Advertisement
Journal of Clinical Oncology  
Search for:
Limit by:
  Browse by Subject or Issue
Home Search or Browse JCO My JCO Subscriptions Customer Service Site Map

Journal of Clinical Oncology, Vol 24, No 31 (November 1), 2006: pp. 5034-5042
© 2006 American Society of Clinical Oncology.
DOI: 10.1200/JCO.2006.06.3958
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Save to my personal folders
Right arrow Download to citation manager
Right arrowRights & Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hirsch, F. R.
Right arrow Articles by Holloway, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hirsch, F. R.
Right arrow Articles by Holloway, B.
Related Articles
Right arrowRelated Correspondence
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Molecular Predictors of Outcome With Gefitinib in a Phase III Placebo-Controlled Study in Advanced Non–Small-Cell Lung Cancer

Fred R. Hirsch, Marileila Varella-Garcia, Paul A. Bunn, Jr, Wilbur A. Franklin, Rafal Dziadziuszko, Nick Thatcher, Alex Chang, Purvish Parikh, José Rodrigues Pereira, Tudor Ciuleanu, Joachim von Pawel, Claire Watkins, Angela Flannery, Gillian Ellison, Emma Donald, Lucy Knight, Dinah Parums, Nicholas Botwood, Brian Holloway

From the University of Colorado Cancer Center, Aurora, CO; Medical University of Gdansk, Gdansk, Poland; Christie Hospital, Manchester; AstraZeneca, Macclesfield, United Kingdom; Johns Hopkins Singapore International Medical Center, Singapore; Tata Memorial Hospital, Mumbai, India; Arnaldo Vieira de Carvalho Cancer Institute, São Paulo, Brazil; Oncology Institute Ion Chiricuta, Cluj-Napoca, Romania; and Asklepios Fachkliniken, Gauting, Germany

Address reprint requests to Fred R. Hirsch, MD, PhD, University of Colorado Cancer Center, PO Box 6511, Mail Stop 8111, Aurora, CO 80045; e-mail: Fred.Hirsch{at}UCHSC.edu

Purpose The phase III Iressa Survival Evaluation in Lung Cancer (ISEL) trial compared gefitinib with placebo in 1,692 patients with refractory advanced non–small-cell lung cancer. We analyzed ISEL tumor biopsy samples to examine relationships between biomarkers and clinical outcome after gefitinib treatment in a placebo-controlled setting.

Methods Biomarkers included epidermal growth factor receptor (EGFR) gene copy number by fluorescence in situ hybridization (n = 370); EGFR (n = 379) and phosphorylated Akt (p-Akt) protein expression (n = 382) by immunohistochemistry; and mutations in EGFR (n = 215), KRAS (n = 152), and BRAF (n = 118).

Results High EGFR gene copy number was a predictor of a gefitinib-related effect on survival (hazard ratio [HR], 0.61 for high copy number and HR, 1.16 for low copy number; comparison of high v low copy number HR, P = .045). EGFR protein expression was also related to clinical outcome (HR for positive, 0.77; HR for negative, 1.57; comparison of high v low protein expression HR, P = .049). Patients with EGFR mutations had higher response rates than patients without EGFR mutations (37.5% v 2.6%); there were insufficient data for survival analysis. No relationship was observed between p-Akt protein expression and survival outcome, and the limited amount of data collected for KRAS and BRAF mutations prevented any meaningful evaluation of clinical outcomes in relation to these mutations.

Conclusion EGFR gene copy number was a predictor of clinical benefit from gefitinib in ISEL. Additional studies are warranted to assess these biomarkers fully for the identification of patients most likely to benefit from gefitinib treatment.

Supported in part by AstraZeneca; a National Cancer Institute-International Union Aganist Cancer Traslational Cancer Research Fellowship, funded by the National Cancer Institute (R.D.); and by Bristol-Myers Squibb and Pfizer (A.C.).

Presented in part at the Annual Meeting of the American Association for Cancer Research-National Cancer Institute-European Organisation for Research and Treatment of Cancer, Philadelphia, PA, November 14-18, 2005.

