This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Save to my personal folders Download to citation manager Rights & Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schnell, R. Articles by Engert, A. Search for Related Content PubMed PubMed Citation Articles by Schnell, R. Articles by Engert, A. Social Bookmarking                            What's this?

Treatment of Refractory Hodgkin's Lymphoma Patients With an Iodine-131–Labeled Murine Anti-CD30 Monoclonal Antibody

From the Department of Internal Medicine I, Department of Nuclear Medicine, University of Cologne, Germany; Hopital Huriez, Lille, France; Department of Radioimmunotherapy, City of Hope National Medical Center, Duarte, CA

Address reprint requests to A. Engert; Klinik I fuer Innere Medizin, Universitaet zu Koeln, Joseph-Stelzmann-Strasse 9, D-50924 Koeln, Germany; e-mail: a.engert{at}uni-koeln.de

PURPOSE: Hodgkin's lymphoma (HL) has been demonstrated to be a good target for immunotherapy since lymphocyte activation markers such as CD30 are expressed in high numbers on the malignant cells. Thus, we developed a new radioimmunoconjugate consisting of the murine anti-CD30 monoclonal antibody (MAb) Ki-4 labeled with iodine-131 (¹³¹I).

PATIENTS AND METHODS: The biodistribution of ¹³¹I–Ki-4 was assessed via dosimetry after preinfusion of 5 mg native Ki-4 followed by 250 to 300 MBq ¹³¹I-labeled Ki-4. Whole-body scintigraphy was performed 1 hour, 24 hours, 48 hours, 72 hours, and 6 days after the infusion. Dosimetry was calculated using the programs NucliDose ICON-IDL (version 5.0.2; Siemens, Erlanger, Germany) and MIRDOSE (version 3.1; Oak Ridge National Laboratories; Oak Ridge, TN). The therapeutic dose was given on day 8 after preinfusion of unlabeled Ki-4.

RESULTS: We treated 22 patients with relapsed or refractory CD30-positive HL. Preinfusion of 5 mg native Ki-4 was sufficient to bind the soluble CD30. Imaging demonstrated localization of involved areas measuring 5 cm in diameter or more in four patients and 2.5 cm in one patient. Patients received total body doses of 0.035 Gy to 0.99 Gy. Acute toxicity was mild with grade 1 fatigue in 19 of 22 assessable patients. Seven patients experienced grade 4 degrees hematotoxicity 4 to 8 weeks after treatment. Response included one complete remission, five partial remissions, and three minor responses.

CONCLUSION: Treatment with ¹³¹I–Ki-4 is effective but can be associated with severe hematotoxicity.

Supported in part by Deutsche Krebshilfe, grant 10-1899-En3, and Koeln Fortune program, Faculty of Medicine, University of Cologne, grant 149/2001.

Presented, in part, as oral presentation at the 42nd Annual Meeting of the American Society of Hematology, Philadelphia, PA, December 6-10, 2002, and the 16th Annual Congress of the European Association of Nuclear Medicine, Amsterdam, the Netherlands, August 23-27, 2003.

R.S. and M.D. contributed equally to this work.

Authors' disclosures of potential conflicts of interest are found at the end of this article.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				G. Dancey, J. Violet, A. Malaroda, A. J. Green, S. K. Sharma, R. Francis, S. Othman, S. Parker, J. Buscombe, N. Griffin, et al. A Phase I Clinical Trial of CHT-25 a 131I-Labeled Chimeric Anti-CD25 Antibody Showing Efficacy in Patients with Refractory Lymphoma Clin. Cancer Res., December 15, 2009; 15(24): 7701 - 7710. [Abstract] [Full Text] [PDF]

				P. M. Cardarelli, M.-C. Moldovan-Loomis, B. Preston, A. Black, D. Passmore, T.-H. Chen, S. Chen, J. Liu, M. R. Kuhne, M. Srinivasan, et al. In vitro and In vivo Characterization of MDX-1401 for Therapy of Malignant Lymphoma Clin. Cancer Res., May 15, 2009; 15(10): 3376 - 3383. [Abstract] [Full Text] [PDF]

				A. Younes Novel treatment strategies for patients with relapsed classical Hodgkin lymphoma Hematology, January 1, 2009; 2009(1): 507 - 519. [Abstract] [Full Text] [PDF]

				B. Savoldo, C. M. Rooney, A. Di Stasi, H. Abken, A. Hombach, A. E. Foster, L. Zhang, H. E. Heslop, M. K. Brenner, and G. Dotti Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30{zeta} artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease Blood, October 1, 2007; 110(7): 2620 - 2630. [Abstract] [Full Text] [PDF]

				N. Keshelava, E. Davicioni, Z. Wan, L. Ji, R. Sposto, T. J. Triche, and C. P. Reynolds Histone Deacetylase 1 Gene Expression and Sensitization of Multidrug-Resistant Neuroblastoma Cell Lines to Cytotoxic Agents by Depsipeptide J Natl Cancer Inst, July 18, 2007; 99(14): 1107 - 1119. [Abstract] [Full Text] [PDF]

				S. M. Ansell, S. M. Horwitz, A. Engert, K. D. Khan, T. Lin, R. Strair, T. Keler, R. Graziano, D. Blanset, M. Yellin, et al. Phase I/II Study of an Anti-CD30 Monoclonal Antibody (MDX-060) in Hodgkin's Lymphoma and Anaplastic Large-Cell Lymphoma J. Clin. Oncol., July 1, 2007; 25(19): 2764 - 2769. [Abstract] [Full Text] [PDF]

				B. J. Byrne and J. P. Gockerman Salvage Therapy in Hodgkin's Lymphoma Oncologist, February 1, 2007; 12(2): 156 - 167. [Abstract] [Full Text] [PDF]

				D. A. Eichenauer, V. L. Simhadri, E. P. von Strandmann, A. Ludwig, V. Matthews, K. S. Reiners, B. von Tresckow, P. Saftig, S. Rose-John, A. Engert, et al. ADAM10 Inhibition of Human CD30 Shedding Increases Specificity of Targeted Immunotherapy In vitro Cancer Res., January 1, 2007; 67(1): 332 - 338. [Abstract] [Full Text] [PDF]

				E. Jacobsen Anaplastic Large-Cell Lymphoma, T-/Null-Cell Type Oncologist, July 1, 2006; 11(7): 831 - 840. [Abstract] [Full Text] [PDF]

				P. Carde The Chemotherapy/Radiation Balance in Advanced Hodgkin's Lymphoma: Overweight Which Side? J. Clin. Oncol., December 20, 2005; 23(36): 9058 - 9062. [Full Text] [PDF]