Advertisement
Journal of Clinical Oncology  
Search for:
Limit by:
  Browse by Subject or Issue
Home Search or Browse JCO My JCO Subscriptions Customer Service Site Map

Journal of Clinical Oncology, Vol 23, No 7 (March 1), 2005: pp. 1420-1430
© 2005 American Society of Clinical Oncology.
DOI: 10.1200/JCO.2005.08.140
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Erratum (v23,p4808)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Save to my personal folders
Right arrow Download to citation manager
Right arrowRights & Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cristofanilli, M.
Right arrow Articles by Terstappen, L. W.M.M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cristofanilli, M.
Right arrow Articles by Terstappen, L. W.M.M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Circulating Tumor Cells: A Novel Prognostic Factor for Newly Diagnosed Metastatic Breast Cancer

Massimo Cristofanilli, Daniel F. Hayes, G. Thomas Budd, Mathew J. Ellis, Alison Stopeck, James M. Reuben, Gerald V. Doyle, Jeri Matera, W. Jeffrey Allard, M. Craig Miller, Herbert A. Fritsche, Gabriel N. Hortobagyi, Leon W.M.M. Terstappen

From The University of Texas M.D. Anderson Cancer Center, Houston, TX; The University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; The Cleveland Clinic, Cleveland, OH; Washington University, St Louis, MO; University of Arizona, Phoenix, AZ; and Immunicon Corporation, Huntingdon Valley, PA

Address reprint requests to Massimo Cristofanilli, MD, FACP, Department of Breast Medical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 424, Houston, TX 77030; e-mail: mcristof{at}mdanderson.org

PURPOSE: Metastatic breast cancer (MBC) is incurable; its treatment is palliative. We investigated whether the presence of circulating tumor cells (CTCs) predicts treatment efficacy, progression-free survival (PFS), and overall survival (OS) in patients with newly diagnosed MBC who were about to start first-line therapy.

PATIENTS AND METHODS: One hundred seventy-seven patients with measurable MBC were enrolled onto a prospective study. Eighty-three of the 177 patients were entering first-line treatment, and these patients are the focus of this analysis. CTCs from 7.5 mL of whole blood drawn before treatment initiation (baseline) and monthly thereafter for up to 6 months were isolated and enumerated using immunomagnetics.

RESULTS: The mean (± standard deviation) follow-up time was 11.1 ± 4.4 months (median, 12.2 months). Forty-three patients (52%) had ≥ five CTCs at baseline. The median PFS was 7.2 months (95% CI, 4.9 to 9.4 months), and the median OS was more than 18 months. Patients with ≥ five CTCs at baseline and at first follow-up (4 weeks) had a worse prognosis than patients with less than five CTCs (baseline: median PFS, 4.9 v 9.5 months, respectively; log-rank, P = .0014; median OS, 14.2 v > 18 months, respectively; log-rank, P = .0048; first follow-up: median PFS, 2.1 v 8.9 months, respectively; log-rank, P = .0070; median OS, 11.1 v > 18 months, respectively; log-rank, P = .0029). CTCs before and after the initiation of therapy were strong, independent prognostic factors.

CONCLUSION: Detection of CTCs before initiation of first-line therapy in patients with MBC is highly predictive of PFS and OS. This technology can aid in appropriate patient stratification and design of tailored treatments.

Supported by Immunicon Corporation, Huntingdon Valley, PA.

