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Novel Immune-Based Treatment Strategies for Chronic Lymphocytic Leukemia

William G. Wierda, Thomas J. Kipps, Michael J. Keating

From the Department of Leukemia, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Department of Medicine, Division of Hematology and Oncology, University of California, San Diego, San Diego, CA; and the Chronic Lymphocytic Leukemia Research Consortium, San Diego, CA

Address reprint requests to William G. Wierda, MD, PhD, The University of Texas M.D. Anderson Cancer Center, Department of Leukemia, 1515 Holcombe Blvd, Unit 428, Houston, TX 77030; e-mail: wwierda{at}mdanderson.org.

Immune-based treatments represent a new group of therapeutic strategies for patients with cancer, including chronic lymphocytic leukemia (CLL), that employ immune effector mechanisms. Among these strategies is passive immunotherapy with monoclonal antibody, alone or in combination with chemotherapy. Active immunotherapy strategies currently under development include vaccines, administration of expanded and activated T cells, and allogeneic stem cell transplantation. These immune-based strategies represent new treatments with potentially complementary mechanisms of action to standard therapies and signify major advances in treatments for patients with CLL.

Authors' disclosures of potential conflicts of interest are found at the end of this article.

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