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Systematic Review on the Efficacy of Cytoreductive Surgery Combined With Perioperative Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis From Colorectal Carcinoma

Tristan D. Yan, Deborah Black, Renaldo Savady, Paul H. Sugarbaker

From the Peritoneal Surface Malignancy Program, Washington Cancer Institute, Washington, DC; and the School of Public Health and Community Medicine, The University of New South Wales, Sydney, Australia

Address reprint requests to Paul H. Sugarbaker, MD, 106 Irving St, NW, Suite 3900N, Washington, DC, 20010; e-mail: Paul.Sugarbaker{at}medstar.net

PURPOSE: The efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for patients with peritoneal carcinomatosis from colorectal carcinoma remains to be established.

METHODS: A systematic review of relevant studies before March 2006 was performed. Two reviewers independently appraised each study using a predetermined protocol. The quality of studies was assessed. Clinical effectiveness was synthesized through a narrative review with full tabulation of results of all included studies.

RESULTS: Two randomized controlled trials, one comparative study, one multi-institutional registry study, and 10 most recent case-series studies were evaluated. The level of evidence was low in 13 of the 14 eligible studies. The median survival varied from 13 to 29 months, and 5-year survival rates ranged from 11% to 19%. Patients who received complete cytoreduction benefited most, with median survival varying from 28 to 60 months and 5-year survival ranging from 22% to 49%. The overall morbidity rate varied from 23% to 44%, and the mortality rate ranged from 0% to 12%.

CONCLUSION: The current evidence suggests that cytoreductive surgery combined with perioperative intraperitoneal chemotherapy is associated with an improved survival, as compared with systemic chemotherapy for peritoneal carcinomatosis from colorectal carcinoma.

Supported by sponsorship from Foundation for Applied Research in Gastrointestinal Oncology and MedStar Research Institute (T.D.Y.).

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.

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