Advertisement
Journal of Clinical Oncology  
Search for:
Limit by:
  Browse by Subject or Issue
Home Search or Browse JCO My JCO Subscriptions Customer Service Site Map

Originally published as JCO Early Release 10.1200/JCO.2005.03.6038 on January 17 2006

Journal of Clinical Oncology, Vol 24, No 6 (February 20), 2006: pp. 878-883
© 2006 American Society of Clinical Oncology.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Save to my personal folders
Right arrow Download to citation manager
Right arrowRights & Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Redston, M.
Right arrow Articles by Bertagnolli, M. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Redston, M.
Right arrow Articles by Bertagnolli, M. M.
Related Articles
Right arrowRelated Editorial
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Analysis of Micrometastatic Disease in Sentinel Lymph Nodes From Resectable Colon Cancer: Results of Cancer and Leukemia Group B Trial 80001

Mark Redston, Carolyn C. Compton, Brent W. Miedema, Donna Niedzwiecki, Jeannette M. Dowell, Scott D. Jewell, James M. Fleshman, Jiri Bem, Robert J. Mayer, Monica M. Bertagnolli

From the Brigham and Women's Hospital; Dana-Farber Cancer Institute, Boston, MA; University of Missouri/Ellis Fischel Cancer Center, Columbia; Washington University Medical Center, St Louis, MO; Cancer and Leukemia Group B Statistical Center, Duke University, Durham, NC; Ohio State University, Columbus, OH; State University of New York Upstate Medical University and Veteran's Administration Medical Center, Syracuse, NY; and McGill University, Montreal, Quebec, Canada

Address reprint requests to Monica M. Bertagnolli, MD, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; e-mail: mbertagnolli{at}partners.org

PURPOSE: To determine whether sentinel lymph node (LN) sampling (SLNS) could reduce the number of nodes required to characterize micrometastatic disease (MMD) in patients with potentially curable colon cancer.

PATIENTS AND METHODS: Cancer and Leukemia Group B 80001 was a study to determine whether SLNS could identify a subset of LNs that predicted the status of the nodal basin for resectable colon cancer and, therefore, could be extensively evaluated for the presence of micrometastases. Patients enrolled onto this study underwent SLNS after injection of 1% isosulfan blue, and both sentinel nodes (SNs) and non-SNs obtained during primary tumor resection were sectioned at multiple levels and stained using anti–carcinoembryonic antigen and anticytokeratin antibodies.

RESULTS: Using standard histopathology, SNs failed to predict the presence of nodal disease in 13 (54%) of 24 node-positive patients. Immunostains were performed for patients whose LNs were negative by standard histopathology. Depending on the immunohistochemical criteria used to assign LN positivity, SN examination resulted in either an unacceptably high false-positive rate (20%) or a low sensitivity for detection of MMD (40%).

CONCLUSION: By examining both SNs and non-SNs, this multi-institutional study showed that SNs did not accurately predict the presence of either conventionally defined nodal metastases or MMD. As a result, SLNS is not a useful technique for the study of MMD in patients with colon cancer.

Supported in part by Grant No. CA31946 from the National Cancer Institute to the Cancer and Leukemia Group B (CALGB) and Grant No. CA59594 to the CALGB Surgery Committee.

Presented at the 40th Annual Meeting of the American Society of Clinical Oncology, New Orleans, LA, June 5-8, 2004.

The contents of this manuscript are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute.

