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Molecular Pathogenesis of Diffuse Large B-Cell Lymphoma

Izidore S. Lossos

From the Sylvester Comprehensive Cancer Center, Division of Hematology-Oncology, Department of Medicine, Department of Molecular and Cellular Pharmacology, University of Miami, Miami, FL

Address reprint requests to Izidore S. Lossos, MD, University of Miami, Sylvester Comprehensive Cancer Center, Department of Hematology and Oncology, 1475 NW 12th Ave (D8-4), Miami, FL 33136; e-mail: ilossos{at}med.miami.edu.

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous clinicopathologic entity accounting for 30% of non-Hodgkin's lymphomas. The pathogenesis of DLBCL is complex and heterogeneous. Recent studies using analysis of global gene expression with DNA microarrays and the classical molecular approaches demonstrate presence of several DLBCL subtypes characterized by different cells of origin, cytogenetic and molecular aberrations, and distinct pathogenesis. This review summarizes the progress in understanding of DLBCL biology and presents a state-of-the-art overview of DLBCL molecular pathogenesis.

Supported by Grant No. RO1 CA109335 from the United States Public Health Service National Institutes of Health and the Dwoskin Family Foundation.

Author's disclosures of potential conflicts of interest are found at the end of this article.

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