Journal of Clinical Oncology, Vol 6, 297-302, Copyright © 1988 by American Society of Clinical Oncology
Patterns of failure in primary testicular non-Hodgkin's lymphoma
JA Martenson Jr, SJ Buskirk, DM Ilstrup, PM Banks, RG Evans, JP Colgan and JD Earle
Division of Radiation Oncology, Mayo Clinic, Rochester, MN 55905.
Patterns of failure were analyzed in 30 patients with testicular non-
Hodgkin's lymphoma: 16 had stage IE disease, ten had stage IIE, and four
had stage IV. After orchiectomy, two of the 16 patients with stage IE
disease received no additional therapy, one received multiagent
chemotherapy, and 13 received pelvic and para-aortic radiation. Twelve
patients with stage IE disease had progression, and the median time to
progression was 12 months. Of the 14 patients with extratesticular
involvement (stage IIE or IV), one (stage IV) received no treatment after
orchiectomy, three (stage IIE) received para-aortic and pelvic radiation,
and ten (seven stage IIE and three stage IV) received multiagent
chemotherapy with or without radiation. Eight of the patients with stage
IIE or IV disease had progression, and the median time to progression was
11 months. Widespread extranodal progression was observed in 17 of the 20
patients who had progression. The tendency of testicular lymphoma for early
systemic progression suggests a need for multiagent chemotherapy in initial
management.
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