Originally published as JCO Early Release 10.1200/JCO.2009.22.3339 on April 13 2009

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The Childhood Cancer Survivor Study: A National Cancer Institute–Supported Resource for Outcome and Intervention Research

From the Departments of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN; International Epidemiology Institute; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD; Department of Pediatrics, University of Washington, Seattle, WA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati; Department of Pathology, OH State University School of Medicine, Columbus, OH; Department of Radiation Oncology, Stanford University Medical Center, Stanford; Department of Pediatrics, University of California at Los Angeles, Los Angeles, CA; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; Department of Pediatrics, Emory University, Atlanta, GA; Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Department of Pediatrics, University of Minnesota, Minneapolis, MN; Department of Neurology, Children's National Medical Center, Washington, DC; Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY; Departments of Radiation Physics and Cancer Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, TX; Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario; and Department of Public Health Sciences, University of Alberta School of Public Health, Edmonton, Alberta, Canada.

Corresponding author: Leslie L. Robison, PhD, Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 735, Memphis, TN 38105-2794; e-mail: les.robison{at}stjude.org.

Survival for childhood cancer has increased dramatically over the last 40 years with 5-year survival rates now approaching 80%. For many diagnostic groups, rapid increases in survival began in the 1970s with the broader introduction of multimodality approaches, often including combination chemotherapy with or without radiation therapy. With this increase in rates of survivorship has come the recognition that survivors are at risk for adverse health and quality-of-life outcomes, with risk being influenced by host-, disease-, and treatment-related factors. In 1994, the US National Cancer Institute funded the Childhood Cancer Survivor Study, a multi-institutional research initiative designed to establish a large and extensively characterized cohort of more than 14,000 5-year survivors of childhood and adolescent cancer diagnosed between 1970 and 1986. This ongoing study, which reflects the single most comprehensive body of information ever assembled on childhood and adolescent cancer survivors, provides a dynamic framework and resource to investigate current and future questions about childhood cancer survivors.

Written on behalf of the Steering Committee of the Childhood Cancer Survivor Study.

Supported by Grant No. U24 CA 55727 (L.L.R.) from the National Cancer Institute, Bethesda, MD, with additional support provided to St Jude Children's Research Hospital by the American Lebanese Syrian Associated Charities.

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.

Clinical Trials repository link available on JCO.org.

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