Authors’ disclosures of potential conflicts of interest are found at the end of this article.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JCOHome page
U. De Giorgi, V. Valero, E. Rohren, S. Dawood, N. T. Ueno, M. C. Miller, G. V. Doyle, S. Jackson, E. Andreopoulou, B. C. Handy, et al.
Circulating Tumor Cells and [18F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Outcome Prediction in Metastatic Breast Cancer
J. Clin. Oncol., July 10, 2009; 27(20): 3303 - 3311.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
O. B. Goodman Jr., L. M. Fink, J. T. Symanowski, B. Wong, B. Grobaski, D. Pomerantz, Y. Ma, D. C. Ward, and N. J. Vogelzang
Circulating Tumor Cells in Patients with Castration-Resistant Prostate Cancer Baseline Values and Correlation with Prognostic Factors
Cancer Epidemiol. Biomarkers Prev., June 1, 2009; 18(6): 1904 - 1913.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
Y. Okumura, F. Tanaka, K. Yoneda, M. Hashimoto, T. Takuwa, N. Kondo, and S. Hasegawa
Circulating Tumor Cells in Pulmonary Venous Blood of Primary Lung Cancer Patients.
Ann. Thorac. Surg., June 1, 2009; 87(6): 1669 - 1675.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
P. Helo, A. M. Cronin, D. C. Danila, S. Wenske, R. Gonzalez-Espinoza, A. Anand, M. Koscuiszka, R.-M. Vaananen, K. Pettersson, F. K.-H. Chun, et al.
Circulating Prostate Tumor Cells Detected by Reverse Transcription-PCR in Men with Localized or Castration-Refractory Prostate Cancer: Concordance with CellSearch Assay and Association with Bone Metastases and with Survival
Clin. Chem., April 1, 2009; 55(4): 765 - 773.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R. Le Scodan, D. Stevens, E. Brain, J. L. Floiras, C. Cohen-Solal, B. De La Lande, M. Tubiana-Hulin, S. Yacoub, M. Gutierrez, D. Ali, et al.
Breast Cancer With Synchronous Metastases: Survival Impact of Exclusive Locoregional Radiotherapy
J. Clin. Oncol., March 20, 2009; 27(9): 1375 - 1381.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. C. C. Wong, C. M. L. Chan, B. B. Y. Ma, E. P. Hui, S. S. M. Ng, P. B. S. Lai, M. T. Cheung, E. S. F. Lo, A. K. C. Chan, M. Y. Y. Lam, et al.
Clinical Significance of Cytokeratin 20-Positive Circulating Tumor Cells Detected by a Refined Immunomagnetic Enrichment Assay in Colorectal Cancer Patients
Clin. Cancer Res., February 1, 2009; 15(3): 1005 - 1012.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. M. Sieuwerts, J. Kraan, J. Bolt, P. van der Spoel, F. Elstrodt, M. Schutte, J. W. M. Martens, J.-W. Gratama, S. Sleijfer, and J. A. Foekens
Anti-Epithelial Cell Adhesion Molecule Antibodies and the Detection of Circulating Normal-Like Breast Tumor Cells
J Natl Cancer Inst, January 7, 2009; 101(1): 61 - 66.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
D. Olmos, H.-T. Arkenau, J. E. Ang, I. Ledaki, G. Attard, C. P. Carden, A. H. M. Reid, R. A'Hern, P. C. Fong, N. B. Oomen, et al.
Circulating tumour cell (CTC) counts as intermediate end points in castration-resistant prostate cancer (CRPC): a single-centre experience
Ann. Onc., January 1, 2009; 20(1): 27 - 33.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
K. Hiraiwa, H. Takeuchi, H. Hasegawa, Y. Saikawa, K. Suda, T. Ando, K. Kumagai, T. Irino, T. Yoshikawa, S. Matsuda, et al.
Clinical Significance of Circulating Tumor Cells in Blood from Patients with Gastrointestinal Cancers
Ann. Surg. Oncol., November 1, 2008; 15(11): 3092 - 3100.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J.-Y. Pierga, F.-C. Bidard, C. Mathiot, E. Brain, S. Delaloge, S. Giachetti, P. de Cremoux, R. Salmon, A. Vincent-Salomon, and M. Marty
Circulating Tumor Cell Detection Predicts Early Metastatic Relapse After Neoadjuvant Chemotherapy in Large Operable and Locally Advanced Breast Cancer in a Phase II Randomized Trial
Clin. Cancer Res., November 1, 2008; 14(21): 7004 - 7010.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. S. de Bono, H. I. Scher, R. B. Montgomery, C. Parker, M. C. Miller, H. Tissing, G. V. Doyle, L. W.W.M. Terstappen, K. J. Pienta, and D. Raghavan
Circulating Tumor Cells Predict Survival Benefit from Treatment in Metastatic Castration-Resistant Prostate Cancer
Clin. Cancer Res., October 1, 2008; 14(19): 6302 - 6309.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. Alix-Panabieres, S. Riethdorf, and K. Pantel
Circulating Tumor Cells and Bone Marrow Micrometastasis
Clin. Cancer Res., August 15, 2008; 14(16): 5013 - 5021.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J. H. Schiller
Noninvasive Monitoring of Tumors
N. Engl. J. Med., July 24, 2008; 359(4): 418 - 420.
[Full Text] [PDF]

