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Diffusion Magnetic Resonance Imaging: A Biomarker for Treatment Response in Oncology

Daniel A. Hamstra, Alnawaz Rehemtulla, Brian D. Ross

From the Departments of Radiation Oncology, Radiology, and Biological Chemistry, and The Center for Molecular Imaging, University of Michigan Medical Center, Ann Arbor, MI

Address reprint requests to Daniel A. Hamstra, MD, PhD, 109 Zina Pitcher Pl, The Biomedical Sciences Research Building, A504, The University of Michigan Medical Center, Ann Arbor, MI 48109-2200; e-mail: dhamm{at}umich.edu

Imaging of response to oncology treatments, either on clinical protocol or as part of standard practice, is a complicated process that has evolved during the last 10 years due to the improvement of existing imaging technologies and the introduction of newer modalities. Diffusion magnetic resonance imaging is a technique that measures the mobility of water within tissues and, as such, may function as a surrogate marker for both tissue cellularity and response to treatment that occur earlier than usual measures of tumor response. This review highlights the development of this technique and the state of current clinical understanding of its utility.

Supported by National Institutes of Health Research Grants No. P01CA85878, R24CA83099, and P50CA093990.

A.R. and B.D.R. have a financial interest in the underlying technology (patent No. 6,567,684) discussed in this article. Furthermore, this technology is licensed to ImBio LLC, in which A.R. and B.D.R. have a financial interest.

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.

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