin in Metastatic Colorectal Cancer: A Final Report of the AIO Colorectal Study Group
J. Clin. Oncol.,
September 20, 2007;
25(27):
4217 - 4223.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. J. Mayer
Should Capecitabine Replace Infusional Fluorouracil and Leucovorin When Combined With Oxaliplatin in Metastatic Colorectal Cancer?
J. Clin. Oncol.,
September 20, 2007;
25(27):
4165 - 4167.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Yoshino, N. Boku, Y. Onozawa, S. Hironaka, A. Fukutomi, Y. Yamaguchi, N. Hasuike, K. Yamazaki, N. Machida, and H. Ono
Efficacy and Safety of an Irinotecan plus Bolus 5-Fluorouracil and L-Leucovorin Regimen for Metastatic Colorectal Cancer in Japanese Patients: Experience in a Single Institution in Japan
Jpn. J. Clin. Oncol.,
September 1, 2007;
37(9):
686 - 691.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. de Gramont, M. Buyse, J. C. Abrahantes, T. Burzykowski, E. Quinaux, A. Cervantes, A. Figer, G. Lledo, M. Flesch, L. Mineur, et al.
Reintroduction of Oxaliplatin Is Associated With Improved Survival in Advanced Colorectal Cancer
J. Clin. Oncol.,
August 1, 2007;
25(22):
3224 - 3229.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. D. Wagner, U. Wedding, O. Kuss, and K. Hoffken
Docetaxel for Advanced Gastric Cancer?
J. Clin. Oncol.,
June 10, 2007;
25(17):
2490 - 2491.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. Boku, A. Ohtsu, I. Hyodo, K. Shirao, Y. Miyata, K. Nakagawa, T. Tamura, K. Hatake, and Y. Tanigawara
Phase II Study of Oxaliplatin in Japanese Patients with Metastatic Colorectal Cancer Refractory to Fluoropyrimidines
Jpn. J. Clin. Oncol.,
June 1, 2007;
37(6):
440 - 445.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. Hiraoka, T. Kimura, C. R. Logg, C.-K. Tai, K. Haga, G. W. Lawson, and N. Kasahara
Therapeutic Efficacy of Replication-Competent Retrovirus Vector-Mediated Suicide Gene Therapy in a Multifocal Colorectal Cancer Metastasis Model
Cancer Res.,
June 1, 2007;
67(11):
5345 - 5353.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Falcone, S. Ricci, I. Brunetti, E. Pfanner, G. Allegrini, C. Barbara, L. Crino, G. Benedetti, W. Evangelista, L. Fanchini, et al.
Phase III Trial of Infusional Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan (FOLFOXIRI) Compared With Infusional Fluorouracil, Leucovorin, and Irinotecan (FOLFIRI) As First-Line Treatment for Metastatic Colorectal Cancer: The Gruppo Oncologico Nord Ovest
J. Clin. Oncol.,
May 1, 2007;
25(13):
1670 - 1676.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. J. Meropol and K. A. Schulman
Cost of Cancer Care: Issues and Implications
J. Clin. Oncol.,
January 10, 2007;
25(2):
180 - 186.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Gill, A. W. Blackstock, and R. M. Goldberg
Colorectal Cancer
Mayo Clin. Proc.,
January 1, 2007;
82(1):
114 - 129.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. M. Goldberg, M. L. Rothenberg, E. Van Cutsem, A. B. Benson III, C. D. Blanke, R. B. Diasio, A. Grothey, H.-J. Lenz, N. J. Meropol, R. K. Ramanathan, et al.
The Continuum of Care: A Paradigm for the Management of Metastatic Colorectal Cancer
Oncologist,
January 1, 2007;
12(1):
38 - 50.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Portier, D. Elias, O. Bouche, P. Rougier, J.-F. Bosset, J. Saric, J. Belghiti, P. Piedbois, R. Guimbaud, B. Nordlinger, et al.
Multicenter Randomized Trial of Adjuvant Fluorouracil and Folinic Acid Compared With Surgery Alone After Resection of Colorectal Liver Metastases: FFCD ACHBTH AURC 9002 Trial
J. Clin. Oncol.,
November 1, 2006;
24(31):
4976 - 4982.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W Ichikawa and Y Sasaki
Correlation between tumor response to first-line chemotherapy and prognosis in advanced gastric cancer patients
Ann. Onc.,
November 1, 2006;
17(11):
1665 - 1672.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. Gholam, S. Giacchetti, C. Brezault-Bonnet, M. Bouchahda, D. Hauteville, R. Adam, B. Ducot, O. Ghemard, F. Kustlinger, C. Jasmin, et al.
Chronomodulated Irinotecan, Oxaliplatin, and Leucovorin-Modulated 5-Fluorouracil as Ambulatory Salvage Therapy in Patients with Irinotecan- and Oxaliplatin-Resistant Metastatic Colorectal Cancer
Oncologist,
November 1, 2006;
11(10):
1072 - 1080.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M Koopman, N. Antonini, J Douma, J Wals, A. Honkoop, F. Erdkamp, R. de Jong, C. Rodenburg, G Vreugdenhil, J. Akkermans-Vogelaar, et al.
