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Identifying Stage III Colorectal Cancer Patients: The Influence of the Patient, Surgeon, and Pathologist

Eva Judith Ann Morris, Nicola Joanne Maughan, David Forman, Philip Quirke

From the Cancer Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds; Pathology and Tumour Biology, Leeds Institute for Molecular Medicine, University of Leeds, St James's University Hospital; and the Northern and Yorkshire Cancer Registry and Information Service, Cookridge Hospital, Leeds, United Kingdom

Address reprint requests to Eva Judith Ann Morris, BSc, PhD, Arthington House, Cookridge Hospital, Leeds, United Kingdom LS16 6QB; e-mail: eva.morris{at}nycris.leedsth.nhs.uk

Purpose Nodal yields from resected colorectal cancers vary greatly. This study sought to determine what patient, tumor, and management factors influence the number of nodes retrieved and to determine if the extent of lymphadenectomy affects stage allocation and influences survival.

Patients and Methods Retrospective study of the nodal yields of 7,062 surgically resected colorectal cancer patients for whom colorectal pathology minimum data sets had been collected. The percentage of patients diagnosed as stage III was compared across nodal yield categories. A threshold for an adequate lymphadenectomy was defined as retrieval of 12 nodes. Binary logistic regression was used to determine factors associated with obtaining an adequate lymphadenectomy.

Results Median nodal yields increased over the study period from 7 (interquartile range [IQR], 4 to 11) in 1995 to 13 (IQR 8 to 19) in 2003. There was no difference in yield by cancer site or sex, but yields were lower in older patients. Yields increased with increasing local invasion and stage of tumor. The percentage of patients diagnosed as stage III increased as yields increased. Five-year survival was lower in those patients who did not have an adequate lymphadenectomy. Adequate lymphadenectomy was significantly more likely in patients with advanced tumors and when the surgery and pathology was undertaken by a specialist. Older patients were significantly less likely to receive an adequate lymphadenectomy.

Conclusion Variations in nodal yield are due to idiosyncratic patient and tumor characteristics and differences in the quality of surgery and pathology undertaken. Adequate lymphadenectomy is essential to ensure correct stage allocation and optimal survival.

Supported by the National Translational Research Cancer Program (N.J.M.), the Pelican Cancer Foundation (E.J.A.M.), and Yorkshire Cancer Research (P.Q.).

Authors’ disclosures of potential conflicts of interest and author contributions are found at the end of this article.

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