Home page
 NEJMHome page
S. Maheswaran, L. V. Sequist, S. Nagrath, L. Ulkus, B. Brannigan, C. V. Collura, E. Inserra, S. Diederichs, A. J. Iafrate, D. W. Bell, et al.
Detection of Mutations in EGFR in Circulating Lung-Cancer Cells
N. Engl. J. Med., July 24, 2008; 359(4): 366 - 377.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J.-P. Eliane, M. Repollet, K. E. Luker, M. Brown, J. M. Rae, G. Dontu, A. F. Schott, M. Wicha, G. V. Doyle, D. F. Hayes, et al.
Monitoring Serial Changes in Circulating Human Breast Cancer Cells in Murine Xenograft Models
Cancer Res., July 15, 2008; 68(14): 5529 - 5532.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
M. Campos, C. Prior, F. Warleta, I. Zudaire, J. Ruiz-Mora, R. Catena, A. Calvo, and J. J. Gaforio
Phenotypic and Genetic Characterization of Circulating Tumor Cells by Combining Immunomagnetic Selection and FICTION Techniques
J. Histochem. Cytochem., July 1, 2008; 56(7): 667 - 675.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. F. Hayes and J. Smerage
Is There a Role for Circulating Tumor Cells in the Management of Breast Cancer?
Clin. Cancer Res., June 15, 2008; 14(12): 3646 - 3650.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
F. Nole, E. Munzone, L. Zorzino, I. Minchella, M. Salvatici, E. Botteri, M. Medici, E. Verri, L. Adamoli, N. Rotmensz, et al.
Variation of circulating tumor cell levels during treatment of metastatic breast cancer: prognostic and therapeutic implications
Ann. Onc., May 1, 2008; 19(5): 891 - 897.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
J. Sastre, M. L. Maestro, J. Puente, S. Veganzones, R. Alfonso, S. Rafael, J. A. Garcia-Saenz, M. Vidaurreta, M. Martin, M. Arroyo, et al.
Circulating tumor cells in colorectal cancer: correlation with clinical and pathological variables
Ann. Onc., May 1, 2008; 19(5): 935 - 938.
[Abstract] [Full Text] [PDF]

Home page
 aacredbookHome page
M C. Miller, G. V Doyle, and L. W M M Terstappen
Monitoring and Characterization of CTC in Cancer Patients
Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 617 - 624.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
L. Pusztai
Current Status of Prognostic Profiling in Breast Cancer
Oncologist, April 1, 2008; 13(4): 350 - 360.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
H. D. Bear
Measuring Circulating Tumor Cells As a Surrogate End Point for Adjuvant Therapy of Breast Cancer: What Do They Mean and What Should We Do About Them?
J. Clin. Oncol., March 10, 2008; 26(8): 1195 - 1197.
[Full Text] [PDF]