Randomised study of sequential versus combination chemotherapy with capecitabine, irinotecan and oxaliplatin in advanced colorectal cancer, an interim safety analysis. A Dutch Colorectal Cancer Group (DCCG) phase III study
Ann. Onc.,
October 1, 2006;
17(10):
1523 - 1528.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. M. Goldberg
Therapy for Metastatic Colorectal Cancer
Oncologist,
October 1, 2006;
11(9):
981 - 987.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. Van Cutsem
Challenges in the Use of Epidermal Growth Factor Receptor Inhibitors in Colorectal Cancer
Oncologist,
October 1, 2006;
11(9):
1010 - 1017.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Giacchetti, G. Bjarnason, C. Garufi, D. Genet, S. Iacobelli, M. Tampellini, R. Smaaland, C. Focan, B. Coudert, Y. Humblet, et al.
Phase III Trial Comparing 4-Day Chronomodulated Therapy Versus 2-Day Conventional Delivery of Fluorouracil, Leucovorin, and Oxaliplatin As First-Line Chemotherapy of Metastatic Colorectal Cancer: The European Organisation for Research and Treatment of Cancer Chronotherapy Group
J. Clin. Oncol.,
August 1, 2006;
24(22):
3562 - 3569.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Glynne-Jones, S. Mawdsley, T. Pearce, and M. Buyse
Alternative clinical end points in rectal cancer--are we getting closer?
Ann. Onc.,
August 1, 2006;
17(8):
1239 - 1248.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Masi, L. Marcucci, F. Loupakis, E. Cerri, C. Barbara, S. Bursi, G. Allegrini, I. M. Brunetti, R. Murr, S. Ricci, et al.
First-line 5-fluorouracil/folinic acid, oxaliplatin and irinotecan (FOLFOXIRI) does not impair the feasibility and the activity of second line treatments in metastatic colorectal cancer
Ann. Onc.,
August 1, 2006;
17(8):
1249 - 1254.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. J. Meropol
Turning Point for Colorectal Cancer Clinical Trials
J. Clin. Oncol.,
July 20, 2006;
24(21):
3322 - 3324.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Poston, R. Adam, and J.-N. Vauthey
Downstaging or Downsizing: Time for a New Staging System in Advanced Colorectal Cancer?
J. Clin. Oncol.,
June 20, 2006;
24(18):
2702 - 2706.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. D. Wagner, W. Grothe, J. Haerting, G. Kleber, A. Grothey, and W. E. Fleig
Chemotherapy in Advanced Gastric Cancer: A Systematic Review and Meta-Analysis Based on Aggregate Data
J. Clin. Oncol.,
June 20, 2006;
24(18):
2903 - 2909.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Gill and D. Sargent
End points for adjuvant therapy trials: has the time come to accept disease-free survival as a surrogate end point for overall survival?
Oncologist,
June 1, 2006;
11(6):
624 - 629.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. E. Kemeny, D. Niedzwiecki, D. R. Hollis, H.-J. Lenz, R. S. Warren, M. J. Naughton, J. C. Weeks, E. R. Sigurdson, J. E. Herndon II, C. Zhang, et al.
Hepatic Arterial Infusion Versus Systemic Therapy for Hepatic Metastases From Colorectal Cancer: A Randomized Trial of Efficacy, Quality of Life, and Molecular Markers (CALGB 9481)
J. Clin. Oncol.,
March 20, 2006;
24(9):
1395 - 1403.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. A. P. Hospers, M. Schaapveld, J. W. R. Nortier, J. Wils, A. van Bochove, R. S. de Jong, G. J. Creemers, Z. Erjavec, D. J. de Gooyer, P. H. Th. J. Slee, et al.
Randomised Phase III study of biweekly 24-h infusion of high-dose 5FU with folinic acid and oxaliplatin versus monthly plus 5-FU/folinic acid in first-line treatment of advanced colorectal cancer
Ann. Onc.,
March 1, 2006;
17(3):
443 - 449.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. D. Pond, K. M. Marshall, and L. R. Barrows
Identification of a small topoisomerase I-binding peptide that has synergistic antitumor activity with 9-aminocamptothecin.
Mol. Cancer Ther.,
March 1, 2006;
5(3):
739 - 745.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B. Vincenzi, D. Santini, and G. Tonini
Lack of response of cetuximab plus oxaliplatin in advanced colorectal cancer patients resistant to both oxaliplatin and cetuximab plus irinotecan
Ann. Onc.,
March 1, 2006;
17(3):
527 - 528.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. Pfeiffer, H. Sorbye, H. Ehrsson, T. Fokstuen, J. P. Mortensen, L. Baltesgard, K. M. Tveit, D. Ogreid, H. Starkhammar, I. Wallin, et al.
