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Surgical Prevention of Cancer

Monica M. Bertagnolli

From the Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA

Address reprint requests to Monica M. Bertagnolli, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; e-mail: mbertagnolli{at}partners.org.

There have been many recent advances in cancer prevention, including improved understanding of cancer biology, better characterization of premalignant disease, significant advances in cancer surveillance, and identification of effective chemoprevention regimens. Despite this, surgery remains the best option for many individuals at high risk of cancer. Like all prevention modalities, surgical prevention involves balancing the factors governing cancer risk with the benefits and risks of treatment. The issues governing decision making for surgical prevention vary widely among different cancer types, and include consideration of the age and level of cancer risk of the individual, the effectiveness of cancer surveillance for the particular organ at risk, the aggressiveness of the cancer once present, and the morbidity of surgery. This article briefly reviews the use of surgery to prevent some of the most common epithelial malignancies, as well as some of the genetic cancer syndromes for which surgery plays an important role in improving survival.

Author's disclosures of potential conflicts of interest are found at the end of this article.

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