Originally published as JCO Early Release 10.1200/JCO.2006.09.1041 on April 30 2007

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Phase I-II Trial of Prone Accelerated Intensity Modulated Radiation Therapy to the Breast to Optimally Spare Normal Tissue

Silvia C. Formenti, Daniela Gidea-Addeo, Judith D. Goldberg, Daniel F. Roses, Amber Guth, Barry S. Rosenstein, Keith J. DeWyngaert

From the Department of Radiation Oncology, Division of Biostatistics; and the Department of Surgery, New York University Cancer Institute and New York University School of Medicine, New York, NY

Address reprint requests to Silvia C. Formenti, MD, New York University School of Medicine, THI98, 566 First Ave, New York, NY 10016; e-mail: silvia.formenti{at}med.nyu.edu

Purpose To report the clinical feasibility of a trial of accelerated whole-breast intensity modulated radiotherapy, with the patient in prone position, optimally to spare the heart and lung.

Patients and Methods Patients with stages I or II breast cancer, excised by breast conserving surgery with negative margins, were eligible for this institutional review board–approved prospective trial. Computed tomography simulation was performed with the patient prone on a dedicated breast board, in the exact position used for treatment. A dose of 40.5 Gy, delivered at 2.7 Gy in 15 fractions, was prescribed to the index breast with an additional concomitant boost of 0.5 Gy delivered to the tumor bed, for a total dose of 48 Gy to the lumpectomy site. Physics constraints consisted of limiting 5% of the heart volume to receive 18 Gy and 10% of the ipsilateral lung volume to receive 20 Gy.

Results Between September 2003 and August 2005, 91 patients were enrolled on the study. Median length of follow-up was 12 months (range, 1 to 28 months). In all patients the technique was feasible and heart and lung sparing was achieved as prescribed by the protocol. Acute toxicities consisting mostly of reversible grades 1-2 skin dermatitis (67%) and fatigue (18%) occurred in 75 patients. One patient sustained a regional recurrence rapidly followed by distant metastases.

Conclusion Accelerated whole breast intensity modulated radiotherapy in the prone position is feasible and it permits a drastic reduction in the volume of lung and heart tissue exposed to significant radiation.

published online ahead of print at www.jco.org on April 30, 2007

Supported by Department of Defense Grant No. DAMD 17-01-1-0345 and a New York University Cancer Institute Core Grant.

Presented in part in poster format at the 49th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, October 27-November 1, 2007, Los Angeles, CA.

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.

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