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Disadvantage of Men Living Alone Participating in Radiation Therapy Oncology Group Head and Neck Trials

Andre A. Konski, Thomas F. Pajak, Benjamin Movsas, James Coyne, Jonathan Harris, Clement Gwede, Adam Garden, Sharon Spencer, Christopher Jones, Deborah Watkins-Bruner

From the Departments of Radiation Oncology and Population Sciences, Fox Chase Cancer Center; Statistical Headquarters, Radiation Therapy Oncology Group; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center, Tampa, FL; Department of Radiation Oncology, M.D. Anderson Cancer Center, Houston TX; Department of Radiation Oncology, University of Alabama-Birmingham, Birmingham, AL; and Radiological Associates of Sacramento, Sacramento, CA

Address reprint requests to Andre A. Konski, MD, MBA, MA, Department of Radiation Oncology, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111; e-mail: andre.konski{at}fccc.edu

Purpose: This study evaluated whether males without partners were disadvantaged for survival in Radiation Therapy Oncology Group (RTOG) head and neck cancer clinical trials.

Methods: Patients treated on three RTOG trials were studied. The Cox proportional hazards model was used to determine if sex and the interaction between sex and marital/partner status were independent prognostic variables for overall survival controlling for Karnofsky performance status, tumor stage, nodal stage, primary site, and protocol treatment.

Results: A total of 1,901 patients (1,509 men) were entered onto the three RTOG trials, with 1,822 (1,438 men) analyzable patients. Prognostic variables independent of disease-related variables for survival in multivariate analyses restricted to men were age, marital/partner status, and income.

Conclusion: The apparent disadvantage of unpartnered men is striking, even after controlling for disease and other demographic variables. Possible explanations could easily be tested in observational studies, leading to evaluation of simple interventions to improve their outcome.

Supported by the Pennsylvania Commonwealth Universal Research Enhancement (CURE) Program Grant No. ME-02-149.

Presented at the 40th Annual Meeting of the American Society of Clinical Oncology, New Orleans, LA, June 5-8, 2004.

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.