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Dynamic Contrast-Enhanced Magnetic Resonance Imaging As an Imaging Biomarker

From the University of California, San Francisco, San Francisco, CA

Address reprint requests to Nola Hylton, PhD, Box 1290, University of California, San Francisco, San Francisco, CA 94143-1290; e-mail: nola.hylton{at}radiology.ucsf.edu

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is being used in oncology as a noninvasive method for measuring properties of the tumor microvasculature. There is potential for DCE-MRI to be used as an imaging biomarker to measure antiangiogenic effects of cancer treatments. This article reviews the general methodology for performing DCE-MRI and discusses existing data and challenges to applying DCE-MRI for treatment response assessment in clinical trials.

Author's disclosures of potential conflicts of interest are found at the end of this article.

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