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Originally published as JCO Early Release 10.1200/JCO.2006.07.2462 on November 6 2006

Journal of Clinical Oncology, Vol 24, No 34 (December 1), 2006: pp. 5395-5402
© 2006 American Society of Clinical Oncology.

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Validation of a Self-Administered, Computerized Tool for Collecting and Displaying the Family History of Cancer

Louise S. Acheson, Stephen J. Zyzanski, Kurt C. Stange, Amy Deptowicz, Georgia L. Wiesner

From the Department of Family Medicine, Comprehensive Cancer Center, Department of Reproductive Biology, Department of Epidemiology and Biostatistics, Department of Sociology, Department of Genetics, and Center for Human Genetics, Case Western Reserve University; and University Hospitals of Cleveland, Cleveland, OH

Address reprint requests to Louise S. Acheson, MD, MS, Department of Family Medicine, Case Western Reserve University and University Hospitals of Cleveland LC 5036, 11100 Euclid Ave, Cleveland, OH 44106-5036; e-mail: louise.acheson{at}case.edu

PURPOSE: A detailed family history is important for cancer risk assessment, but obtaining it is time consuming and infrequently accomplished in practice. The Genetic Risk Easy Assessment Tool (GREAT) conducts a computer-administered family history interview and immediately generates a pedigree diagram in digital form. The purpose of this study was to validate family cancer histories produced by patients using the computer tool in comparison with pedigrees made by genetic counselors.

METHODS: Patients scheduled for genetics consultation recorded their family histories using the GREAT, separate from their genetic counseling session. The presence of each relative; presence, type, and age at diagnosis of cancers; and cancer geneticist's risk assessment were compared for 120 pairs of pedigrees produced by counselors versus computer tool.

RESULTS: The automated telephone interview took a mean of 33.5 minutes and was highly acceptable to respondents. Ninety-four percent of first-degree relatives, 67% of second-degree relatives, and 38% of third-degree relatives were identical on paired pedigrees; computer-generated pedigrees included additional relatives. Sixty-three percent of all cancers were identified by both family histories, with 90% agreement on the type of cancer. There was very good agreement ({kappa} = 0.70; correlation = 0.77) between the geneticist's breast cancer risk assessments based on computer versus counselors' pedigrees. In a subsample of 61 users, test-retest reliability for the computer-administered questionnaire was high ({phi} = 0.94 for cancers in first-degree and {phi} = 0.91 in second-degree relatives).

CONCLUSION: The GREAT computer-administered questionnaire provides an acceptable, reliable, and valid way of collecting an unverified but extensive family history of cancer and displaying it as a pedigree, in an entirely automated process.

published online ahead of print at www.jco.org on November 6, 2006.

Supported by the American Cancer Society, Cuyahoga Branch, Pilot Research (L.S.A. and G.L.W.); the Behavioral Measurement Core of the Case Comprehensive Cancer Center (S.J.Z.); the National Cancer Institute: K-12 postdoctoral fellowship (L.S.A.); K07 career development award CA86958 (L.S.A.); K24 mid-career development award (K.C.S.); an HRSA Development of Departments of Family Medicine training grant; and the Center for Human Genetics at University Hospitals of Cleveland.

Presented in part at the American Society of Human Genetics Annual Meeting, October 17, 2002, Baltimore, MD; and American College of Medical Genetics Annual Meeting, March 13-17, 2002, New Orleans, LA.

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.






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Copyright © 2006 by the American Society of Clinical Oncology, Online ISSN: 1527-7755. Print ISSN: 0732-183X
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