Journal of Clinical Oncology, Vol 3, 998-1004, Copyright © 1985 by American Society of Clinical Oncology
Sequential high-dose cytosine arabinoside-asparaginase treatment in advanced childhood leukemia
RJ Wells, J Feusner, R Devney, WG Woods, AJ Provisor, MS Cairo, LF Odom, J Nachman, GR Jones and LJ Ettinger
Sequential high-dose cytosine arabinoside (ara-C) and asparaginase were
given to 41 children age six months to 21 years of age with advanced
leukemia. Ten of 22 patients with acute lymphocytic leukemia (ALL) and
eight of 19 patients with acute nonlymphocytic leukemia (ANLL) obtained
complete remissions. The most significant toxicity seen was infection in 22
patients. In addition, patients given intrathecal chemotherapy within 24
hours of ara-C developed neurologic toxicity. The high response rate seen
in these patients with advanced leukemia indicates that a trial of this
regimen is warranted in children with less advanced ALL and ANLL.
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