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Recommended Organ Preservation Strategy for T2 Unfavorable Glottis Cancer

Amrita Institute of Medical Sciences, Kochi, India

To the Editor:

The "American Society of Clinical Oncology Clinical Practice Guideline for the Use of Larynx-Preservation Strategies in the Treatment of Laryngeal Cancer" by Pfister et al¹ is very useful in the management of laryngeal cancer. I would like to put forward the following query.

The recommended organ preservation strategy in Table 1 of the article for unfavorable T2 cancer of glottis (a deeply invasive tumor on radiographic imaging, with or without subglottic extension, with impaired mobility, indicating deeper invasion) is open organ preservation surgery or concurrent chemoradiotherapy (in selected patients with node-positive disease).

Kindly clarify the recommended strategy for T2 cancer of the glottis, unfavorable, without node positivity. Why is radiation therapy not recommended in this situation and put under other options onlyin the Table? Is concurrent chemoradiation recommended in this situation also?

AUTHOR'S DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST

The author indicated no potential conflicts of interest.

REFERENCES

1. Pfister DG, Laurie SA, Weinstein GS, et al: American Society of Clinical Oncology clinical practice guideline for the use of larynx- preservation strategies in the treatment of laryngeal cancer. J Clin Oncol 24:3693-3704, 2006[Abstract/Free Full Text]

Related Reply

• In Reply
  David G. Pfister, Scott A. Laurie, Gregory S. Weinstein, Kie-Kian Ang, Louis B. Harrison, and Gregory T. Wolf
  JCO 2007 25: 736 [Full Text]

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• American Society of Clinical Oncology Clinical Practice Guideline for the Use of Larynx-Preservation Strategies in the Treatment of Laryngeal Cancer
  David G. Pfister, Scott A. Laurie, Gregory S. Weinstein, William M. Mendenhall, David J. Adelstein, K. Kian Ang, Gary L. Clayman, Susan G. Fisher, Arlene A. Forastiere, Louis B. Harrison, Jean-Louis Lefebvre, Nancy Leupold, Marcy A. List, Bernard O. O'Malley, Snehal Patel, Marshall R. Posner, Michael A. Schwartz, and Gregory T. Wolf
  JCO 2006 24: 3693-3704 [Abstract] [Full Text]

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