Journal of Clinical Oncology, Vol 6, 380-391, Copyright © 1988 by American Society of Clinical Oncology
Photodynamic therapy
MJ Manyak, A Russo, PD Smith and E Glatstein
National Cancer Institute, Radiation Oncology Branch, Bethesda, MD 20892.
Photodynamic therapy (PDT) is an experimental cancer treatment modality
that selectively destroys cancer cells by an interaction between absorbed
light and a retained photosensitizing agent. This review discusses the
basic components of photodynamic activity and examines the clinical
applications of photodynamic therapy in cancer treatment. Treatment of
superficial and early-stage malignancies is encouraging. Technologic
advancement and further elucidation of the fundamental basis of
photodynamic action should permit treatment of more advanced malignancies.
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