Home page
 Ann OncolHome page
F.-C. Bidard, A. Vincent-Salomon, B. Sigal-Zafrani, V. Dieras, C. Mathiot, L. Mignot, J.-P. Thiery, X. Sastre-Garau, and J.-Y. Pierga
Prognosis of women with stage IV breast cancer depends on detection of circulating tumor cells rather than disseminated tumor cells
Ann. Onc., March 1, 2008; 19(3): 496 - 500.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
A. Stojadinovic, E. A. Mittendorf, J. P. Holmes, A. Amin, M. T. Hueman, S. Ponniah, and G. E. Peoples
Quantification and Phenotypic Characterization of Circulating Tumor Cells for Monitoring Response to a Preventive HER2/neu Vaccine-Based Immunotherapy for Breast Cancer: A Pilot Study
Ann. Surg. Oncol., December 1, 2007; 14(12): 3359 - 3368.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. C. Danila, G. Heller, G. A. Gignac, R. Gonzalez-Espinoza, A. Anand, E. Tanaka, H. Lilja, L. Schwartz, S. Larson, M. Fleisher, et al.
Circulating Tumor Cell Number and Prognosis in Progressive Castration-Resistant Prostate Cancer
Clin. Cancer Res., December 1, 2007; 13(23): 7053 - 7058.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
L. Harris, H. Fritsche, R. Mennel, L. Norton, P. Ravdin, S. Taube, M. R. Somerfield, D. F. Hayes, and R. C. Bast Jr
American Society of Clinical Oncology 2007 Update of Recommendations for the Use of Tumor Markers in Breast Cancer
J. Clin. Oncol., November 20, 2007; 25(33): 5287 - 5312.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Nakagawa, S. R. Martinez, Y. Goto, K. Koyanagi, M. Kitago, T. Shingai, D. A. Elashoff, X. Ye, F. R. Singer, A. E. Giuliano, et al.
Detection of Circulating Tumor Cells in Early-Stage Breast Cancer Metastasis to Axillary Lymph Nodes
Clin. Cancer Res., July 15, 2007; 13(14): 4105 - 4110.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. He, H. Wang, L. C. Hartmann, J.-X. Cheng, and P. S. Low
In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry
PNAS, July 10, 2007; 104(28): 11760 - 11765.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
L. Xi, D. G. Nicastri, T. El-Hefnawy, S. J. Hughes, J. D. Luketich, and T. E. Godfrey
Optimal Markers for Real-Time Quantitative Reverse Transcription PCR Detection of Circulating Tumor Cells from Melanoma, Breast, Colon, Esophageal, Head and Neck, and Lung Cancers
Clin. Chem., July 1, 2007; 53(7): 1206 - 1215.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Z. Liu, M. Jiang, J. Zhao, and H. Ju
Circulating Tumor Cells in Perioperative Esophageal Cancer Patients: Quantitative Assay System and Potential Clinical Utility
Clin. Cancer Res., May 15, 2007; 13(10): 2992 - 2997.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
S Apostolaki, M Perraki, A Pallis, V Bozionelou, S Agelaki, P Kanellou, A Kotsakis, E Politaki, K Kalbakis, A Kalykaki, et al.
Circulating HER2 mRNA-positive cells in the peripheral blood of patients with stage I and II breast cancer after the administration of adjuvant chemotherapy: evaluation of their clinical relevance
Ann. Onc., May 1, 2007; 18(5): 851 - 858.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. R. Shaffer, M. A. Leversha, D. C. Danila, O. Lin, R. Gonzalez-Espinoza, B. Gu, A. Anand, K. Smith, P. Maslak, G. V. Doyle, et al.
Circulating Tumor Cell Analysis in Patients with Progressive Castration-Resistant Prostate Cancer
Clin. Cancer Res., April 1, 2007; 13(7): 2023 - 2029.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Riethdorf, H. Fritsche, V. Muller, T. Rau, C. Schindlbeck, B. Rack, W. Janni, C. Coith, K. Beck, F. Janicke, et al.
Detection of Circulating Tumor Cells in Peripheral Blood of Patients with Metastatic Breast Cancer: A Validation Study of the CellSearch System
Clin. Cancer Res., February 1, 2007; 13(3): 920 - 928.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
M. Lacroix
Significance, detection and markers of disseminated breast cancer cells
Endocr. Relat. Cancer, December 1, 2006; 13(4): 1033 - 1067.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Cristofanilli and J. Mendelsohn
Circulating tumor cells in breast cancer: Advanced tools for "tailored" therapy?
PNAS, November 14, 2006; 103(46): 17073 - 17074.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. W. Sledge Jr.
Circulating tumor cells in breast cancer: blood will tell.
Clin. Cancer Res., November 1, 2006; 12(21): 6321 - 6322.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. T. Budd, M. Cristofanilli, M. J. Ellis, A. Stopeck, E. Borden, M. C. Miller, J. Matera, M. Repollet, G. V. Doyle, L. W.M.M. Terstappen, et al.
Circulating Tumor Cells versus Imaging--Predicting Overall Survival in Metastatic Breast Cancer.
Clin. Cancer Res., November 1, 2006; 12(21): 6403 - 6409.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. F. Hayes, M. Cristofanilli, G. T. Budd, M. J. Ellis, A. Stopeck, M. C. Miller, J. Matera, W. J. Allard, G. V. Doyle, and L. W.W.M. Terstappen
Circulating Tumor Cells at Each Follow-up Time Point during Therapy of Metastatic Breast Cancer Patients Predict Progression-Free and Overall Survival.
Clin. Cancer Res., July 15, 2006; 12(14): 4218 - 4224.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
E. Rapiti, H. M. Verkooijen, G. Vlastos, G. Fioretta, I. Neyroud-Caspar, A. P. Sappino, P. O. Chappuis, and C. Bouchardy
Complete Excision of Primary Breast Tumor Improves Survival of Patients With Metastatic Breast Cancer at Diagnosis
J. Clin. Oncol., June 20, 2006; 24(18): 2743 - 2749.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
V. H.C. Bramwell, G. S. Doig, A. B. Tuck, S. M. Wilson, K. S. Tonkin, A. Tomiak, F. Perera, T. A. Vandenberg, and A. F. Chambers
Serial plasma osteopontin levels have prognostic value in metastatic breast cancer.
Clin. Cancer Res., June 1, 2006; 12(11): 3337 - 3343.
[Abstract] [Full Text] [PDF]

