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Role of Cytokine Therapy in 2006 and Beyond for Metastatic Renal Cell Cancer

Marina Parton, Martin Gore, Tim Eisen

From the Department of Medicine, Royal Marsden Hospital, London, United Kingdom

Address reprint requests to Tim Eisen, PhD, Cancer Research UK, Cambridge Research Institute, Robinson Way, Cambridge CB2 2RE, United Kingdom; e-mail: tgqe2{at}cam.ac.uk

Metastatic renal cell cancer (mRCC) has a long history as a disease with poor prognosis and limited therapeutic options. Immunotherapy has been the mainstay of treatment since the 1980s, and there have been a number of largely phase II studies examining various schedules of interferon-alpha and interleukin-2 based treatments. With the development of molecular targeted drugs the armentarium against mRCC has significantly expanded and cytokine treatments should be only directed at those most likely to benefit with durable remissions and prolonged survival.

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.

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