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

Related Correspondence

  • EGFR Expression and Mutational Analysis As a Predictive Test
    Dan J. Raz and David M. Jablons
    JCO 2007 25: 2144 [Full Text]


This article has been cited by other articles:


Home page
 JNCI J Natl Cancer InstHome page
S. E. Taube, G. M. Clark, J. E. Dancey, L. M. McShane, C. C. Sigman, and S. I. Gutman
A Perspective on Challenges and Issues in Biomarker Development and Drug and Biomarker Codevelopment
J Natl Cancer Inst, November 4, 2009; 101(21): 1453 - 1463.
[Abstract] [Full Text] [PDF]

Home page
 Therapeutic Advances in Medical OncologyHome page
N. Peled, K. Yoshida, M. W. Wynes, and F. R. Hirsch
Review: Predictive and prognostic markers for epidermal growth factor receptor inhibitor therapy in non-small cell lung cancer
Therapeutic Advances in Medical Oncology, November 1, 2009; 1(3): 137 - 144.
[Abstract] [PDF]

Home page
 J. Clin. Pathol.Home page
M Varella-Garcia, J Diebold, D A Eberhard, K Geenen, A Hirschmann, M Kockx, I Nagelmeier, J Ruschoff, M Schmitt, S Arbogast, et al.
EGFR fluorescence in situ hybridisation assay: guidelines for application to non-small-cell lung cancer
J. Clin. Pathol., November 1, 2009; 62(11): 970 - 977.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. M. Sholl, B. Y. Yeap, A. J. Iafrate, A. J. Holmes-Tisch, Y.-P. Chou, M.-T. Wu, Y.-G. Goan, L. Su, E. Benedettini, J. Yu, et al.
Lung Adenocarcinoma with EGFR Amplification Has Distinct Clinicopathologic and Molecular Features in Never-Smokers
Cancer Res., November 1, 2009; 69(21): 8341 - 8348.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
T. S. Mok, Y.-L. Wu, S. Thongprasert, C.-H. Yang, D.-T. Chu, N. Saijo, P. Sunpaweravong, B. Han, B. Margono, Y. Ichinose, et al.
Gefitinib or Carboplatin-Paclitaxel in Pulmonary Adenocarcinoma
N. Engl. J. Med., September 3, 2009; 361(10): 947 - 957.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R. S. Finn, M. F. Press, J. Dering, M. Arbushites, M. Koehler, C. Oliva, L. S. Williams, and A. Di Leo
Estrogen Receptor, Progesterone Receptor, Human Epidermal Growth Factor Receptor 2 (HER2), and Epidermal Growth Factor Receptor Expression and Benefit From Lapatinib in a Randomized Trial of Paclitaxel With Lapatinib or Placebo As First-Line Treatment in HER2-Negative or Unknown Metastatic Breast Cancer
J. Clin. Oncol., August 20, 2009; 27(24): 3908 - 3915.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. Horn and A. Sandler
Epidermal Growth Factor Receptor Inhibitors and Antiangiogenic Agents for the Treatment of Non-Small Cell Lung Cancer
Clin. Cancer Res., August 15, 2009; 15(16): 5040 - 5048.
[Abstract] [Full Text] [PDF]

