Journal of Clinical Oncology, Vol 7, 940-942, Copyright © 1989 by American Society of Clinical Oncology
Raynaud's phenomenon in patients treated with cisplatin, vinblastine, and bleomycin for germ cell cancer: measurement of vasoconstrictor response to cold
SW Hansen and N Olsen
Department of Oncology ONB, Finsen Institute, Copenhagen, Denmark.
The prevalence of Raynaud's phenomenon (RP) was studied in patients treated
with cisplatin, vinblastine, and bleomycin. Thirty-two patients with germ
cell cancer were followed for a median of 78 months (range, 49 to 106
months). All had obtained complete remission during treatment; none had
relapsed at last follow-up examination. All blood samples, including serum
magnesium, were normal. The arterial vasoconstrictor response to cold in
the finger was measured by cuff- and strain-gauge techniques at 30, 15, and
10 degrees C. Blood pressure (BP) was measured auscultatorily, using a
12-cm broad cuff on the ipsilateral upper arm. Fourteen patients (44%) had
developed anamnestic RP, and all showed an exaggerated response to cold;
arterial closure was provoked in nine patients. Eighteen patients (56%)
were without finger symptoms. These patients had an exaggerated response to
cold in comparison with controls, and in two patients, RP was provoked.
None of the patients had an increased systolic pressure gradient from arm
to finger when compared with a control group. Thus, an exaggerated cold
response was found to be a prolonged vasospastic side effect not only in
patients with RP, but also in patients without finger symptoms.
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