Originally published as JCO Early Release 10.1200/JCO.2008.20.3497 on August 3 2009

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Three-Dimensional Prostate Mapping Biopsy Has a Potentially Significant Impact on Prostate Cancer Management

From the Department of Radiology, Florida Hospital Celebration Health, Celebration; and Bostwick Laboratories, Orlando, FL.

Corresponding author: Gary Onik, MD, Department of Radiology, 400 Celebration Pl, Celebration Health/Florida, Celebration FL 34747; e-mail: onikcryo{at}aol.com.

Purpose To compare a new staging, three-dimensional prostate mapping biopsy (3D-PMB) method with traditional transrectal ultrasound (TRUS) biopsy and assess its possible impact on patient management.

Patients and Methods One hundred eighty patients with unilateral cancer on TRUS biopsy, who were considering conservative management, underwent restaging with 3D-PMB. The 3D-PMB was carried out transperineally using a brachytherapy grid under TRUS guidance. Biopsies were taken every 5 mm throughout the volume of the prostate, and labeling of the specimen coordinates allowed accurate reconstruction of the location and extent of a patient's cancer.

Results 3D-PMB obtained a median of 50 cores (standard deviation, ± 20.61). One hundred ten patients (61.1%) were positive bilaterally, and 41 patients (22.7%) had Gleason scores increased to 7 or higher. Thirty-six patients had negative results on 3D-PMB. Complications of 3D-PMB were self-limited and included 14 patients (7.7%) who required short-term indwelling catheter drainage and two patients with hematuria, one of whom required overnight bladder irrigation.

Conclusion 3D-PMB is a transperineal biopsy that can be safely used to accurately stage prostate cancer patients. At the present time, when patient management is increasingly based on the extent and characteristics of prostate cancer, 3D-PMB could have a profound effect on patient management.

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.

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