Home page
 Anticancer ResHome page
M. PESEK, L. BENESOVA, B. BELSANOVA, P. MUKENSNABL, F. BRUHA, and M. MINARIK
Dominance of EGFR and Insignificant KRAS Mutations in Prediction of Tyrosine-kinase Therapy for NSCLC Patients Stratified by Tumor Subtype and Smoking Status
Anticancer Res, July 1, 2009; 29(7): 2767 - 2773.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
G. Goss, D. Ferry, R. Wierzbicki, S. A. Laurie, J. Thompson, B. Biesma, F. R. Hirsch, M. Varella-Garcia, E. Duffield, O. U. Ataman, et al.
Randomized Phase II Study of Gefitinib Compared With Placebo in Chemotherapy-Naive Patients With Advanced Non-Small-Cell Lung Cancer and Poor Performance Status
J. Clin. Oncol., May 1, 2009; 27(13): 2253 - 2260.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
G. J. Riely, J. Marks, and W. Pao
KRAS Mutations in Non-Small Cell Lung Cancer
Proceedings of the ATS, April 15, 2009; 6(2): 201 - 205.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
F. Cappuzzo, A. Marchetti, M. Skokan, E. Rossi, S. Gajapathy, L. Felicioni, M. del Grammastro, M. G. Sciarrotta, F. Buttitta, M. Incarbone, et al.
Increased MET Gene Copy Number Negatively Affects Survival of Surgically Resected Non-Small-Cell Lung Cancer Patients
J. Clin. Oncol., April 1, 2009; 27(10): 1667 - 1674.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
S. E. Witta, R. Dziadziuszko, K. Yoshida, K. Hedman, M. Varella-Garcia, P. A. Bunn Jr, and F. R. Hirsch
ErbB-3 expression is associated with E-cadherin and their coexpression restores response to gefitinib in non-small-cell lung cancer (NSCLC)
Ann. Onc., April 1, 2009; 20(4): 689 - 695.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. G. Pernas, C. T. Allen, M. E. Winters, B. Yan, J. Friedman, B. Dabir, K. Saigal, G. S. Mundinger, X. Xu, J. C. Morris, et al.
Proteomic Signatures of Epidermal Growth Factor Receptor and Survival Signal Pathways Correspond to Gefitinib Sensitivity in Head and Neck Cancer
Clin. Cancer Res., April 1, 2009; 15(7): 2361 - 2372.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
H. Jiang
Overview of Gefitinib in Non-small Cell Lung Cancer: An Asian Perspective
Jpn. J. Clin. Oncol., March 1, 2009; 39(3): 137 - 150.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
F. Cappuzzo, P. A. Janne, M. Skokan, G. Finocchiaro, E. Rossi, C. Ligorio, P. A. Zucali, L. Terracciano, L. Toschi, M. Roncalli, et al.
MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients
Ann. Onc., February 1, 2009; 20(2): 298 - 304.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
M. A. Pantaleo, M. Nannini, A. Maleddu, S. Fanti, C. Nanni, S. Boschi, F. Lodi, G. Nicoletti, L. Landuzzi, P. L. Lollini, et al.
Experimental results and related clinical implications of PET detection of epidermal growth factor receptor (EGFr) in cancer
Ann. Onc., February 1, 2009; 20(2): 213 - 226.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
F. R. Hirsch, R. S. Herbst, C. Olsen, K. Chansky, J. Crowley, K. Kelly, W. A. Franklin, P. A. Bunn Jr, M. Varella-Garcia, and D. R. Gandara
In Reply
J. Clin. Oncol., January 20, 2009; 27(3): 465 - 467.
[Full Text] [PDF]

Home page
 Anticancer ResHome page
A. OOI, S. SUZUKI, K. NAKAZAWA, J. ITAKURA, I. IMOTO, H. NAKAMURA, and Y. DOBASHI
Gene Amplification of Myc and its Coamplification with ERBB2 and EGFR in Gallbladder Adenocarcinoma
Anticancer Res, January 1, 2009; 29(1): 19 - 26.
[Abstract] [Full Text] [PDF]