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

Related Editorial

  • Is There Clinical Value to Sentinel Lymph Node Sampling in Colon Cancer?
    Robert P. Sticca
    JCO 2006 24: 841-842 [Full Text]


This article has been cited by other articles:


Home page
Ann. Surg. Oncol.Home page
R. A. Cahill, S. Perretta, J. Leroy, B. Dallemagne, and J. Marescaux
Lymphatic Mapping and Sentinel Node Biopsy in the Colonic Mesentery by Natural Orifice Transluminal Endoscopic Surgery (NOTES)
Ann. Surg. Oncol., October 1, 2008; 15(10): 2677 - 2683.
[Abstract] [Full Text] [PDF]


Home page
Ann. Surg. Oncol.Home page
M. Nicholl and A. J. Bilchik
Is Routine Use of Sentinel Node Biopsy Justified in Colon Cancer?
Ann. Surg. Oncol., January 1, 2008; 15(1): 1 - 3.
[Full Text] [PDF]


Home page
Ann. Surg. Oncol.Home page
S. J. Lim, B. W. Feig, H. Wang, K. K. Hunt, M. A. Rodriguez-Bigas, J. M. Skibber, V. Ellis, K. Cleary, and G. J. Chang
Sentinel Lymph Node Evaluation Does Not Improve Staging Accuracy in Colon Cancer
Ann. Surg. Oncol., January 1, 2008; 15(1): 46 - 51.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
R. R. Turner, C. Li, and C. C. Compton
Newer Pathologic Assessment Techniques for Colorectal Carcinoma
Clin. Cancer Res., November 15, 2007; 13(22): 6871s - 6876s.
[Abstract] [Full Text] [PDF]


Home page
J. Mol. Diagn.Home page
D. G. Nicastri, J. T. Doucette, T. E. Godfrey, and S. J. Hughes
Is Occult Lymph Node Disease in Colorectal Cancer Patients Clinically Significant?: A Review of the Relevant Literature
J. Mol. Diagn., November 1, 2007; 9(5): 563 - 571.
[Abstract] [Full Text] [PDF]


Home page
Ann. Surg. Oncol.Home page
D. Iddings, A. Ahmad, D. Elashoff, and A. Bilchik
The Prognostic Effect of Micrometastases in Previously Staged Lymph Node Negative (N0) Colorectal Carcinoma: A Meta-analysis
Ann. Surg. Oncol., November 1, 2006; 13(11): 1386 - 1392.
[Abstract] [Full Text] [PDF]


Home page
CA Cancer J ClinHome page
S. L. Chen, D. M. Iddings, R. P. Scheri, and A. J. Bilchik
Lymphatic Mapping and Sentinel Node Analysis: Current Concepts and Applications
CA Cancer J Clin, September 1, 2006; 56(5): 292 - 309.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
M. Pocard, M. Van den Eynde, D. Goere, V. Boige, and D. Malka
Sentinel Lymph Node Sampling and Analysis in Colon Cancer: What Is the Question?
J. Clin. Oncol., August 1, 2006; 24(22): 3712 - 3713.
[Full Text] [PDF]


Home page
JCOHome page
M. Redston and M. M. Bertagnolli
In Reply
J. Clin. Oncol., August 1, 2006; 24(22): 3713 - 3714.
[Full Text] [PDF]


Home page
Arch SurgHome page
A. J. Bilchik, M. DiNome, S. Saha, R. R. Turner, D. Wiese, M. McCarter, D. S. B. Hoon, and D. L. Morton
Prospective Multicenter Trial of Staging Adequacy in Colon Cancer: Preliminary Results
Arch Surg, June 1, 2006; 141(6): 527 - 534.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
R. M. Goldberg, D. Niedzwiecki, M. Bertagnolli, A. W. Blackstock, J. E. Tepper, and R. J. Mayer
Cancer and leukemia group B gastrointestinal cancer committee.
Clin. Cancer Res., June 1, 2006; 12(11): 3589s - 3595s.
[Abstract] [Full Text] [PDF]



About
JCO
 Editorial
Roster
 Advertising
Information
 Librarians &
Institutions
 Rights &
Permissions
 PDA Services

Copyright © 2006 by the American Society of Clinical Oncology, Online ISSN: 1527-7755. Print ISSN: 0732-183X
Terms and Conditions of Use
  HighWire Press HighWire Press™ assists in the publication of JCO Online