Journal of Clinical Oncology, Vol 6, 173-177, Copyright © 1988 by American Society of Clinical Oncology
Chemotherapy and hormonal therapy in combination
V Hug, H Thames and J Clark
Department of Medical Oncology, M.D. Anderson Hospital and Tumor Institute, Houston, TX 77030.
The advantage of adding hormones to chemotherapy for the treatment of
patients with breast carcinoma is uncertain, and benefits and disadvantages
have been reported. An analysis of published randomized clinical trials
reveals that the growth function (differentiation- inducing function v
mitogenic function) of the hormone used may determine the ultimate benefit
of combined modality treatments.