Home page
 Am Soc Clin Oncol Ed BookHome page
M. A. Socinski
What Guides Decisions about the Use of Epidermal Growth Factor Receptor Antibody or Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Advanced Non-small Cell Lung Cancer?
ASCO Educational Book, January 1, 2009; 2009(1): 436 - 443.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
T. Takano, T. Fukui, Y. Ohe, K. Tsuta, S. Yamamoto, H. Nokihara, N. Yamamoto, I. Sekine, H. Kunitoh, K. Furuta, et al.
EGFR Mutations Predict Survival Benefit From Gefitinib in Patients With Advanced Lung Adenocarcinoma: A Historical Comparison of Patients Treated Before and After Gefitinib Approval in Japan
J. Clin. Oncol., December 1, 2008; 26(34): 5589 - 5595.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
G. J. Riely and M. Ladanyi
KRAS Mutations: An Old Oncogene Becomes a New Predictive Biomarker
J. Mol. Diagn., November 1, 2008; 10(6): 493 - 495.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
K. Kelly, M. W. Redman, and D. R. Gandara
In Reply
J. Clin. Oncol., October 10, 2008; 26(29): 4850 - 4851.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. R. Hirsch, M. Varella-Garcia, R. Dziadziuszko, Y. Xiao, S. Gajapathy, M. Skokan, M. Lin, V. O'Neill, and P. A. Bunn Jr.
Fluorescence In situ Hybridization Subgroup Analysis of TRIBUTE, a Phase III Trial of Erlotinib Plus Carboplatin and Paclitaxel in Non-Small Cell Lung Cancer
Clin. Cancer Res., October 1, 2008; 14(19): 6317 - 6323.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
L. Crino, F. Cappuzzo, P. Zatloukal, M. Reck, M. Pesek, J. C. Thompson, H. E.R. Ford, F. R. Hirsch, M. Varella-Garcia, S. Ghiorghiu, et al.
Gefitinib Versus Vinorelbine in Chemotherapy-Naive Elderly Patients With Advanced Non-Small-Cell Lung Cancer (INVITE): A Randomized, Phase II Study
J. Clin. Oncol., September 10, 2008; 26(26): 4253 - 4260.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. L. Van Dyke, M. L. Cote, G. M. Prysak, G. B. Claeys, A. S. Wenzlaff, V. C. Murphy, F. Lonardo, and A. G. Schwartz
COX-2/EGFR expression and survival among women with adenocarcinoma of the lung
Carcinogenesis, September 1, 2008; 29(9): 1781 - 1787.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
T. E. Stinchcombe and M. A. Socinski
Gefitinib in Advanced Non-Small Cell Lung Cancer: Does It Deserve a Second Chance?
Oncologist, September 1, 2008; 13(9): 933 - 944.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M.-J. Ahn, B.-B. Park, J. S. Ahn, S. W. Kim, H.-T. Kim, J. S. Lee, J. H. Kang, J. Y. Cho, H. S. Song, S. H. Park, et al.
Are There Any Ethnic Differences in Molecular Predictors of Erlotinib Efficacy in Advanced Non-Small Cell Lung Cancer?
Clin. Cancer Res., June 15, 2008; 14(12): 3860 - 3866.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Felip, F. Rojo, M. Reck, A. Heller, B. Klughammer, G. Sala, S. Cedres, S. Peralta, H. Maacke, D. Foernzler, et al.
A Phase II Pharmacodynamic Study of Erlotinib in Patients with Advanced Non-Small Cell Lung Cancer Previously Treated with Platinum-Based Chemotherapy
Clin. Cancer Res., June 15, 2008; 14(12): 3867 - 3874.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Kudoh, H. Kato, Y. Nishiwaki, M. Fukuoka, K. Nakata, Y. Ichinose, M. Tsuboi, S. Yokota, K. Nakagawa, M. Suga, et al.
Interstitial Lung Disease in Japanese Patients with Lung Cancer: A Cohort and Nested Case-Control Study
Am. J. Respir. Crit. Care Med., June 15, 2008; 177(12): 1348 - 1357.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C.-H. Yang, C.-J. Yu, J.-Y. Shih, Y.-C. Chang, F.-C. Hu, M.-C. Tsai, K.-Y. Chen, Z.-Z. Lin, C.-J. Huang, C.-T. Shun, et al.
Specific EGFR Mutations Predict Treatment Outcome of Stage IIIB/IV Patients With Chemotherapy-Naive Non-Small-Cell Lung Cancer Receiving First-Line Gefitinib Monotherapy
J. Clin. Oncol., June 1, 2008; 26(16): 2745 - 2753.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
G. J. Weiss, L. T. Bemis, E. Nakajima, M. Sugita, D. K. Birks, W. A. Robinson, M. Varella-Garcia, P. A. Bunn Jr, J. Haney, B. A. Helfrich, et al.
EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines
Ann. Onc., June 1, 2008; 19(6): 1053 - 1059.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
K. Kelly, K. Chansky, L. E. Gaspar, K. S. Albain, J. Jett, Y. C. Ung, D. H.M. Lau, J. J. Crowley, and D. R. Gandara
Phase III Trial of Maintenance Gefitinib or Placebo After Concurrent Chemoradiotherapy and Docetaxel Consolidation in Inoperable Stage III Non-Small-Cell Lung Cancer: SWOG S0023
J. Clin. Oncol., May 20, 2008; 26(15): 2450 - 2456.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
F. A. Shepherd
Molecular Selection of Patients for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer With Epidermal Growth Factor Inhibitors: Not Quite Ready for Prime Time
J. Clin. Oncol., May 20, 2008; 26(15): 2426 - 2427.
[Full Text] [PDF]

