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In Reply:

Department of Medicine I, Charite–Campus Benjamin Franklin, Berlin, Germany

We welcome the suggestion by Koch et al to consider site of origin and presence of enteropathy as candidate prognostic factors for intestinal lymphomas, though our study¹ did not show different survival in enteropathy-associated T-cell lymphoma (EATL) patients versus non-EATL patients, and could not confirm the differences in age, sex, histologic subtypes, and survival depending on lymphoma localization observed by Koch et al.² Statistically significant differences (as well as their absence) and even more observed trends in our studies comprising 94 and 56 patients with intestinal lymphoma should be interpreted with caution. Furthermore, several candidate prognostic factors like histologic subtype, lymphoma localization, and stage at presentation seem to be correlated. Establishing reliable prognostic factors for rare diseases like intestinal lymphoma clearly requires multivariate analysis of well-defined patient populations that are significantly larger than those reported in our recent studies. In the meantime, studies should certainly report and analyze as much detail as possible.

Authors' Disclosures of Potential Conflicts of Interest

The authors indicated no potential conflicts of interest.

REFERENCES

1. Daum S, Ullrich R, Heise W, et al: Intestinal non-Hodgkin's lymphoma: A multicenter prospective clinical study from the German study group on intestinal non-Hodgkin's lymphoma. J Clin Oncol 21:2740-2746, 2003[Abstract/Free Full Text]

2. Koch P, Valle FD, Berdel W, et al: Primary gastrointestinal Non-Hodgkin's lymphoma, I: Anatomical and histological distribution, clinical features, and survival data of 371 patients registered in the German Multicenter study (GIT NHL 01/92). J Clin Oncol 19:3861-3873, 2001[Abstract/Free Full Text]

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