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New Developments in Lung Cancer Screening

James L. Mulshine

From the Cell and Cancer Biology Branch, National Institutes of Health, Bethesda, MD

Address reprint requests to James L. Mulshine, MD, Cell and Cancer Biology Branch, National Institutes of Health, Building 10, Room 12N226, Bethesda, MD 20892-1906; e-mail: mulshinej{at}bprb.nci.nih.gov.

Lung cancer is the most lethal cancer in our society. Late diagnosis of this disease is a major problem and so recent favorable reports with spiral computed tomography screening of high-risk populations have rekindled interest in improving early lung cancer detections. The process of lung cancer screening is a complicated process that involves many component activities. Interest to date has heavily focused on the initial case identification, but more recent reports have suggested that the issues with case work-up and surgical management also bear closer consideration. Given the dynamic nature of spiral computed tomography scan development and the remarkable improvements in imaging resolution over the last decade, there is an urgent need for research to establish optimal clinical management of early lung cancer detected in a screening setting.

The views expressed herein do not necessarily represent the views of the National Cancer Institute, National Institutes of Health, or Department of Health and Human Services.

Author's disclosures of potential conflicts of interest are found at the end of this article.

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