Home page
 ChestHome page
P. S. Hodkinson, A. MacKinnon, and T. Sethi
Targeting Growth Factors in Lung Cancer
Chest, May 1, 2008; 133(5): 1209 - 1216.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Jimeno, A. C. Tan, J. Coffa, N.V. Rajeshkumar, P. Kulesza, B. Rubio-Viqueira, J. Wheelhouse, B. Diosdado, W. A. Messersmith, C. Iacobuzio-Donahue, et al.
Coordinated Epidermal Growth Factor Receptor Pathway Gene Overexpression Predicts Epidermal Growth Factor Receptor Inhibitor Sensitivity in Pancreatic Cancer
Cancer Res., April 15, 2008; 68(8): 2841 - 2849.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Yatabe, T. Takahashi, and T. Mitsudomi
Epidermal Growth Factor Receptor Gene Amplification Is Acquired in Association with Tumor Progression of EGFR-Mutated Lung Cancer
Cancer Res., April 1, 2008; 68(7): 2106 - 2111.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
F. Ciardiello and G. Tortora
EGFR Antagonists in Cancer Treatment
N. Engl. J. Med., March 13, 2008; 358(11): 1160 - 1174.
[Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
F. Pinter, J. Papay, A. Almasi, Z. Sapi, E. Szabo, M. Kanya, A. Tamasi, B. Jori, E. Varkondi, J. Moldvay, et al.
Epidermal Growth Factor Receptor (EGFR) High Gene Copy Number and Activating Mutations in Lung Adenocarcinomas Are Not Consistently Accompanied by Positivity for EGFR Protein by Standard Immunohistochemistry
J. Mol. Diagn., March 1, 2008; 10(2): 160 - 168.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. C. Black, G. A. Brown, T. Inamoto, M. Shrader, A. Arora, A. O. Siefker-Radtke, L. Adam, D. Theodorescu, X. Wu, M. F. Munsell, et al.
Sensitivity to Epidermal Growth Factor Receptor Inhibitor Requires E-Cadherin Expression in Urothelial Carcinoma Cells
Clin. Cancer Res., March 1, 2008; 14(5): 1478 - 1486.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. A. Eberhard, G. Giaccone, and B. E. Johnson
Biomarkers of Response to Epidermal Growth Factor Receptor Inhibitors in Non-Small-Cell Lung Cancer Working Group: Standardization for Use in the Clinical Trial Setting
J. Clin. Oncol., February 20, 2008; 26(6): 983 - 994.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
P. A. Bunn Jr. and N. Thatcher
Conclusion
Oncologist, January 1, 2008; 13(suppl_1): 37 - 46.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. A. Butts, D. Bodkin, E. L. Middleman, C. W. Englund, D. Ellison, Y. Alam, H. Kreisman, P. Graze, J. Maher, H. J. Ross, et al.
Randomized Phase II Study of Gemcitabine Plus Cisplatin or Carboplatin, With or Without Cetuximab, As First-Line Therapy for Patients With Advanced or Metastatic Non-Small-Cell Lung Cancer
J. Clin. Oncol., December 20, 2007; 25(36): 5777 - 5784.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W. Liu, X. Wu, W. Zhang, R. C. Montenegro, D. L. Fackenthal, J. A. Spitz, L. M. Huff, F. Innocenti, S. Das, E. H. Cook, Jr., et al.
Relationship of EGFR Mutations, Expression, Amplification, and Polymorphisms to Epidermal Growth Factor Receptor Inhibitors in the NCI60 Cell Lines
Clin. Cancer Res., November 15, 2007; 13(22): 6788 - 6795.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Heuser, B. Argiropoulos, F. Kuchenbauer, E. Yung, J. Piper, S. Fung, R. F. Schlenk, K. Dohner, T. Hinrichsen, C. Rudolph, et al.
MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML
Blood, September 1, 2007; 110(5): 1639 - 1647.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. W. Ryan, B. H. Goldman, P. N. Lara Jr, P. C. Mack, T. M. Beer, C. M. Tangen, D. Lemmon, C.-X. Pan, H. A. Drabkin, and E. D. Crawford
Sorafenib With Interferon Alfa-2b As First-Line Treatment of Advanced Renal Carcinoma: A Phase II Study of the Southwest Oncology Group
J. Clin. Oncol., August 1, 2007; 25(22): 3296 - 3301.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
M. V. Karamouzis, J. R. Grandis, and A. Argiris
Therapies Directed Against Epidermal Growth Factor Receptor in Aerodigestive Carcinomas
JAMA, July 4, 2007; 298(1): 70 - 82.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
C. Gridelli, M. A. Bareschino, C. Schettino, A. Rossi, P. Maione, and F. Ciardiello
Erlotinib in Non-Small Cell Lung Cancer Treatment: Current Status and Future Development
Oncologist, July 1, 2007; 12(7): 840 - 849.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
P. A. Bunn Jr
Can Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Be Overcome by Different Small-Molecule Tyrosine Kinase Inhibitors?
J. Clin. Oncol., June 20, 2007; 25(18): 2504 - 2505.
[Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
M.-S. Tsao, G. Liu, and F. A. Shepherd
Serum Proteomic Classifier for Predicting Response to Epidermal Growth Factor Receptor Inhibitor Therapy: Have We Built a Better Mousetrap?
J Natl Cancer Inst, June 6, 2007; 99(11): 826 - 827.
[Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
F. Taguchi, B. Solomon, V. Gregorc, H. Roder, R. Gray, K. Kasahara, M. Nishio, J. Brahmer, A. Spreafico, V. Ludovini, et al.
Mass Spectrometry to Classify Non-Small-Cell Lung Cancer Patients for Clinical Outcome After Treatment With Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Multicohort Cross-Institutional Study
J Natl Cancer Inst, June 6, 2007; 99(11): 838 - 846.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
F. Cappuzzo, C. Ligorio, P. A. Janne, L. Toschi, E. Rossi, R. Trisolini, D. Paioli, A. J. Holmes, E. Magrini, G. Finocchiaro, et al.
Prospective Study of Gefitinib in Epidermal Growth Factor Receptor Fluorescence In Situ Hybridization-Positive/Phospho-Akt-Positive or Never Smoker Patients With Advanced Non-Small-Cell Lung Cancer: The ONCOBELL Trial
J. Clin. Oncol., June 1, 2007; 25(16): 2248 - 2255.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. J. Raz and D. M. Jablons
EGFR Expression and Mutational Analysis As a Predictive Test
J. Clin. Oncol., May 20, 2007; 25(15): 2144 - 2144.
[Full Text] [PDF]

