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Docetaxel Plus Cyclophosphamide in Adjuvant Breast Cancer

Jewish General Hospital, Montreal, Quebec, Canada

To the Editor:

The recently described phase III trial comparing doxorubicin plus cyclophosphamide with docetaxel plus cyclophosphamide as adjuvant therapy for operable breast cancer is a very informative trial that identifies docetaxel plus cyclophosphamide (TC) as superior to doxorubicin plus cyclophosphamide (AC) for disease-free survival.¹ The results of this trial suggest that TC is preferable to AC especially in patients who have cardiac dysfunction. In addition, it may well be that TC is preferable in all high risk patients in these categories. What is the effect of HER-2 status on your results? In particular, it would be very helpful to identify the large subgroup of patients which are HER-2 negative and estrogen receptor–and/or progesterone receptor–positive. This group represents the majority of patients and it would be informative to know whether or not the TC combination is also superior in that group B.

AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST

The author(s) indicated no potential conflicts of interest.

REFERENCE

1. Jones SE, Savin MA, Holmes FA, et al: Phase III trial comparing doxorubicin plus cyclophosphamide with docetaxel plus cyclophosphamide as adjuvant therapy for operable breast cancer. J Clin Oncol 24:5381-5387, 2006[Abstract/Free Full Text]

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This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Save to my personal folders Download to citation manager Rights & Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ferrario, C. Articles by Panasci, L. C. Search for Related Content PubMed PubMed Citation Articles by Ferrario, C. Articles by Panasci, L. C. Social Bookmarking                            What's this?