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Phase II Trial of Bevacizumab and Erlotinib in Carcinomas of Unknown Primary Site: The Minnie Pearl Cancer Research Network

John D. Hainsworth, David R. Spigel, Cindy Farley, Dana S. Thompson, Dianna L. Shipley, F. Anthony Greco

From the Sarah Cannon Research Institute; and Tennessee Oncology, PLLC, Nashville, TN

Address reprint requests to John D. Hainsworth, MD, Sarah Cannon Research Institute, 250 25th Ave North, Suite 220, Nashville, TN 37203; e-mail: jhainsworth{at}tnonc.com

Purpose Treatment remains poor for many patients with carcinoma of unknown primary site (CUP), and no effective second-line treatment has been identified. Combination inhibition of vascular endothelial growth factor (VEGF) and the epidermal growth factor receptor (EGFR) with bevacizumab and erlotinib has proved efficacious and well tolerated in other solid tumors. We therefore have evaluated the efficacy and toxicity of this combination in patients with CUP.

Patients and Methods Patients with CUP who either had received previous chemotherapy or were previously untreated with poor-prognosis clinical features were eligible for this study. All patients received bevacizumab 10 mg/kg IV every 2 weeks, along with erlotinib 150 mg orally daily. Patients were re-evaluated after 8 weeks of treatment; those with objective response or stable disease continued treatment until disease progression.

Results Forty-seven (92%) of 51 patients received at least 8 weeks of treatment. Five patients (10%) had partial responses, and 29 patients (61%) had stable disease as the best response. The median survival for the entire group was 7.4 months, with 33% of patients alive at 1 year. This regimen was well tolerated by most patients.

Conclusion The combination of bevacizumab and erlotinib has substantial activity in the treatment of patients with CUP. The median survival is superior to survival previously reported with second-line chemotherapy, and is similar to the results of many first-line chemotherapy trials in this setting. This regimen merits further evaluation in patients with CUP.

Supported by grants from Genentech Inc and the Minnie Pearl Foundation.

Authors’ disclosures of potential conflicts of interest and author contributions are found at the end of this article.

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