Home page
 JCOHome page
F. R. Hirsch, M. Varella-Garcia, W. A. Franklin, R. Dziadziuszko, P. A. Bunn Jr, C. Watkins, and B. Holloway
In Reply
J. Clin. Oncol., May 20, 2007; 25(15): 2144 - 2145.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Massarelli, M. Varella-Garcia, X. Tang, A. C. Xavier, N. C. Ozburn, D. D. Liu, B. N. Bekele, R. S. Herbst, and I. I. Wistuba
KRAS Mutation Is an Important Predictor of Resistance to Therapy with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer
Clin. Cancer Res., May 15, 2007; 13(10): 2890 - 2896.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Dubey and C. A. Powell
Update in Lung Cancer 2006
Am. J. Respir. Crit. Care Med., May 1, 2007; 175(9): 868 - 874.
[Full Text] [PDF]

Home page
 Ann OncolHome page
F. Hirsch, M Varella-Garcia, F Cappuzzo, J McCoy, L Bemis, A. Xavier, R Dziadziuszko, P Gumerlock, K Chansky, H West, et al.
Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib
Ann. Onc., April 1, 2007; 18(4): 752 - 760.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
N van Zandwijk and M. van de Vijver
clairvoyance or reliable prediction of the future?
Ann. Onc., March 1, 2007; 18(3): 407 - 408.
[Full Text] [PDF]

Home page
 JCOHome page
L. V. Sequist, D. W. Bell, T. J. Lynch, and D. A. Haber
Molecular Predictors of Response to Epidermal Growth Factor Receptor Antagonists in Non-Small-Cell Lung Cancer
J. Clin. Oncol., February 10, 2007; 25(5): 587 - 595.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
L. Toschi and F. Cappuzzo
Understanding the New Genetics of Responsiveness to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
Oncologist, February 1, 2007; 12(2): 211 - 220.
[Abstract] [Full Text] [PDF]


About
JCO		 Editorial
Roster		 Advertising
Information		 Librarians &
Institutions		 Rights &
Permissions		 PDA Services

Copyright © 2006 by the American Society of Clinical Oncology, Online ISSN: 1527-7755. Print ISSN: 0732-183X
Terms and Conditions of Use
  HighWire Press HighWire Press™ assists in the publication of JCO Online