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Originally published as JCO Early Release 10.1200/JCO.2005.07.040 on December 21 2004

Journal of Clinical Oncology, Vol 23, No 4 (February 1), 2005: pp. 712-719
© 2005 American Society of Clinical Oncology.
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Efficacy and Safety of Tositumomab and Iodine-131 Tositumomab (Bexxar) in B-Cell Lymphoma, Progressive After Rituximab

Sandra J. Horning, Anas Younes, Vinay Jain, Stewart Kroll, Jennifer Lucas, Donald Podoloff, Michael Goris

From Stanford University, Stanford, CA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; US Oncology, Dallas, TX; Corixa Corp, South San Francisco, CA

Address reprint requests to Sandra J. Horning, MD, Stanford University, 875 Blake Wilbur Dr, Suite CC-2338, Stanford, CA 94305-5821; e-mail: sandra.horning{at}stanford.edu

PURPOSE: To determine overall response (OR) and complete response (CR) rates, response duration, progression-free (PFS) and overall survival and safety with the tositumomab and iodine-131 tositumomab (131I tositumomab) therapeutic regimen in patients with indolent, follicular large-cell, or transformed B-cell lymphoma, progressive after rituximab.

PATIENTS AND METHODS: From July 1998 to November 1999, 40 patients (24 rituximab nonresponders: 11 with response < 6 months, and five with response ≥ 6 months) received a therapeutic dose (0.65 to 0.75 Gy per platelet count) of 131I tositumomab based on total-body dosimetry in this prospective phase II study. The median number of prior treatments was four; 59% of patients were chemotherapy-resistant.

RESULTS: Confirmed OR (65%) and CR (38%) rates were not significantly associated with prior rituximab response. With a median follow-up of 3.3 years, the median PFS was 10.4 months, 24.5 months for responders, and not reached for CR patients. Among follicular grade 1 or 2 patients with tumors ≤ 7 cm (n = 21), the OR and CR rates were 86% and 57%. Estimated 3-year PFS in this subgroup was 48%, compared with 11% for all others (P = .002). Transient grade 3 to 4 marrow toxicity was seen in 50% of patients. Two patients, one of whom received two subsequent chemotherapy regimens, developed secondary myelodysplasia.

CONCLUSION: 131I tositumomab is effective in CD20-positive lymphoma progressive after rituximab, with a 65% OR rate and median PFS of 24.5 months for responders. Patients with follicular grade 1 or 2 histology and tumors ≤ 7 cm achieved very high OR and CR rates, with 48% PFS at 3 years.

Supported by a grant from Corixa Corporation, South San Francisco, CA.

Presented in part at the Annual Meeting of the American Society of Hematology, San Francisco, CA, December 5-8, 2000.

Authors' disclosures of potential conflicts of interest are found at the end of this article.


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