Home page
 CA Cancer J ClinHome page
S. E. Singletary and J. L. Connolly
Breast Cancer Staging: Working With the Sixth Edition of the AJCC Cancer Staging Manual
CA Cancer J Clin, January 1, 2006; 56(1): 37 - 47.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
P. L. Blanco, J. C. A. Marshall, E. Antecka, S. A. Callejo, J. P. Souza Filho, V. Saraiva, and M. N. Burnier Jr
Characterization of Ocular and Metastatic Uveal Melanoma in an Animal Model
Invest. Ophthalmol. Vis. Sci., December 1, 2005; 46(12): 4376 - 4382.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
N. Dandachi, M. Balic, S. Stanzer, M. Halm, M. Resel, T. A. Hinterleitner, H. Samonigg, and T. Bauernhofer
Critical Evaluation of Real-Time Reverse Transcriptase-Polymerase Chain Reaction for the Quantitative Detection of Cytokeratin 20 mRNA in Colorectal Cancer Patients
J. Mol. Diagn., November 1, 2005; 7(5): 631 - 637.
[Abstract] [Full Text] [PDF]


About
JCO		 Editorial
Roster		 Advertising
Information		 Librarians &
Institutions		 Rights &
Permissions		 PDA Services

Copyright © 2005 by the American Society of Clinical Oncology, Online ISSN: 1527-7755. Print ISSN: 0732-183X
Terms and Conditions of Use
  HighWire Press HighWire Press™ assists in the publication of JCO Online