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Diffusely Infiltrative Low-Grade Gliomas in Adults

From the Departments of Neurosurgery and Neuro-oncology and the Brain Tumor Center, The University of Texas M.D. Anderson Cancer Center, Houston, TX

Address reprint requests to Frederick F. Lang, MD, Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; e-mail: flang{at}mdanderson.org

Diffusely infiltrating low-grade gliomas (LGGs) include astrocytomas, oligodendrogliomas, and mixed oligoastrocytomas (WHO grade 2). Due to the routine use of magnetic resonance imaging, there is an increasing need to formulate treatment guidelines for patients with LGGs. However, there is little consensus about the optimal treatment strategy for diffusely infiltrative LGGs, and the clinical management of LGGs is one of the most controversial areas in neurooncology. Although the standard of care has not been established, several randomized trials are beginning to provide some answers. Furthermore, laboratory correlative studies are defining subsets of LGG that may identify patients with better prognoses and increased chance of responding to therapy. This article reviews the most recent data regarding the treatment of LGG, emphasizing evidenced based approaches from current clinical trials.

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.

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