Web Table 1. Chemotherapy: Drugs Administered to 1,167 of 1,814 Female Children Treated for a First Cancer in Childhood
| Drugs |
No. of Patients |
Median dose, moles/m2 |
Minimum to Maximum |
|
| Electrophilic agents |
783 |
17.1 |
3.2 x 10–2-668.6 |
| Cyclophosphamide |
593 |
16.1 |
3.2 x 10–2-179.7 |
| Procarbazine |
129 |
18.8 |
0.4-149.4 |
| Cisplatinum |
121 |
1.0 |
7.8 x 10–2-30.0 |
| Lomustine |
88 |
1.7 |
0.2-6.7 |
| Bleomycin |
86 |
6.3 x 10–2 |
8.1 x 10–3-0.3 |
| Caryolysine |
73 |
0.2 |
1.3 x 10–2-1.5 |
| Ifosfamide |
47 |
81.3 |
2.1 x 10–2-661.3 |
| Dacarbazine |
37 |
12.0 |
3.4-81.4 |
| Chlorambucil |
30 |
1.6 |
0.5-6.0 |
| Melphalan |
30 |
0.5 |
0.2-5.9 |
| Other drugs |
19 |
3.0 |
0.04-9.2 |
| Spindle inhibitors |
962 |
1.6 x 10–2 |
7.0 x 10–4-0.8 |
| Vincristine |
914 |
1.4 x 10–2 |
7.0 x 10–4-0.5 |
| Vinblastine |
75 |
7.1 x 10–2 |
6.1 x 10–3-0.8 |
| Topoisomerase II inhibitors |
848 |
0.19 |
2.9 x 10–4-18.9 |
| Actinomycin |
579 |
4.0 x 10–3 |
2.8 x 10–4-7.8 x 10–2 |
| Adriamycin |
452 |
0.4 |
9.1 x 10–3-2.5 |
| Teniposide |
60 |
0.7 |
2.9 x 10–2-4.2 |
| Etoposide |
35 |
2.3 |
4.9 x 10–2-18.2 |
| Nucleotide synthesis inhibitors |
199 |
13.7 |
3.9 x 10–2-1,452.9 |
| Methotrexate |
181 |
1.5 |
2.5 x 10–2-544.6 |
| Cytarabine |
92 |
7.7 |
0.2-900.0 |
| Other categories |
63 |
3.0 |
0.1-13.9 |
|
|