Short-time infusion of oxaliplatin in combination with capecitabine (XELOX30) as second-line therapy in patients with advanced colorectal cancer after failure to irinotecan and 5-fluorouracil
Ann. Onc.,
February 1, 2006;
17(2):
252 - 258.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Grothey and D. Sargent
Overall Survival of Patients With Advanced Colorectal Cancer Correlates With Availability of Fluorouracil, Irinotecan, and Oxaliplatin Regardless of Whether Doublet or Single-Agent Therapy Is Used First Line
J. Clin. Oncol.,
December 20, 2005;
23(36):
9441 - 9442.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. J. Sargent, H. S. Wieand, D. G. Haller, R. Gray, J. K. Benedetti, M. Buyse, R. Labianca, J. F. Seitz, C. J. O'Callaghan, G. Francini, et al.
Disease-Free Survival Versus Overall Survival As a Primary End Point for Adjuvant Colon Cancer Studies: Individual Patient Data From 20,898 Patients on 18 Randomized Trials
J. Clin. Oncol.,
December 1, 2005;
23(34):
8664 - 8670.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. J. Poston, R. Adam, S. Alberts, S. Curley, J. Figueras, D. Haller, F. Kunstlinger, G. Mentha, B. Nordlinger, Y. Patt, et al.
OncoSurge: A Strategy for Improving Resectability With Curative Intent in Metastatic Colorectal Cancer
J. Clin. Oncol.,
October 1, 2005;
23(28):
7125 - 7134.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Gasparini, D. Gattuso, A. Morabito, R. Longo, F. Torino, R. Sarmiento, S. Vitale, T. Gamucci, and L. Mariani
Combined Therapy with Weekly Irinotecan, Infusional 5-Fluorouracil and the Selective COX-2 Inhibitor Rofecoxib Is a Safe and Effective Second-Line Treatment in Metastatic Colorectal Cancer
Oncologist,
October 1, 2005;
10(9):
710 - 717.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. de Gramont
Rapid Evolution in Colorectal Cancer: Therapy Now and Over the Next Five Years
Oncologist,
October 1, 2005;
10(suppl_2):
4 - 8.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. M. Goldberg
Advances in the Treatment of Metastatic Colorectal Cancer
Oncologist,
October 1, 2005;
10(suppl_3):
40 - 48.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. J. Cohen, R. B. Cohen, and N. J. Meropol
Targeting Signal Transduction Pathways in Colorectal Cancer--More Than Skin Deep
J. Clin. Oncol.,
August 10, 2005;
23(23):
5374 - 5385.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N Andre and W Schmiegel
CHEMORADIOTHERAPY FOR COLORECTAL CANCER
Gut,
August 1, 2005;
54(8):
1194 - 1202.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. D. Blanke
Whither Irinotecan?
J. Clin. Oncol.,
August 1, 2005;
23(22):
4811 - 4814.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Folprecht, A. Grothey, S. Alberts, H.-R. Raab, and C.-H. Kohne
Neoadjuvant treatment of unresectable colorectal liver metastases: correlation between tumour response and resection rates
Ann. Onc.,
August 1, 2005;
16(8):
1311 - 1319.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. Kelly and R. M. Goldberg
Systemic Therapy for Metastatic Colorectal Cancer: Current Options, Current Evidence
J. Clin. Oncol.,
July 10, 2005;
23(20):
4553 - 4560.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. F. Kabbinavar, J. Hambleton, R. D. Mass, H. I. Hurwitz, E. Bergsland, and S. Sarkar
Combined Analysis of Efficacy: The Addition of Bevacizumab to Fluorouracil/Leucovorin Improves Survival for Patients With Metastatic Colorectal Cancer
J. Clin. Oncol.,
June 1, 2005;
23(16):
3706 - 3712.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Venook
Critical Evaluation of Current Treatments in Metastatic Colorectal Cancer
Oncologist,
April 1, 2005;
10(4):
250 - 261.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. A. Meyerhardt and R. J. Mayer
Systemic Therapy for Colorectal Cancer
N. Engl. J. Med.,
February 3, 2005;
352(5):
476 - 487.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Masi, G. Allegrini, S. Cupini, L. Marcucci, E. Cerri, I. Brunetti, E. Fontana, S. Ricci, M. Andreuccetti, and A. Falcone
First-line treatment of metastatic colorectal cancer with irinotecan, oxaliplatin and 5-fluorouracil/leucovorin (FOLFOXIRI): results of a phase II study with a simplified biweekly schedule
Ann. Onc.,
December 1, 2004;
15(12):
1766 - 1772.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. H. J. Mathijssen, F. A. de Jong, R. H. N. van Schaik, E. R. Lepper, L. E. Friberg, T. Rietveld, P. de Bruijn, W. J. Graveland, W. D. Figg, J. Verweij, et al.
Prediction of Irinotecan Pharmacokinetics by Use of Cytochrome P450 3A4 Phenotyping Probes
J Natl Cancer Inst,
November 3, 2004;
96(21):
1585 - 1592.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. J. A. Punt
New options and old dilemmas in the treatment of patients with advanced colorectal cancer
Ann. Onc.,
October 1, 2004;
15(10):
1453 - 1459.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Chan and D. J. Kerr
Can we individualise chemotherapy for colorectal cancer?
Ann. Onc.,
July 1, 2004;
15(7):
996 - 999.
[Full Text]
[PDF]
|
 |
|
|