Originally published as JCO Early Release 10.1200/JCO.2006.08.7304 on January 29 2007

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Phase I Study of the Novel Epothilone Analog Ixabepilone (BMS-247550) in Patients With Advanced Solid Tumors and Lymphomas

Carol Aghajanian, Howard A. Burris, III, Suzanne Jones, David R. Spriggs, Marvin B. Cohen, Ronald Peck, Paul Sabbatini, Martee L. Hensley, F. Anthony Greco, Jakob Dupont, Owen A. O'Connor

From the Developmental Chemotherapy Service, Memorial Sloan-Kettering Cancer Center, New York, NY; Sarah Cannon Cancer Center, Nashville, TN; Bristol-Myers Squibb, Princeton, NJ; and Bristol-Myers Squibb Oncology, Wallingford, CT

Address reprint requests to Carol Aghajanian, MD, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021; e-mail: aghajanc{at}mskcc.org

Purpose To establish the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), safety, pharmacokinetics, and pharmacodynamics of ixabepilone when administered as a 1-hour infusion every 3 weeks to patients with advanced solid tumors or relapsed/refractory non-Hodgkin's lymphoma. Dosing schedules of 40 mg/m² and 50 mg/m² over 3 hours were also evaluated.

Patients and Methods Sixty-one patients were enrolled using an initial accelerated dose-escalation phase followed by a standard dose-escalation phase, with doses of ixabepilone ranging from 7.4 to 65 mg/m². The pharmacokinetics of ixabepilone and two of its chemical degradation products were evaluated. Plasma pharmacodynamics were evaluated for both 1- and 3-hour infusions using an assay that measures the amount of endogenous tubulin in peripheral-blood mononuclear cells that exists in the polymerized versus the unpolymerized state. Response evaluation was performed every 6 weeks.

Results The most common DLTs were neutropenia, stomatitis/pharyngitis, myalgia, and arthralgia. The MTD of ixabepilone as a 1-hour infusion every 3 weeks was established as 50 mg/m². The maximum plasma concentration and area under the plasma concentration time curve appeared to increase less than proportionally to dose. Durable objective responses were seen in eight patients, including two complete responses. Five of the responders had experienced treatment failure with a taxane.

Conclusion The recommended dose of ixabepilone for the initiation of phase II studies on the basis of these results is 50 mg/m² over 1 hour every 3 weeks. The promising efficacy and tolerability results demonstrated by ixabepilone in this study warrant its continued development.

published online ahead of print at www.jco.org on January 29, 2007.

Supported by Bristol-Myers Squibb, Princeton, NJ.

Presented in part in poster format at the 42nd Annual Meeting of the American Society of Clinical Oncology, June 2-6, 2006, Atlanta, GA.

Authors’ disclosures of potential conflicts of interest and author contributions are found at the end of this article.

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