Originally published as JCO Early Release 10.1200/JCO.2008.16.4681 on October 27 2008

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Randomized Comparison of Cooked and Noncooked Diets in Patients Undergoing Remission Induction Therapy for Acute Myeloid Leukemia

Alison Gardner, Gloria Mattiuzzi, Stefan Faderl, Gautam Borthakur, Guillermo Garcia-Manero, Sherry Pierce, Mark Brandt, Elihu Estey

From The University of Texas M. D. Anderson Cancer Center, Houston, TX

Corresponding author: Elihu Estey, MD, University of Washington Medical Center, Fred Hutchinson Cancer Research Institute, Seattle Cancer Care Alliance, 825 Eastlake Ave E, G3-200, Seattle WA 98109; e-mail: eestey{at}u.washington.edu

Purpose A neutropenic diet is often used to prevent infection in patients with acute myeloid leukemia (AML). Although such a diet potentially entails inconvenience, its value is uncertain.

Patients and Methods One hundred fifty-three patients admitted to a high-efficiency particulate air–filtered room (protected environment [PE]) to receive induction therapy for newly diagnosed AML were randomly assigned to a diet containing no raw fruits or vegetables (cooked diet) or to a diet containing fresh fruit and fresh vegetables (raw diet). Stratification was based on the patients’ early risk of mortality (ERM) score. All patients received antibacterial and antifungal prophylaxis and remained on study until they were discharged from the PE. The outcomes of principal interest were major infection (pneumonia, bacteremia, or fungemia) and death; if the true probability of either event was 20% on the cooked arm and 40% on the raw arm, then the probability that the cooked arm would be selected as superior was 83%.

Results Seventy-eight patients were randomly assigned to the cooked arm, and 75 were assigned to the raw arm. The two groups were similar with respect to age, ERM, chemotherapy received, and days at risk. Twenty-nine percent of patients in the cooked group and 35% of patients in the raw group developed a major infection (P = .60). Time to major infection and survival time were similar in the two groups. Fever of unknown origin occurred in 51% of the cooked group and 36% of the raw group.

Conclusion In patients treated in a PE, a neutropenic diet did not prevent major infection or death.

published online ahead of print at www.jco.org on October 27, 2008

Presented in part at the 32nd Annual Oncology Nursing Congress, April 24-27, 2007, Las Vegas, NV.

Authors’ disclosures of potential conflicts of interest and author contributions are found at the end of this article.

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